Investigation of the mechanism of TRP channel mediated by a lipid mediator, 2ccPA, via LPA receptor
Project/Area Number |
22790203
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | Ochanomizu University |
Principal Investigator |
GOTOH Mari お茶の水女子大学, サイエンス&エデュケーションセンター, 研究協力員 (80467050)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 環状ホスファチジン酸 / 生理活性脂質 / LPA受容体 |
Research Abstract |
We have been indicated that cyclic phosphatidic acid, cPA, and its derivative, 2ccPA, are potent inhibitors of nociceptive transmission by C-primary afferents, and reverse inflammatory and neuropathic pain. In this research, we aimed to clarify the molecular mechanism of analgesic function of cPA and 2ccPA. We found that the activation of LPA5 receptor by 2ccPA does not affect the activation of TRPV1. Therefore, we are going to examine the effect of 2ccPA on the other TRP channel activation.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis2012
Author(s)
Mari GOTOH, Yuko FUJIWARA, Junming YUE, Jianxiong LIU, SueChin LEE, James FELLS, Ayako UCHIYAMA, Kimiko MURAKAMI-MUROFUSHI, Stephen KENNEL, Jonathan WALL, Renukadevi PATIL, Renuka GUPTE, Louisa BALAZS, Duane D. MILLER, Gabor J. TIGYI
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Journal Title
Biochem. Soc. Trans
Volume: 40, (1)
Issue: 1
Pages: 31-36
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid2010
Author(s)
Renuka GUPTE, Anjaih SIDDAM, Yan LU, Wei LI, Yuko FUJIWARA, Nattapon PANUPINTHU, Truc-Chi PHAM, Daniel L. BAKER, Abby L. PARRILL, Mari GOTOH, Kimiko MURAKAMI-MUROFUSHI, Susumu KOBAYASHI, Gordon B. MILLS, Gabor TIGYI, Duane D. MILLER
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume: 20
Issue: 24
Pages: 7525-7528
DOI
Related Report
Peer Reviewed
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[Journal Article] (S)-FTY720-Vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine1-phosphate GPCR signaling and inhibits autotaxin activity2010
Author(s)
William J. VALENTINE, Gyongyi N. KISS, Jianxiong LIU, Shuyu E, Mari GOTOH, Kimiko MURAKAMI-MUROFUSHI, Truc-Chi PHAM, Daniel L. BAKER, Abby L. PARRILL, Xuequan LU, Chaode SUN, Robert BITTMAN, Nigel PYNE, Gabor TIGYI
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Journal Title
Cellular Signaling
Volume: 22
Issue: 10
Pages: 1543-1553
DOI
Related Report
Peer Reviewed
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[Journal Article] (S)-FTY720-Vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity2010
Author(s)
William J.VALENTINE, Gyongyi N.KISS, Jianxiong LIU, Shuyu E, Mari GOTOH, Kimiko MURAKAMI-MUROFUSHI, Truc-Chi PHAM, Daniel L.BAKER, Abby L.PARRILL, Xuequan LU, Chaode SUN, Robert BITTMAN, Nigel PYNE, Gabor TIGYI
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Journal Title
Cellular Signaling
Volume: 22
Pages: 1543-1553
Related Report
Peer Reviewed
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[Presentation] The role of autotaxin and stroma LPA receptors in cancer invasion and metastasis2011
Author(s)
Yuko FUJIWARA, Sue Chin LEE, Jianxiong LIU, Mari GOTOH, Ayako UCHIYAMA, Junming YUE, Renuka GUPTE, Stephen KENNEL, Jonathan WALL, Kimiko MURAKAMI-MUROFUSHI, Duane D. MILLER, Gabor TIGYI
Organizer
Lysophospholipid mediators in health and disease
Place of Presentation
Il Ciocco, Barga, Lucca (Italy)
Related Report
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[Presentation] Synthesis and Biological Activity of thia-cPA2010
Author(s)
Ryo TANAKA, Masaru KATO, Mari GOTOH, Emi NOZAKI, Shuwa HANAZAWA, Atsuo NAKAZAKI, Takahiro SUZUKI, Kimiko MUROFUSHI, Susumu KOBAYASHI
Organizer
The 59th Symposium on Kanto branch of the Society of Synthetic Organic Chemistry
Place of Presentation
Tokyo
Year and Date
2010-05-22
Related Report
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[Presentation] Synthesis and Biological Activity of thia-cPA2010
Author(s)
Ryo TANAKA, Masaru KATO, Mari GOTOH, Emi NOZAKI, Shuwa HANAZAWA, Atsuo NAKAZAKI, Takahiro SUZUKI, Kimiko MUROFUSHI, Susumu KOBAYASHI
Organizer
The 130th Annual Meeting of thePharmaceutical Society of Japan
Place of Presentation
Okayama
Year and Date
2010-03-28
Related Report
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