• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulation of autoimmune response by an Ig domain-containing sialomucin, nepmucin

Research Project

Project/Area Number 22790466
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

UMEMOTO Eiji  大阪大学, 医学系・研究科, 助教 (90452440)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords免疫寛容・自己免疫 / 高内皮性静脈 / リンパ球トラフィッキング / 接着分子 / 白血球移動 / 高内皮細静脈 / 自己免疫応答 / 免疫学 / リンパ球動態 / アポトーシス
Research Abstract

Nepmucin is an Ig-domain-containing adhesion molecule expressed in certain types of vascular endothelial cells and promotes lymphocyte transendothelial migration in vitro. We found that nepmucin binds to phosphatidylserine, which appears on the outer leaflet of the plasma membrane in apoptotic cells. Nepmucin promotes the uptake of apoptotic cells by endothelial cells of lymph node high endothelial venule. Nepmucin-deficient mice showed elevated autoantibody production in an age-dependent manner. Collectively, our findings indicate that nepmucin is involved in autoimmune response.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7-and CXCR4-mediated signaling2012

    • Author(s)
      *Umemoto E., * Otani K., Ikeno T., Garcia N. V., Hayasaka H., Bai Z., Jang M. H., Tanaka T., Nagasawa T., Ueda K., & Miyasaka M.(* equal contribution)
    • Journal Title

      J. Immunol

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SIRPτ/ CD172a Regulates Eosinophil Homeostasis2011

    • Author(s)
      Garcia N. V., Umemoto E., Saito Y., Yamasaki M., Hata E., Matozaki T., Murakami M., Jung Y. J., Woo S. Y., Seoh J. Y., Jang M. H., Aozasa K., & Miyasaka M.
    • Journal Title

      J. Immunol

      Volume: 187 Pages: 2268-2277

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel Regulators of Lymphocyte Trafficking across High Endothelial Venules2011

    • Author(s)
      Umemoto, E., Hayasaka H., Bai Z., Cai L., Yonekura S., Peng X., Takeda A., Tohya K. & Miyasaka M.
    • Journal Title

      Crit. Rev. Immunol

      Volume: 31 Pages: 147-169

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel regulators of lymphocyte trafficking across high endothelial venule2011

    • Author(s)
      Umemoto E., Hayasaka H., et al
    • Journal Title

      Critical Reviews in Immunology

      Volume: 31 Pages: 147-169

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIRPα/CD172a regulates eosinophil homeostasis2011

    • Author(s)
      Verjan G.M., Umemoto, et al
    • Journal Title

      The Journal of Immunology

      Volume: 187 Pages: 2268-2277

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microanatomy of lymphocyte-endothelial interactions at the high endothelial venules of lymph nodes2010

    • Author(s)
      Tohya K., Umemoto E., & Miyasaka M.
    • Journal Title

      Histol. Histopathol

      Volume: 25 Pages: 781-794

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microanatomy of lymphocyte-endothelial interactions at the high endothelial venules of lymph nodes2010

    • Author(s)
      Tohya K., Umemoto E., et al.
    • Journal Title

      Histology and Histopathology

      Volume: 25 Pages: 781-794

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL122012

    • Author(s)
      梅本英司
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Breckenridge, Colorado
    • Year and Date
      2012-01-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL122012

    • Author(s)
      Umemoto E. et al.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Colorado, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL122011

    • Author(s)
      梅本英司
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL122011

    • Author(s)
      梅本英司, 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] Nepmucin/ CD300LG promotes LPA-induced lymphocyte transcellular migration across HEV endothelial cells2011

    • Author(s)
      竹田彰、梅本英司, 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of PV-1 and neuropilin-1 in lymphocyte transendothelial migration across HEVs2011

    • Author(s)
      池野嵩、梅本英司, 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] Signal regulating protein alpha(SIRPτ)/ CD172a regulates eosinophil homeostasis2011

    • Author(s)
      Verjan Garcia N, 梅本英司, 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] In vivo inhibition of the autotaxin/ LPA axis results in inhibition of lymphocyte transmigration across high endothelial venules2011

    • Author(s)
      秦枝里奈、白忠彬、蔡林君、梅本英司, 他
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] HEV上の新しいシアロムチンnepmucin2010

    • Author(s)
      梅本英司、宮坂昌之
    • Organizer
      第34回日本リンパ学会総会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nepmucin mediates uptake of apoptotic cells in the endothelial cells of high endothelial venules2010

    • Author(s)
      梅本英司, 他
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] SIRPτ/ SHPS-1 is strongly expressed in mouse eosinophils2010

    • Author(s)
      Verjan Garcia N, 梅本英司, 他
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of a novel HEV-associated sialomucin, nepmucin2010

    • Author(s)
      梅本英司、宮坂昌之
    • Organizer
      第34回日本リンパ学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/orgctl/www/index-jp.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi