Analysis of the mechanism for controlling reciprocal balance in nucleic acid sensing-innate immune system
| Project/Area Number |
22790454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUKUI Ryutaro 東京大学, 医科学研究所, 特任助教 (60554508)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 自然免疫 / Toll-like receptor / Unc93 homolog B1 / 自然炎症 / サイトカイン / 内因性リガンド / 新規分子探索 / 肝炎 / Th17 / 急性肝炎 / 自己免疫疾患 / 骨髄増殖性疾患 |
|---|
| Research Abstract |
We generated Unc93b1D34A/D34A mutant mouse to analyze the significance of reciprocal TLR7/TLR9 balance in vivo. As results, various phenotypes were developed in these mice spontaneously and over half of mice died within 1 year because of TLR7 hyper-response. For example, hepatitis, splenomegaly, thrombocytopenia, and glomerulonephritis were observed. From these results, it is confirmed that reciprocal TLR7/TLR9 balance is an essential mechanism for avoiding lethal homeostatic inflammation.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking.2011
Author(s)
Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.2010
Author(s)
Makiko Hirai, Norimitsu Kadowaki, Toshio Kitawaki, Haruyuki Fujita, Akifumi Takaori-Kondo, Ryutaro Fukui, Kensuke Miyake, Takahiro Maeda, Shimeru Kamihira, Yoshiki Miyachi, Takashi Uchiyama.
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Journal Title
Blood
Volume: 117
Pages: 500-509
Related Report
Peer Reviewed
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[Presentation] Unc93 homolog B1restricts lethal homeostatic inflammation by regulating TLR7 and TLR9 reciprocally2011
Author(s)
Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
Organizer
第40回日本免疫学会学術集会ワークショップ
Place of Presentation
幕張メッセ,千葉県
Year and Date
2011-11-28
Related Report
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[Presentation] Unc93 homolog B1 restricts lethal homeostatic inflammation by regulating TLR7 and TLR9 reciprocally2011
Author(s)
Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake
Organizer
第40回日本免疫学会学術集会ワークショップ
Place of Presentation
幕張メツセ・千葉
Year and Date
2011-11-28
Related Report
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