Clinicopathologic and molecular analysis in mucoepidermoid carcinoma

• Project/Area Number: 22790351
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: MIYABE Satoru 名古屋市立大学, 大学院・医学研究科, 助教 (40534582)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子病理学 / 唾液腺腫瘍

Research Abstract

We studied MAML2 gene splits by FISH method using theMAML2 break-apart probe in mucoepidermoid carcinoma, for clarifying the clinicopathological features of MAML2.related gene fusion. In result, patients with MAML2 fusion gene showed clinicopathological features with good prognoses. It showed it was possible that MAML2-related gene fusion defined a group of good prognosis.

Research Products

• [Journal Article] Impact of CRTC1/3-MAML2 Fusions on Histological Classification and Prognosis of Mucoepidermoid Carcinoma. (2011)
  • Author(s): Okumura Y, Miyabe S, Nakayama Y, Fujiyoshi, Y, Hahttori H, Shimozato K, Inagaki H
  • Journal Title: Histopathology Volume: 59(1) Pages: 90-7
  • Peer Reviewed
• [Journal Article] Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma (2011)
  • Author(s): 奥村嘉英、宮部悟、稲垣宏, 他
  • Journal Title: Histopathology Volume: 59 Pages: 90-97
  • Peer Reviewed
• [Journal Article] Impact of CRTC1/3-MAML2 Fusions on Histological Classification and Prognosis of Mucoepidermoid Carcinoma (2011)
  • Author(s): Okumura Yoshihide, Miyabe Satoru, et al.(Second author)
  • Journal Title: Histopathology Volume: (in press)
  • Peer Reviewed
• [Presentation] 唾液腺腫瘍の分子病理学的解析とその臨床病理学的意義.粘表皮癌を中心に. (2012)
  • Author(s): 宮部悟、他
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 粘表皮癌におけるCRTC1-MAML2、CRTC3-MAML2キメラ遺伝子の臨床病理学的意義 (2012)
  • Author(s): 奥村嘉英, 宮部悟、他
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 唾液腺原発粘表皮癌におけるCRTC3-MAML2キメラ遺伝子の臨床病理学的意義 (2012)
  • Author(s): 中山崇久, 宮部悟, 他
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] CRTC1/3-MAML2キメラ遺伝子が粘表皮癌の病理学的分類や予後に与える影響 (2011)
  • Author(s): 奥村嘉英、宮部悟、稲垣宏, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-30
• [Presentation] 非定型ワルチン腫瘍におけるCRTC1/3-MAML2キメラ遺伝子の検討 (2011)
  • Author(s): 中山崇久、宮部悟、稲垣宏, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-30
• [Presentation] 唾液腺原発粘表皮癌におけるFISH法を用いた新たなキメラ遺伝子の検討 (2011)
  • Author(s): 野田晴菜、宮部悟、稲垣宏, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-30
• [Presentation] 唾液腺粘表皮癌におけるメチル化解析 (2011)
  • Author(s): 宮部悟、稲垣宏, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-04-29
• [Presentation] 唾液腺粘表皮癌におけるCRTC1-,CRTC3-MAML2キメラ遺伝子の臨床病理学的意義 (2011)
  • Author(s): 宮部悟, 他
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 熊本市民会館(熊本)
  • Year and Date: 2011-01-28
• [Presentation] 唾液腺原発粘表皮癌におけるキメラ遺伝子の臨床病理学的検討 (2010)
  • Author(s): 中山崇久、宮部悟, 他
  • Organizer: 日本口腔外科
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2010-10-21
• [Presentation] 唾液腺原発粘表皮癌におけるCRTC1/3-MAML2キメラ遺伝子の臨床病理学的意義および予後解析 (2010)
  • Author(s): 奥村嘉英、宮部悟, 他
  • Organizer: 日本病理学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-04-28