| Project/Area Number |
22790454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUKUI Ryutaro 東京大学, 医科学研究所, 特任助教 (60554508)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 自然免疫 / Toll-like receptor / Unc93 homolog B1 / 自然炎症 / サイトカイン / 内因性リガンド / 新規分子探索 / 肝炎 / Th17 / 急性肝炎 / 自己免疫疾患 / 骨髄増殖性疾患 |
|---|
| Research Abstract |
We generated Unc93b1D34A/D34A mutant mouse to analyze the significance of reciprocal TLR7/TLR9 balance in vivo. As results, various phenotypes were developed in these mice spontaneously and over half of mice died within 1 year because of TLR7 hyper-response. For example, hepatitis, splenomegaly, thrombocytopenia, and glomerulonephritis were observed. From these results, it is confirmed that reciprocal TLR7/TLR9 balance is an essential mechanism for avoiding lethal homeostatic inflammation.
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