Analysis of the molecular mechanism of CD44-mediated glucose metabolism in cancer cells for the development of new cancer therapy

• Project/Area Number: 22790326
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Keio University
• Principal Investigator: NAGANO Osamu 慶應義塾大学, 医学部, 助教 (30404346)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 癌 / 遺伝子 / 細胞・組織 / 遺伝性

Research Abstract

To examine whether the CD44-mediated modulation of glucose metabolism could be a new target for cancer therapy, we investigated the effect of CD44 expression on the activity of PKM2, a key enzyme for glycolysis. PKM2 was interacted with CD44 and such interaction increased the tyrosine phosphorylation of PKM2 leading to the augmentation of the glycolytic phenotype of cancer cells. Thus, CD44-mediated modulation of glycolysis pathway was found to be a new molecular target for cancer therapy.

Research Products

• [Journal Article] Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells (2011)
  • Author(s): Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M, Saya H
  • Journal Title: Cancer Research Volume: 72 Pages: 1438-1448
  • Peer Reviewed
• [Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization (2011)
  • Author(s): 永野修
  • Organizer: 第26回日本整形外科学会
  • Place of Presentation: ベイシア文化ホール(群馬)
  • Year and Date: 2011-10-20
• [Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization (2011)
  • Author(s): 永野修
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-04
• [Presentation] CD44バリアントアイソフォームはシスチントランスポーターxCTの安定化を誘導し癌細胞の抗酸化システムを制御する (2011)
  • Author(s): 永野修
  • Organizer: 第4回SYMPHONY研究会
  • Place of Presentation: ホテルメトロポリタンエドモント(東京)
  • Year and Date: 2011-09-10
• [Presentation] CD44バリアントアイソフォームはシスチントランスポーターxCTの安定化を誘導し癌細胞の抗酸化システムを制御する (2011)
  • Author(s): 永野修
  • Organizer: 第4回SYMPHONY研究会
  • Place of Presentation: ホテルメトロポリタンエドモント(東京)(招待講演)
  • Year and Date: 2011-09-10
• [Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization (2011)
  • Author(s): 永野修
  • Organizer: 第29回骨代謝学会
  • Place of Presentation: グランキューブ大阪(大阪)
  • Year and Date: 2011-07-30
• [Presentation] Impact of CD44 Variant Form in Gastric Cancer (2011)
  • Author(s): 永野修
  • Organizer: SGCC 4th Annual Scientific Meeting
  • Place of Presentation: National University of Singapore(シンガポール)
  • Year and Date: 2011-07-06
• [Presentation] Impact of CD44 Variant Form in Gastric Cancer (2011)
  • Author(s): 永野修
  • Organizer: SGCC 4th Annual Scientific Meeting
  • Place of Presentation: National University of Singapore(シンガポール)(招待講演)
  • Year and Date: 2011-07-06
• [Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization (2011)
  • Author(s): 永野修
  • Organizer: 第15回分子標的学会
  • Place of Presentation: ホテル日航東京(東京)
  • Year and Date: 2011-06-24
• [Presentation] The role of CD44 in the expansion of gastric stem-like tumor cells (2010)
  • Author(s): 永野修
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル大阪
  • Year and Date: 2010-09-23
• [Remarks]
  • URL: http://www.genereg.jp/