The relationship between fascin-overexpression and RAS signaling pathway in pancreatic cancer

• Project/Area Number: 22790353
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Saitama Medical University
• Principal Investigator: YAMAGUCHI Hiroshi 埼玉医科大学, 医学部, 助教 (20510697)
• Co-Investigator(Renkei-kenkyūsha): FURUKAWA Toru 東京女子医科大学, 医学部, 教授 (30282122)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: fascin / 膵癌 / RAS信号伝達経路 / RASシグナル伝達経路 / 体細胞変異

Research Abstract

Inhibition of RAS signaling pathway induced the fascin down-regulation in the pancreatic cancer cell-lines which normally showed fascin-overexpression. The similar results were revealed in promoter activity assay. These results indicate that fascin-overexpression in the pancreatic cancer is caused by an activated RAS signaling pathway.

Research Products

• [Journal Article] Molecular characteristics and biological behaviours of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms. (2011)
  • Author(s): Xiao HD, Yamaguchi H(double author), Dias-Santagata D, Kuboki Y, Akhavanfard S, Hatori T, Yamamoto M, Shiratori K, Kobayashi M, Shimizu M, Fernandez-Del Castillo C, Mino-Kenudson M, Furukawa T
  • Journal Title: J Pathol Volume: 224(4) Issue: 4 Pages: 508-16
  • DOI: 10.1002/path.2875
  • Peer Reviewed
• [Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas (2011)
  • Author(s): Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, Shin N, Ishida K, Morikawa T, MotoiF, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Harada Y, Furukawa
  • Journal Title: Am J Surg Pathol Volume: 35(12) Issue: 12 Pages: 1812-7
  • DOI: 10.1097/pas.0b013e31822769a0
  • Peer Reviewed
• [Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas (2011)
  • Author(s): Furukawa, T., et al
  • Journal Title: Gut Volume: 60 Issue: 4 Pages: 509-516
  • DOI: 10.1136/gut.2010.210567
  • Peer Reviewed
• [Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas (2011)
  • Author(s): Furukawa T
  • Journal Title: Gut Volume: 60 Pages: 509-516
  • Peer Reviewed
• [Journal Article] Molecular characteristics and biological behaviors of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms
  • Author(s): Yamaguchi H (double first author)
  • Journal Title: J Pathol Volume: (In press)
  • Peer Reviewed
• [Presentation] Somatic Mutations in PIK3CA and Activation of Akt in Intraductal Tubulopapillary Neoplasms of the Pancreas (2011)
  • Author(s): Yamaguchi H
  • Organizer: Joint meeting of the 4th Asian-Oceanic Pancreas Association and 2011 Annual Congress of the Korean Pancreatobiliary Association
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-09-03
• [Presentation] 膵管内管状乳頭腫瘍/Intraductal tubulopapillary neoplasmにおけるPIK3CAの体細胞変異 (2011)
  • Author(s): 山口浩, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-28
• [Presentation] 膵管内管状乳頭腫瘍/Intraductal tubulopapillary neoplasmにおけるPIK3CAの体細胞変異 (2011)
  • Author(s): 山口浩
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2011-04-28
• [Presentation] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas (2011)
  • Author(s): Yamaguchi H, Furukawa T, Kuboki Y, Hatori T, Higashi M, Morikawa T, Kanno A, Orikasa H, Harada Y, Shimizu M
  • Organizer: 4th AOPA & KPBA Joint Meeting of the 4th Asian-Oceanic Pancreas Association and 2011 annual Congress of the Korean Pancreatobiliary Association
  • Place of Presentation: Jeju, Korea
• [Presentation] 膵癌取扱い規約をめぐって-膵管内腫瘍の新しい分類システムの提唱- (2010)
  • Author(s): 山口浩
  • Organizer: 日本消化器関連学会週間
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-10-15
• [Presentation] A new classification system for primary intraductal neoplasms of the pancreas (2010)
  • Author(s): Yamaguchi H
  • Organizer: 第14回国際膵臓学会&第41回日本膵臓学会大会(合同学会)
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-07-11
• [Presentation] パネルディスカッション;膵癌取扱い規約をめぐってー膵管内腫瘍の新しい分類システムの提唱- (2010)
  • Author(s): 山口浩
  • Organizer: 第18回日本消化器関連学会週間(JDDW2010)
  • Place of Presentation: 横浜
• [Presentation] A New Classification system for Primary Intraductal Neoplasms of the Pancreas (2010)
  • Author(s): Yamaguchi H et al.
  • Organizer: 第14回国際膵臓学会・第41回日本膵臓学会大会合同会議
  • Place of Presentation: 福岡