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Regulation of directionality of chemotaxing leukocyte by the polarity protein complex

Research Project

Project/Area Number 22790321
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKyushu University

Principal Investigator

SACHIKO Kamakura  九州大学, 医学研究院, 助教 (80398081)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞 / 白血球 / ケモタキシス / 好中球 / 遊走方向
Research Abstract

Cell movement directed by a gradient of a diffusible chemoattractant is known aschemotaxis, which plays a vital role in immune responses. Neutrophilic leukocytes, crucial for host defense, move toward the source of chemoattractants, which are derived from invading microbes and/or produced by infected hosts, thereby arriving correctly at sites of infection to kill pathogens. Successful chemotaxis requires not only increased motility but also sustained directionality. In this study, we analyzed molecular mechanisms for the directionality control.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (3 results)

  • [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein(LGN)2011

    • Author(s)
      Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, Sumimoto H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 19210-19215

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex2011

    • Author(s)
      Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, Scott B.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 2861-2866

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein(LGN)2011

    • Author(s)
      Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, and Sumimoto H
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Issue: 48 Pages: 19210-19215

    • DOI

      10.1073/pnas.1110951108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidasecomplex2011

    • Author(s)
      Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, and Scott B
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Issue: 7 Pages: 2861-2866

    • DOI

      10.1073/pnas.1017309108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex.2011

    • Author(s)
      Takemoto, D., et al
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Pages: 2861-2866

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane phospholipid metabolism during phagocytosis in human neutrophils2010

    • Author(s)
      Minakami R, Maehara Y, Kamakura S, Kumano O, Miyano K, and Sumimoto H.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 409-423

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane phospholipid metabolism during phagocytosis in human neutrophils.2010

    • Author(s)
      Minakami, R., et al
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 409-423

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規Par6結合タンパク質による上皮細胞極性の制御機構2011

    • Author(s)
      早瀬純也,鎌倉幸子,岩切優子,山口佳洋,伊崎智子,伊藤隆司,住本英樹
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規NuMA結合タンパク質による分裂期染色体の整列調節機構2011

    • Author(s)
      岩切優子、鎌倉幸子、住本英樹
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞極性関連タンパク質InscuteableとLGNとの複合体のX線結晶構造解析2011

    • Author(s)
      湯澤聡、鎌倉幸子、岩切優子、早瀬純也、住本英樹
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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