Study on epigenetic changes in fetal life evoked by gestational infection or malnutrition

• Project/Area Number: 22790541
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU-FURUSAWA Hana 東京大学, 医学(系)研究科(研究院), 助教 (80401032)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥6,003,052 (Direct Cost: ¥4,617,733、Indirect Cost: ¥1,385,319); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,973,052 (Direct Cost: ¥1,517,733、Indirect Cost: ¥455,319); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 胎生期 / 次世代 / 出産 / 血族婚 / 妊娠 / インドネシア / エピジェネティク / メチル化 / マラリア

Research Abstract

The aim of this study was to explore any alterations or deleterious effects on survival rate during growth and late-onset gene expressions in future generations by certain embryonal environments or child-care after birth. Both community-based human study and animal experiments were conducted in parallel. A cohort study in Sumba, Indonesia, revealed that consanguineous marriages might decrease the survival rate of the offspring who lived over 5 years old, but lead to high fertility. Bangladeshi mother-infant pairs exposed to inorganic arsenic (iAs) were investigated to examine susceptibility to iAs, followed by experiments for iAs exposure to mice.

Research Products

• [Journal Article] Arsenic exposure increases maternal but not cord serum immunoglobulin G level in Bangladesh (2015)
  • Author(s): Ser, PH., Bilkis, B., Fatema, J., Fatema, K., Nasrin, R., Rabeya, Y., Furusawa, H., Liaquat, A., Akhtar, A., Watanabe, C.
  • Journal Title: Pediatrics International Volume: 57(1)(in press) Issue: 1 Pages: 119-125
  • DOI: 10.1111/ped.12396
  • Peer Reviewed
• [Journal Article] Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat (2014)
  • Author(s): Nakamura, M., Hachiya, N., Murata, KY., Nakanishi, I., Kondo, T., Yasutake, A., Miyamoto, KI., Ser, PH., Omi, S., Furusawa, H., Watanabe, C., Usuki, F., and Sakamoto, M.
  • Journal Title: Environment International Volume: 68 Pages: 25-32
  • DOI: 10.1016/j.envint.2014.03.005
  • Peer Reviewed
• [Journal Article] Home environment and prenatal exposure to lead, arsenic and zinc on the neurodevelopment of six-month-old infants living in Chitwan Valley (2014)
  • Author(s): Parajuli, RP., Fujiwara, T., Umezaki, M., Furusawa, H., and Watanabe, C.
  • Journal Title: Nepal. Neurotoxicology and Teratology Volume: 41 Pages: 89-95
  • DOI: 10.1016/j.ntt.2013.12.006
  • Peer Reviewed
• [Journal Article] Cord blood levels of toxic and essential trace elements and their determinants in the Terai region of Nepal : a birth cohort study (2012)
  • Author(s): Parajuli, RP., Fujiwara, T., Umezaki, M., Furusawa, H., Ser, PH, and Watanabe, C.
  • Journal Title: Biological Trace Element Research Volume: 147(1-3) Issue: 1-3 Pages: 75-83
  • DOI: 10.1007/s12011-011-9309-1
  • Peer Reviewed
• [Journal Article] Facial resemblance and attractiveness : an experimental study in rural Indonesia (2011)
  • Author(s): Nojo, S., Ihara, Y., Furusawa, H., Akamatsu, S., and Ishida, T.
  • Journal Title: Letters on Evolutionary Behavioral Science Volume: 2(1) Issue: 1 Pages: 9-12
  • DOI: 10.5178/lebs.2011.11
  • Peer Reviewed
• [Journal Article] Facial resemblance and attractiveness: an experimental study in rural Indonesia. (2011)
  • Author(s): Nojo, S., Ihara, Y., Furusawa (Shimizu), H., Akamatsu, S., and Ishida, T.
  • Journal Title: Letters on Evolutionary Behavioral Science Volume: 2(1) Pages: 9-12
  • Peer Reviewed
• [Journal Article] Communicable and non-communicable diseases in the Solomon Islands villages during recovery from a massive earthquake in April 2007. (2011)
  • Author(s): Furusawa, T., Furusawa (Shimizu), H., Eddie, R., Tuni, M., Pitakaka, F., and Aswani, S.
  • Journal Title: The New Zealand Medical Journal Volume: 124(1333) Pages: 17-28
  • Peer Reviewed
• [Presentation] Gender disparity in inorganic arsenic-induced oxidative stress among Bangladeshi population exposed to high arsenic through drinking water (2012)
  • Author(s): Sultana, N., Watanabe, C., Furusawa, H., Umezaki, M., and Inaoka, T.
  • Organizer: The 6th International Congress of Asian Society of Toxigology
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2012-07-19
