Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.

• Project/Area Number: 22790475
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: OMORI Miyuki (MIYAKE Miyuki) 東京女子医科大学, 医学部, 助教 (30462667)
• Research Collaborator: YAMASHITA Masakatsu 愛媛大学, 医学部, 教授 (00311605)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アレルギー / アトピー性皮膚炎 / Th2細胞 / Th2サイトカイン / TSLP / アレルギー疾患 / 表皮ケラチノサイト

Research Abstract

TSLP has been observed in the skin lesion of atopic-dermatitis patients. We have investigated roles of Th2 differentiation in instability of the epidermis under a high level of TSLP expression in keratinocytes. The results demonstrate that Th2-mediated cytokines IL-4 or IL-13 are capable of down-regulating the expression of structural molecules of differentiating kerationcytes through STAT6 and/or ERK-MAPK signaling.

Research Products

• [Journal Article] Mouse models of allergic diseases: TSLP and its functional roles (2012)
  • Author(s): Miyuki Omori-Miyake and Steven F Ziegler.
  • Journal Title: Allergol. Int Volume: 61(1) Pages: 27-34
• [Journal Article] Mouse Models of Allergic Diseases: TSLP and Its Functional Roles (2012)
  • Author(s): Miyuki Omori-Miyake, Steven F Ziegler
  • Journal Title: Allergology International Volume: 61 Issue: 1 Pages: 27-34
  • DOI: 10.2332/allergolint.11-RAI-0374
  • NAID: 130004873039
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] アトピー型喘息の病態形成におけるTSLP(Thymic stromal lymphopoietin)の役割 (2010)
  • Author(s): 大森深雪
  • Journal Title: IgE practice in asthma Volume: 4 Pages: 3-7
• [Presentation] IL-4- or IL-13-mediated modification of structural molecules in murine and human epidermal keratinocyte. The American Association of Immunologists (2013)
  • Author(s): Miyuki Omori-Miyake, Masakatsu Yamashita and Junji Yagi
  • Organizer: 100th Annual Meeting
  • Place of Presentation: 米国ハワイ州
• [Presentation] IL-4- or IL-13-mediated modification of structural molecules in murine and human epidermal keratinocyte. (2013)
  • Author(s): Miyuki Omori-Miyake
  • Organizer: The American Association of Immunologists, 100th Annual Meeting
  • Place of Presentation: Hawaii, USA
• [Presentation] Possible mechanisms of epidermal fragility in atopic dermatitis caused by IL-4 and IL-13 (2012)
  • Author(s): 大森深雪, 山下政克, 八木淳二
  • Organizer: 第41回日本免疫学会総会学術総会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] Possible mechanisms of epidermal fragility in atopic dermatitis caused by IL-4 and IL-13. (2012)
  • Author(s): Miyuki Omori-Miyake
  • Organizer: 第41回日本免疫学会総会学術総会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] IL-4およびIL-13は表皮ケラチノサイト分化の中間段階を調節している (2011)
  • Author(s): 大森深雪
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] IL-4 and IL-13 modulate intermediate stage of epidermal keratinocyte differentiation (2011)
  • Author(s): 大森深雪, 山下政克, 八木淳二
  • Organizer: 第40回日本免疫学会総会学術総会
  • Place of Presentation: 千葉県千葉市