| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We examined the polyphenolic constituents in chestnut needles and isolated fourteen phenolics including hydrolyzable tannins and ellagic acid derivative. Also, ellagic acid 3-C-glucoside which was derived from hydrolyzable tannins and was not yet isolated from natural resources was obtained. All the isolates showed potent antioxidative activities evaluated by ORAC test and SOD-like activity. Hydrolyzable tannins also exert tyrosinase inhibitory effect meanwhile ellagic acids which are known to have skin-whitening ability showed no activity. Additionally, ellagic acid 3-C-glucoside showed potent inhibitory effect against melanogenesis of melanoma B16 cells than the positive control of arbutin with low cytotoxicity.
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