Antipsychotic potential of antioxidative agents in animal model for schizophrenia
| Project/Area Number |
22790245
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
MIZUNO Makoto 新潟大学, 脳研究所, 特任准教授 (20345515)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 栄養因子 / 活性酸素 / ドパミン / 認知 / 統合失調症 / 活性酵素 |
|---|
| Research Abstract |
We established the model for schizophrenia and examined the antipsychotic actions of antioxidants. Administration of antioxidants for a week significantly ameliorated deficits of social interaction and prepulse inhibition of the schizophrenia model rats. These results suggest that antioxidants may be a new class of antipsychotic drugs for schizophrenia.
|
Report
(3 results)
Research Products
(7 results)
