Ror1-mediated signaling and its role in development and cancer
| Project/Area Number |
22790291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
NISHITA Michiru 神戸大学, 大学院・医学研究科, 准教授 (30379359)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Ror受容体チロシンキナーゼ / Wnt / がん / トリプルネガティブ乳癌 / Ror1 / Wnt5a / Ror / 受容体型チロシンキナーゼ |
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| Research Abstract |
Mouse embryonic fibroblasts isolated from Ror1 ; Ror2 double knockout mice and human Burkitt's lymphoma cells were used to study their responses to Wnt5a. We found that inhibition of Wnt/.-catenin signaling by Wnt5a is mediated not only by Ror2 but also by Ror1. We also found that Ror1 is overexpressed in human triple-negative breast cancer cells and thereby activates signaling molecules, such as c-Src, Akt, Erk and Stat3, and cell proliferation.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., and Takahashi, N.
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Journal Title
Nat. Med
Volume: 18
Pages: 405-412
Related Report
Peer Reviewed
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[Journal Article] Dissection of Wnt5a-Ror2 Signaling Leading to Matrix Metalloproteinase(MMP-13) Expression2012
Author(s)
Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., and Minami, Y.
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 1588-1599
Related Report
Peer Reviewed
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization2010
Author(s)
Nishita, M., Itsukushima, S., Nomachi, A., Endo, M., Wang, Z., Inaba, D., Qiao, S., Takada, S., Kikuchi, A., and* Minami, Y.
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Journal Title
Mol. Cell. Biol
Volume: 30
Pages: 3610-3619
Related Report
Peer Reviewed
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