| Project/Area Number |
22790190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YASHIRO Takashi 自治医科大学, 医学部, 教授 (80119859)
KIKUCHI Motoshi 自治医科大学, 医学部, 教授 (60332988)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体前葉 / 濾胞星状細胞 / 細胞外マトリックス / ギャップ結合 / living観察 / マトリクライン |
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| Research Abstract |
The anterior pituitary gland is composed of five types of hormone-producing cells and folliculo-stellate cells(FS cells), which do not produce classical anterior pituitary hormones. These cell aggregations form cell cords or clusters surrounded by different types of extracellular matrices(ECM), which provide the mechanical integrity, rigidity, and elasticity. The present study revealed that FS cells, under the influence of ECM, may play important functional roles as follows:
1) FS cells facilitate the gap junctional cell-to-cell communication. 2) The proliferation of FS cells is induced by a caveolin 3-mediated integrinβ1 signaling pathway, leading to activation of the MAPK pathway. 3) ECM promotes MMP-9 expression in FS cells and that MMP-9 is required for the interconnection and proliferation of FS cells. 4) FS cells secreted CXCL12, and that the CXCL12/CXCR4 axis between FS cells plays a central role in the mechanism of FS cell network formation.
It is hoped that these findings contribute to elucidating the cell function in the anterior pituitary gland, the neoplasia mechanism and tumor therapy.
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