2012 Fiscal Year Final Research Report
Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.
| Project/Area Number |
22790475
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
OMORI Miyuki (MIYAKE Miyuki) 東京女子医科大学, 医学部, 助教 (30462667)
|
|---|
| Research Collaborator |
YAMASHITA Masakatsu 愛媛大学, 医学部, 教授 (00311605)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | アレルギー |
|---|
| Research Abstract |
TSLP has been observed in the skin lesion of atopic-dermatitis patients. We have investigated roles of Th2 differentiation in instability of the epidermis under a high level of TSLP expression in keratinocytes. The results demonstrate that Th2-mediated cytokines IL-4 or IL-13 are capable of down-regulating the expression of structural molecules of differentiating kerationcytes through STAT6 and/or ERK-MAPK signaling.
|
