| Project/Area Number |
22790321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞 / 白血球 / ケモタキシス / 好中球 / 遊走方向 |
|---|
| Research Abstract |
Cell movement directed by a gradient of a diffusible chemoattractant is known aschemotaxis, which plays a vital role in immune responses. Neutrophilic leukocytes, crucial for host defense, move toward the source of chemoattractants, which are derived from invading microbes and/or produced by infected hosts, thereby arriving correctly at sites of infection to kill pathogens. Successful chemotaxis requires not only increased motility but also sustained directionality. In this study, we analyzed molecular mechanisms for the directionality control.
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