Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.
| Project/Area Number |
22790475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OMORI Miyuki (MIYAKE Miyuki) 東京女子医科大学, 医学部, 助教 (30462667)
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| Research Collaborator |
YAMASHITA Masakatsu 愛媛大学, 医学部, 教授 (00311605)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー / アトピー性皮膚炎 / Th2細胞 / Th2サイトカイン / TSLP / アレルギー疾患 / 表皮ケラチノサイト |
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| Research Abstract |
TSLP has been observed in the skin lesion of atopic-dermatitis patients. We have investigated roles of Th2 differentiation in instability of the epidermis under a high level of TSLP expression in keratinocytes. The results demonstrate that Th2-mediated cytokines IL-4 or IL-13 are capable of down-regulating the expression of structural molecules of differentiating kerationcytes through STAT6 and/or ERK-MAPK signaling.
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Report
(4 results)
Research Products
(9 results)
