| Project/Area Number |
22790309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INOUE Jun 東京医科歯科大学, 難治疾患研究所, 助教 (50568326)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経芽腫 / 自然退縮 / 細胞死 / タンパク質分解 / ユビキチン / 腫瘍退縮 |
|---|
| Research Abstract |
It is unknown for the molecular mechanism of spontaneous regression of neuroblastoma(NB). I have previously demonstrated that the cell death mediated by accumulation of LAPTM5(lysosomeal-associated protein multispanning membrane 5) protein was closely associated with tumor regression of NBs. With the support of this grant, I clarified the mechanism of transcriptional and post-translational regulation for the expression, and suggested that the dysregulation of its mechanism may LAPTM5-mediated cell death in NB cells.
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