| Project/Area Number |
22790279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
WATANABE Takashi 名古屋大学, 大学院・医学系研究科, 特任講師 (10402562)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞極性 / 細胞遊走 / 細胞内シグナル伝達 / Rhoファミリー / 細胞骨格 / シグナル伝達 |
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| Research Abstract |
Major aims in this research are to reveal the molecular mechanisms governing a front-rear polarity in motile cells. Migrating cells acquire front-rear polarity along the directional axis, with signaling molecules, adhesions and the cytoskeleton distributed asymmetrically. At the front of migrating cells, they maintain the higher activity of small GTPase Rac and persistently form adhesion sites toward substratum. Activated Rac at the front then controls microtubule dynamics. This research demonstrates that Tiam1 accumulates at adhesion sites and is responsible for Rac activation at the front of motile. Furthermore, this research also shows the molecular mechanisms controlling microtubule dynamics downstream of Rac in a region-specific manner.
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