| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have been indicated that cyclic phosphatidic acid, cPA, and its derivative, 2ccPA, are potent inhibitors of nociceptive transmission by C-primary afferents, and reverse inflammatory and neuropathic pain. In this research, we aimed to clarify the molecular mechanism of analgesic function of cPA and 2ccPA. We found that the activation of LPA5 receptor by 2ccPA does not affect the activation of TRPV1. Therefore, we are going to examine the effect of 2ccPA on the other TRP channel activation.
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