| Project/Area Number |
22790323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUZUKI Kentaro 熊本大学, 発生医学研究所, 助教 (20404345)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 上皮間葉転換 / Epithelial-Mesenchymal Transition(EMT) / Wnt/b-catenin / Bmp(Bone morphogenetic protein) / 発生・分化 / 増殖因子 / 癌 / Wnt/β-catenin / Bmp / Dkk1 |
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| Research Abstract |
To understand the molecular mechanisms of the Epithelial-Mesenchymal Transition(EMT) by Wnt/・-catenin signaling pathway, we analyzed the embryonic skin of K5-Cre Catnb^<(ex3) fl/+> mice. Expression of Snail, one of the EMT induce factors, was increased in K5-Cre Catnb^<(ex3) fl/+> mice. In addition to the snail, Bone morphogenetic protein(Bmp) signaling was activated in the mutant mice. Interestingly, double compound mutant mice with BmprIA, K5-Cre Catnb^<(ex3) fl/+> BmprIA^<fl/fl> DKO mice, showed the accelerated EMT. These results suggest that Wnt/・-catenin signaling may act not only as the EMT-activator but also as the EMT-repressor through the Bmp signaling.
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