The relationship between fascin-overexpression and RAS signaling pathway in pancreatic cancer
| Project/Area Number |
22790353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Toru 東京女子医科大学, 医学部, 教授 (30282122)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | fascin / 膵癌 / RAS信号伝達経路 / RASシグナル伝達経路 / 体細胞変異 |
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| Research Abstract |
Inhibition of RAS signaling pathway induced the fascin down-regulation in the pancreatic cancer cell-lines which normally showed fascin-overexpression. The similar results were revealed in promoter activity assay. These results indicate that fascin-overexpression in the pancreatic cancer is caused by an activated RAS signaling pathway.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Molecular characteristics and biological behaviours of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms.2011
Author(s)
Xiao HD, Yamaguchi H(double author), Dias-Santagata D, Kuboki Y, Akhavanfard S, Hatori T, Yamamoto M, Shiratori K, Kobayashi M, Shimizu M, Fernandez-Del Castillo C, Mino-Kenudson M, Furukawa T
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Journal Title
J Pathol
Volume: 224(4)
Issue: 4
Pages: 508-16
DOI
Related Report
Peer Reviewed
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[Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011
Author(s)
Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, Shin N, Ishida K, Morikawa T, MotoiF, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Harada Y, Furukawa
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Journal Title
Am J Surg Pathol
Volume: 35(12)
Issue: 12
Pages: 1812-7
DOI
Related Report
Peer Reviewed
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[Presentation] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011
Author(s)
Yamaguchi H, Furukawa T, Kuboki Y, Hatori T, Higashi M, Morikawa T, Kanno A, Orikasa H, Harada Y, Shimizu M
Organizer
4th AOPA & KPBA Joint Meeting of the 4th Asian-Oceanic Pancreas Association and 2011 annual Congress of the Korean Pancreatobiliary Association
Place of Presentation
Jeju, Korea
Related Report
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