Antipsychotic potential of antioxidative agents in animal model for schizophrenia

• Project/Area Number: 22790245
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Niigata University
• Principal Investigator: MIZUNO Makoto 新潟大学, 脳研究所, 特任准教授 (20345515)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 栄養因子 / 活性酸素 / ドパミン / 認知 / 統合失調症 / 活性酵素

Research Abstract

We established the model for schizophrenia and examined the antipsychotic actions of antioxidants. Administration of antioxidants for a week significantly ameliorated deficits of social interaction and prepulse inhibition of the schizophrenia model rats. These results suggest that antioxidants may be a new class of antipsychotic drugs for schizophrenia.

Research Products

• [Journal Article] Nawa H Pallidal Hyperdopaminergic Innervation Underlying D2 Receptor-Dependent Behavioral Deficits in the Schizophrenia Animal Model Established by EGF (2011)
  • Author(s): Sotoyama H, Zheng Y, Iwakura Y, Mizuno M, Aizawa M, Shcherbakova K, Wang R, Namba H
  • Journal Title: PLoS One Volume: 6 Pages: 25831-25831
  • Peer Reviewed
• [Journal Article] The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats (2010)
  • Author(s): Mizuno M, Kawamura H, Ishizuka Y, Sotoyama H, Nawa H
  • Journal Title: Pharmacol Biochem Behav Volume: 97 Pages: 392-398
  • Peer Reviewed
• [Journal Article] Antipsychotic potentical of quinazoline ErbB1 inhibitors in a schizophrenia model established with neonatal hippocampal lesioning (2010)
  • Author(s): Mizuno M, Shibuya M, Zheng Y, Sotoyama H, Eda Y, Iwakura Y, Kato T, Takasu K, Nawa H
  • Journal Title: J Pharmacol Sci Volume: 114 Pages: 320-331
  • Peer Reviewed
• [Journal Article] Activation of mammalian target of rapamycin signaling in spatial learning (2010)
  • Author(s): Qi S, Mizuno M, Yonezawa K, Nawa H, Takei N
  • Journal Title: Neurosci Res Volume: 68 Pages: 88-93
  • Peer Reviewed
• [Presentation] Antipsychotic potential of thalidomide and lenalidomide in immune/inflammatory models for schizophrenia (2011)
  • Author(s): 水野誠、鄭英君、那波宏之
  • Organizer: Advancing Drug Discovery for Schizophrenia
  • Place of Presentation: アメリカ合衆国・ニューヨーク
  • Year and Date: 2011-03-09
• [Presentation] Antipsychotic potential of thalidomide and lenalidomide in immune/inflammatory models for schizophrenia (2011)
  • Author(s): 水野誠
  • Organizer: Advancing Drug Discovery for Schizophrenia
  • Place of Presentation: ニューヨーク、アメリカ合衆国
• [Presentation] Effects of antioxidative agents on behavioral impairments in schizophrenia models (2010)
  • Author(s): 水野誠、森田影介、那波宏之
  • Organizer: 第40回北米神経科学会
  • Place of Presentation: サンディエゴ、アメリカ合衆国