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The effect of XMRV-infection on the malignancy of tumor cells

Research Project

Project/Area Number 22790427
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SAKUMA Ryuta  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50547429)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords病原性 / XMRV / ガン化 / 悪性化
Research Abstract

XMRV is a newly identified human gamma-retrovirus cloned from a prostate cancer tissue sample. Since there was no evidence to show that XMRV infection could be a possible trigger of prostate cancer generation, we assessed if XMRV-infection increased tumor malignancy. Both the anchorage dependency of tumor cells and a cell growth efficacy under lower serum concentration was not affected by XMRV infection. Then we concluded that XMRV infection did not affect a tumor malignancy. These data agreed with some other reports published from our group and others, recently.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] No association of xenotropic murineleukemia virus-related virus withprostate cancer or chronic fatiguesyndrome in Japan2011

    • Author(s)
      Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F
    • Journal Title

      Retrovirology

      Volume: 17 ; 8 Pages: 20-20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan.2011

    • Author(s)
      Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F.
    • Journal Title

      Retrovirology

      Volume: 8(E-pub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] DEVELOPMENT OF REPLICATION-COMPETENT XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS CARRYING THE PUROMYCIN RESISTANCE GENE2011

    • Author(s)
      Ryuta Sakuma, Saori Shikama, Sayaka Sukegawa, Shoji Yamaoka
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] DEVELOPMENT OF REPLICATION-COMPETENT XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS CARRYING THE PUROMYCIN RESISTANCE GENE2011

    • Author(s)
      Ryuta Sakuma, Saori Shikama, Sayaka Sukegawa, Shoji Yamaoka
    • Organizer
      International Union of Microbiological Societies 2011 Congress XV International Congress of Virology
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] コムギ無細胞タンパク質合成系を用いた新規ガンマレトロウイルスXMRVプロテアーゼの解析2010

    • Author(s)
      松永智子、小島良績、澤崎達也、森下了、佐久間龍太、岩谷靖雅、杉浦亙、山本直樹、梁明秀
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      〓島
    • Year and Date
      2010-11-09
    • Related Report
      2011 Final Research Report
  • [Remarks] 研究室web site内に、本研究課題に関するページを作成予定である。

    • URL

      http://www.tmd.ac.jp/med/mmb/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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