Analysis of BCR degradation by a lysosomal protein LAPTM5
| Project/Area Number |
22790482
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OUCHIDA Rika 独立行政法人理化学研究所, 免疫多様性研究チーム, 研究員 (80391887)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リソソーム / B細胞抗原受容体 / B細胞活性化 / 自己免疫疾患 / B cell receptor(BCR) / lysosome / B cell activation / B cell receptor (BCR) |
|---|
| Research Abstract |
Modulation of antigen receptor expression is an important mechanism for the regulation of immune responses. We demonstrate that LAPTM5 regulates BCR levels and immune response by BCR degradation in lysosomes and LAPTM5-mediated BCR downmodulation is an important mechanism to prevent B cell hyperactivation and autoantibody production.
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Report
(3 results)
Research Products
(7 results)
