Molecular mechanism of the spontaneous regression of neuroblastoma

• Project/Area Number: 22790309
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INOUE Jun 東京医科歯科大学, 難治疾患研究所, 助教 (50568326)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 神経芽腫 / 自然退縮 / 細胞死 / タンパク質分解 / ユビキチン / 腫瘍退縮

Research Abstract

It is unknown for the molecular mechanism of spontaneous regression of neuroblastoma(NB). I have previously demonstrated that the cell death mediated by accumulation of LAPTM5(lysosomeal-associated protein multispanning membrane 5) protein was closely associated with tumor regression of NBs. With the support of this grant, I clarified the mechanism of transcriptional and post-translational regulation for the expression, and suggested that the dysregulation of its mechanism may LAPTM5-mediated cell death in NB cells.

Research Products

• [Journal Article] A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers (2012)
  • Author(s): Bai H, Inazawa J, et al
  • Journal Title: Oncogene Volume: (Epub ahead of print) Issue: 40 Pages: 4397-408
  • DOI: 10.1038/onc.2011.613
  • Peer Reviewed
• [Journal Article] The HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5(LAPTM5) and prevents LAPTM5-mediated cell death (2011)
  • Author(s): Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J
  • Journal Title: J Biol Chem Volume: 286 Pages: 44086-44094
  • Peer Reviewed
• [Journal Article] HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death (2011)
  • Author(s): Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Pages: 44086-44094
  • Peer Reviewed
• [Presentation] 食道癌におけるオートファジーATG7の不活性化 (2011)
  • Author(s): 小西博貴、井上純、市野瀬志津子、津田均、河野辰幸、市川大輔、大辻英吾、井本逸勢、稲澤讓治
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場.愛知
  • Year and Date: 2011-10-04
• [Presentation] 癌におけるオートファジー関連遺伝子LC3Avariant-1の不活性化 (2011)
  • Author(s): 井上純、白樺、河野辰幸、稲澤讓治
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場.愛知
  • Year and Date: 2011-10-04
• [Presentation] 癌におけるオートファジー関連遺伝子LC3 Avariant-1の不活性化 (2011)
  • Author(s): 井上純、白樺、河野辰幸、稲澤讓治
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] 癌におけるオートファジー障害 (2010)
  • Author(s): 井上純
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪リーガロイヤルホテル
  • Year and Date: 2010-09-24
• [Presentation] 癌細胞におけるオートファジー経路の障害 (2010)
  • Author(s): 井上純、稲澤譲治
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: シンポジウム「癌とオートファジー」大阪国際会議場・リーガロイヤルホテル.大阪
  • Year and Date: 2010-09-23
• [Presentation] ヒト癌におけるLC3A variant-1の発現低下の意義 (2010)
  • Author(s): 白樺、井上純、井本逸勢、稲澤讓治
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル.大阪
  • Year and Date: 2010-09-22
• [Presentation] Lysosomal-associated protein multispanning transmembrane 5 gene(LAPTM5) is associated with spontaneous regression of neuroblastomas (2010)
  • Author(s): Inoue J, Misawa A, Tanaka Y, Ichinose S, Sugino Y, Hosoi H, Sugimoto T, Imoto I, Inazawa J
  • Organizer: 101th annual meeting of American Association for Cancer Research 2010
  • Place of Presentation: Washington, DC, USA
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/section/genomics/mc/index.html