Chemokines as novel therapeutic targets in inflammatory arthritis

• Project/Area Number: 22790388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Tohoku University
• Principal Investigator: INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 炎症 / 骨破壊 / 関節炎 / ケモカイン / 破骨細胞

Research Abstract

In this study, we examined the physiological roles of C-C chemokines in antigen-induced arthritis and osteoclast development. MIP-1α-CCR1 signaling enhanced inflammatory bone destruction and osteoclast development. Thus, CCL3-CCR1 signaling might be a molecular target for the treatment of inflammatory arthritis.

Research Products

• [Journal Article] Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing (2012)
  • Author(s): Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, Kondo T
  • Journal Title: J. Clin. Invest Volume: 122 Pages: 711-21
  • Peer Reviewed
• [Journal Article] Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing (2012)
  • Author(s): Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, Kondo T
  • Journal Title: J Clin Invest Volume: 122 Issue: 2 Pages: 711-721
  • DOI: 10.1172/jci43027
  • Peer Reviewed
• [Journal Article] Absence of IFN-g accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice (2011)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T
  • Journal Title: J. Clin. Invest Volume: 121 Pages: 2911-20
  • Peer Reviewed
• [Journal Article] Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression (2011)
  • Author(s): Inui M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Journal Title: J. Immunol Volume: 186 Pages: 423-31
  • Peer Reviewed
• [Journal Article] Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice (2011)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T
  • Journal Title: J Clin Invest Volume: 121 Issue: 7 Pages: 2911-2920
  • DOI: 10.1172/jci40782
  • Peer Reviewed
• [Journal Article] Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. (2011)
  • Author(s): Inui M., 他5名
  • Journal Title: Journal of Immunology Volume: 186 Pages: 423-431
  • Peer Reviewed
• [Presentation] Differential but competitive binding of Nogo and MHC class I to PIR-B regulates LPS-activated mast cells (2011)
  • Author(s): Natsuko Shinozaki, Masanori Inui, Shota Endo, Yuzuru Sakamoto, Kohji Kitaguchi, Kimiko Kuroki, Katsumi Maenaka, Toshiyuki Takai
  • Organizer: 日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] NogoおよびMHC class IによるPIR-Bを介した新たなマスト細胞の制御機構 (2011)
  • Author(s): 乾匡範, 篠崎夏子, 遠藤章太, 高井俊行
  • Organizer: 日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] NogoおよびMHCクラスIによるPIR-Bへの競合的結合によるマスト細胞の制御について (2011)
  • Author(s): 篠崎夏子, 乾匡範, 遠藤章太, 坂本譲, 北口公司, 高井俊行
  • Organizer: 日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] NogoおよびMHC class IによるPIR-Bを介した新たなマスト細胞の制御機構 (2011)
  • Author(s): 乾匡範, 他3名
  • Organizer: 第61回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis (2011)
  • Author(s): 近藤俊和, 石田裕子, 乾匡範, 木村章彦, 野坂みずほ, 國中由美, 向田直史
  • Organizer: 日本炎症・再生医学会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-03
• [Presentation] 関節強直症自然発症モデルマウスにおける発症機序の解明 (2010)
  • Author(s): 乾匡範
  • Organizer: 日本リウマチ学会, 北海道・東北支部学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-19
• [Presentation] 関節強直症自然発症モデルマウスにおける発症機序の解明 (2010)
  • Author(s): 乾匡範
  • Organizer: 日本リウマチ学会 北海道・東北支部学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-19
• [Presentation] Essential roles of CCL3-CCR1 signal pathways in the pathogenesis of antigen-induced arthritis (2010)
  • Author(s): Masanori Inui, Yuko Ishida, Akihiko Kimura, Naofumi Mukaida, Toshikazu Kondo
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-24
• [Presentation] Essential roles of CCL3-CCR1 signaling pathways in the pathogenesis of antigen-induced arthritis. (2010)
  • Author(s): Masanori Inui, 他4名
  • Organizer: International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Book] 骨髄球系細胞におけるMDL-1/DAP12の機能. リウマチ科 (2011)
  • Author(s): 北口公司, 遠藤章太, 乾匡範, 高井俊行
  • Publisher: 科学評論社
• [Book] 骨髄球系細胞におけるMDL-1/DAP12の機能 (2011)
  • Author(s): 乾匡範, 他3名
  • Total Pages: 5
  • Publisher: 科学評論社(リウマチ科)
• [Book] 炎症とDAP12/DAP10/FcRγ. 感染・炎症・免疫 (2010)
  • Author(s): 中村晃, 乾匡範, 高井俊行
  • Publisher: 医薬の門社
• [Remarks]
  • URL: http://www2.idac.tohoku.ac.jp/dep/expimmu/index.html