Analysis for physiological role of the Ca2+-binding ER protein calumin

• Project/Area Number: 22790288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: YAMAMOTO Shinichiro 京都大学, 大学院・薬学研究科, 助教 (10542102)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 小胞体 / Ca^<2+> / 脂質輸送 / 極性細胞

Research Abstract

Calumin is transmembrane protein on endoplasmic reticulum. Although calumin knockout in mice is embryonic lethal around E10. 5-11. 5, the physiological role is no clear. Thus, we investigated the physiological role of calumin. Calumin is specifically expressed in yolk sac endoderm cells which are the principal nutrient-transporting cells. Additionally, lipid droplets are accumulated in calumin knockout yolk sac endoderm cells. Therefore, it was suggested that calumin was involved in lipid transport in endoderm cells.

Research Products

• [Journal Article] The juvenile myoclonicepilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death (2011)
  • Author(s): Katano M, Aguan K, Hara Y, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K & Mori Y
  • Journal Title: Cell Calcium Volume: (in press) Issue: 2 Pages: 179-185
  • DOI: 10.1016/j.ceca.2011.12.011
  • Peer Reviewed
• [Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance (2011)
  • Author(s): Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
  • Journal Title: Cell Metab Volume: 14 Issue: 2 Pages: 231-241
  • DOI: 10.1016/j.cmet.2011.05.011
  • NAID: 120003255678
  • URL: http://hdl.handle.net/2433/143634
  • Peer Reviewed
• [Journal Article] TRPA1 underlies a sensing mechanism for O_2 (2011)
  • Author(s): Takahashi N, Kuwaki K, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J & Mori Y
  • Journal Title: Nature Chem. Biol. Volume: 7 Issue: 10 Pages: 701-711
  • DOI: 10.1038/nchembio.640
  • Peer Reviewed
• [Journal Article] Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels (2010)
  • Author(s): Yamamoto S, Takahashi N, Mori Y
  • Journal Title: Progress in Biophysics and Molecular Biology Volume: 103 Pages: 18-27
  • Peer Reviewed