2012 Fiscal Year Final Research Report
Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.
| Project/Area Number |
22790475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OMORI Miyuki (MIYAKE Miyuki) 東京女子医科大学, 医学部, 助教 (30462667)
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| Research Collaborator |
YAMASHITA Masakatsu 愛媛大学, 医学部, 教授 (00311605)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アレルギー |
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| Research Abstract |
TSLP has been observed in the skin lesion of atopic-dermatitis patients. We have investigated roles of Th2 differentiation in instability of the epidermis under a high level of TSLP expression in keratinocytes. The results demonstrate that Th2-mediated cytokines IL-4 or IL-13 are capable of down-regulating the expression of structural molecules of differentiating kerationcytes through STAT6 and/or ERK-MAPK signaling.
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Research Products
(4 results)
