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2012 Fiscal Year Final Research Report

Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.

Research Project

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Project/Area Number 22790475
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionTokyo Women's Medical University

Principal Investigator

OMORI Miyuki (MIYAKE Miyuki)  東京女子医科大学, 医学部, 助教 (30462667)

Research Collaborator YAMASHITA Masakatsu  愛媛大学, 医学部, 教授 (00311605)
Project Period (FY) 2010 – 2012
Keywordsアレルギー
Research Abstract

TSLP has been observed in the skin lesion of atopic-dermatitis patients. We have investigated roles of Th2 differentiation in instability of the epidermis under a high level of TSLP expression in keratinocytes. The results demonstrate that Th2-mediated cytokines IL-4 or IL-13 are capable of down-regulating the expression of structural molecules of differentiating kerationcytes through STAT6 and/or ERK-MAPK signaling.

  • Research Products

    (4 results)

All 2013 2012 2011

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] Mouse models of allergic diseases: TSLP and its functional roles2012

    • Author(s)
      Miyuki Omori-Miyake and Steven F Ziegler.
    • Journal Title

      Allergol. Int

      Volume: 61(1) Pages: 27-34

  • [Presentation] IL-4- or IL-13-mediated modification of structural molecules in murine and human epidermal keratinocyte. The American Association of Immunologists2013

    • Author(s)
      Miyuki Omori-Miyake, Masakatsu Yamashita and Junji Yagi
    • Organizer
      100th Annual Meeting
    • Place of Presentation
      米国ハワイ州
    • Year and Date
      20130503-07
  • [Presentation] Possible mechanisms of epidermal fragility in atopic dermatitis caused by IL-4 and IL-132012

    • Author(s)
      大森深雪, 山下政克, 八木淳二
    • Organizer
      第41回日本免疫学会総会学術総会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      20121205-07
  • [Presentation] IL-4 and IL-13 modulate intermediate stage of epidermal keratinocyte differentiation2011

    • Author(s)
      大森深雪, 山下政克, 八木淳二
    • Organizer
      第40回日本免疫学会総会学術総会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      20111127-29

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Published: 2014-08-29  

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