• [Presentation] Health risk assessment of reuse water consumption in Klongjik municipality (2012)
  • Author(s): Morknoy, D., Furusawa, H., Kreela, N., Watanabe, C., and Yamamoto, K.
  • Organizer: Workshop on Development of Water Reuse Technology and Management
  • Place of Presentation: Rayong, Thailand
  • Year and Date: 2012-03-27
• [Presentation] Time- and space-saving method for sampling, storage, and identification of water-borne pathogenic bacteria by using detection papers : with a case report of Indonesia (2012)
  • Author(s): Furusawa, T., Nakamura, S., and Furusawa, H.
  • Organizer: The 10th International Symposium Southeast Asian Water Environment
  • Place of Presentation: Hanoi, Vietnam
• [Presentation] Variation in quality of drinking water utilized by residents nearby Bang Pa-In Industrial Estate in Thailand. International Water Association World Congress on Water (2012)
  • Author(s): Furusawa, H., Morknoy, D., Chou, PH., Tammatak, T., Sirikanyaporn, S., Jaikanlaya, C., Tantrakarnapa, K., Watanabe, C., and Yamamoto, K.
  • Organizer: Climate and Energy 2012
  • Place of Presentation: Dublin, Ireland
• [Presentation] タイの工業地帯の居住者における飲料水の利用と糖代謝に関わるバイオマーカーとの関連 (2012)
  • Author(s): チュ・ペイシェン, 古澤華, モークノイ・デイジー, ジャイカンラヤ・チャート, タントゥラカルナパ・クライチャット, 渡辺知保
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] タイ工業団地周辺住民が自宅で使い分ける水の水質分析 (2012)
  • Author(s): 古澤華, チュ・ペイシェン, モークノイ・デイジー, ジャイカンラヤ・チャート, タントゥラカルナパ・クライチャット, 渡辺知保
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] Gender disparity in inorganic arsenic-induced oxidative stress among Bangladeshi population exposed to high arsenic through drinking water. (2012)
  • Author(s): Sultana, N., Watanabe, C., Furusawa, H., Umezaki, M., and Inaoka, T.
  • Organizer: The 6th International Congress of Asian Society of Toxigology
  • Place of Presentation: Sendai, Japan
• [Presentation] Variation in quality of drinking water utilized by residents nearby Bang Pa-In Industrial Estate in Thailand. (2012)
  • Author(s): Furusawa, H., Morknoy, D., Chou, PH., Tammatak, T., Sirikanyaporn, S., Jaikanlaya, C., Tantrakarnapa, K., Watanabe, C., and Yamamoto, K.
  • Organizer: International Water Association World Congress on Water, Climate and Energy
  • Place of Presentation: Dublin, Ireland
• [Presentation] タイ工業団地周辺住民が自宅で使い分ける水の水質分析. (2012)
  • Author(s): 古澤（清水）華, チュ・ペイシェン, モークノイ・デイジー, ジャイカンラヤ・チャート, タントゥラカルナパ・クライチャット, 渡辺知保.
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学（京都府京都市）
• [Presentation] Effects of consanguineous marriages on offspring survival among Sumbanese in Indonesia (2011)
  • Author(s): Furusawa, H., Ihara, Y., Soemantri, AG., and Ishida, T.
  • Organizer: 96th Ecological Society of America Annual Meeting
  • Place of Presentation: Austin, Texas, USA
  • Year and Date: 2011-08-10
• [Presentation] The role of gender in inorganic arsenic induced oxidative stress among Bangladeshi population exposed to high arsenic through drinking water (2011)
  • Author(s): Sultana, N., Watanabe, C., Furusawa, H., Umezaki, M., and Inaoka, T.
  • Organizer: International Society for Environmental Epidemiology
  • Place of Presentation: Barcelona, Spain
• [Presentation] Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA) (2011)
  • Author(s): Tasmin, S., Furusawa, H., Inoue, Y., Faruquee, MH., Chou, PH., and Watanabe, C.
  • Organizer: International Society for Environmental Epidemiology
  • Place of Presentation: Barcelona, Spain
• [Presentation] Effects of consanguineous marriages on offspring survival among Sumbanese in Indonesia. (2011)
  • Author(s): Furusawa (Shimizu), H., Ihara, Y., Soemantri, AG., and Ishida, T.
  • Organizer: 96th Ecological Society of America Annual Meeting
  • Place of Presentation: オースティンコンベンションセンター（アメリカ合衆国）
• [Presentation] 顔の類似性と魅力 (2010)
  • Author(s): 井原泰雄, 能城沙織, 清水華, 赤松茂, 石田貴文
  • Organizer: 第3回日本人間行動進化学会
  • Place of Presentation: 神戸
• [Presentation] スンバ人における顔の類似性に依存した配偶者選択 (2010)
  • Author(s): 能城沙織, 井原泰雄, 清水華, 赤松茂, 石田貴文
  • Organizer: 第29回日本動物行動学会
  • Place of Presentation: 沖縄
• [Book] トキシコキネティクスとトキシコダイナミクス. 熊谷嘉人, 姫野誠一郎, 渡辺知保編, 「毒性の科学-分子・細胞から人間集団まで」 (2014)
  • Author(s): 古澤華, 渡辺知保
  • Publisher: 東京大学出版会