Research Project
Grant-in-Aid for Young Scientists (B)
Chronic stress causes emotional changes, such as depression and anxiety. However, the underlying mechanism remains unknown. We have employed repeated social defeat stress, a mouse model of major depression, and have shown that prostaglandin(PG) E2 and its receptor EP1 mediate emotional changes by chronic stress through attenuation of prefrontal dopaminergic activity. Further, cyclooxygenase(COX) 1, a PG synthase expressed in microglia in the brain, is critical for emotional changes by repeated social defeat, suggesting a potential role of PGE2 synthesis in microglia.
All 2012 2011 2010
All Journal Article (19 results) (of which Peer Reviewed: 15 results) Presentation (40 results) Book (4 results)
Neuropharmacology
Volume: 62 Pages: 1841-1847
Nat. Neurosci.
Volume: 15 Pages: 373-380
J. Neurosci
Volume: 32 Pages: 4319-4329
日本薬理学雑誌
Volume: 139巻 Pages: 152-156
Volume: 62 Issue: 4 Pages: 1841-1847
10.1016/j.neuropharm.2011.12.007
120003874264
Nature Neuroscience
Volume: 15 Issue: 3 Pages: 373-380
10.1038/nn.3020
120003726113
J.Neurosci.
Volume: 32 Issue: 12 Pages: 4319-4329
10.1523/jneurosci.5952-11.2012
Volume: 139 Pages: 152-156
Br. J. Pharmacol
Volume: 163 Pages: 1237-1249
FASEB J.
Volume: 25 Pages: 813-818
Nat. Rev. Endocrinol.
Volume: 7 Pages: 163-175
120004185034
FEBS Lett.
Volume: 585 Pages: 2357-2362
Eur. J. Neurosci.
Volume: 34 Pages: 594-604
PLoS One
Volume: 6 Issue: 9 Pages: e25465-e25465
10.1371/journal.pone.0025465
Volume: 585 Issue: 14 Pages: 2357-2362
10.1016/j.febslet.2011.06.004
European Journal of Neuroscience
Volume: 34 Issue: 4 Pages: 594-604
10.1111/j.1460-9568.2011.07774.x
British Journal of Pharmacology
FASEB Journal
Nature Reviews Endocrinology