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Antipsychotic potential of antioxidative agents in animal model for schizophrenia

Research Project

Project/Area Number 22790245
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionNiigata University

Principal Investigator

MIZUNO Makoto  新潟大学, 脳研究所, 特任准教授 (20345515)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords栄養因子 / 活性酸素 / ドパミン / 認知 / 統合失調症 / 活性酵素
Research Abstract

We established the model for schizophrenia and examined the antipsychotic actions of antioxidants. Administration of antioxidants for a week significantly ameliorated deficits of social interaction and prepulse inhibition of the schizophrenia model rats. These results suggest that antioxidants may be a new class of antipsychotic drugs for schizophrenia.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] Nawa H Pallidal Hyperdopaminergic Innervation Underlying D2 Receptor-Dependent Behavioral Deficits in the Schizophrenia Animal Model Established by EGF2011

    • Author(s)
      Sotoyama H, Zheng Y, Iwakura Y, Mizuno M, Aizawa M, Shcherbakova K, Wang R, Namba H
    • Journal Title

      PLoS One

      Volume: 6 Pages: 25831-25831

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats2010

    • Author(s)
      Mizuno M, Kawamura H, Ishizuka Y, Sotoyama H, Nawa H
    • Journal Title

      Pharmacol Biochem Behav

      Volume: 97 Pages: 392-398

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antipsychotic potentical of quinazoline ErbB1 inhibitors in a schizophrenia model established with neonatal hippocampal lesioning2010

    • Author(s)
      Mizuno M, Shibuya M, Zheng Y, Sotoyama H, Eda Y, Iwakura Y, Kato T, Takasu K, Nawa H
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 320-331

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of mammalian target of rapamycin signaling in spatial learning2010

    • Author(s)
      Qi S, Mizuno M, Yonezawa K, Nawa H, Takei N
    • Journal Title

      Neurosci Res

      Volume: 68 Pages: 88-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Antipsychotic potential of thalidomide and lenalidomide in immune/inflammatory models for schizophrenia2011

    • Author(s)
      水野誠、鄭英君、那波宏之
    • Organizer
      Advancing Drug Discovery for Schizophrenia
    • Place of Presentation
      アメリカ合衆国・ニューヨーク
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Antipsychotic potential of thalidomide and lenalidomide in immune/inflammatory models for schizophrenia2011

    • Author(s)
      水野誠
    • Organizer
      Advancing Drug Discovery for Schizophrenia
    • Place of Presentation
      ニューヨーク、アメリカ合衆国
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of antioxidative agents on behavioral impairments in schizophrenia models2010

    • Author(s)
      水野誠、森田影介、那波宏之
    • Organizer
      第40回北米神経科学会
    • Place of Presentation
      サンディエゴ、アメリカ合衆国
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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