Role of podocalyxin and EMT in undifferentiated thyroid carcinoma.

• Project/Area Number: 22790352
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Wakayama Medical University
• Principal Investigator: KODAMA Rieko 和歌山県立医科大学, 医学部, 学内助教 (20336887)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 癌 / 病理学

Research Abstract

Podocalyxin overexpression in ONCO-DG-1 and B-CPAP papillary thyroid carcinoma cells results in an estimated 4-fold increase in filopodia formation, phosphorylation of ezrin, and an approximately 2-fold increase in cancer cell migration.