The expression and role ofTGF‐β1 binding protein subtype on carcinogenesis

• Project/Area Number: 22790542
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Kanazawa University
• Principal Investigator: HIGASHI Tomomi 金沢大学, 医学系, 助教 (20293342)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: TGF-β1 / LTBP-1L / 発癌 / TGF-β / LTBP-1 / 癌 / TGF-ss1 / LTBP-1S / 胃癌

Research Abstract

Knockdown of LTBP-1L or LTBP-1S in cancer cell lines including stomach cancer, ovarian cancer, uterine cancer, colorectal cancer, had no remarkable change in cell shape, cell growth and cell invasion activity. Forced expression of LTBP-1L or LTBP-1S also showed no remarkable effect on cancer cell lines. On the other hand, there was correlation between LTBP-1 expression and cancer - stroma relationship of stomach cancer by immunohistochemical analysis in clinical samples (p < 0.01). Thus, it was suggested that LTBP-1 can be a candidate of the diagnostic marker and the target of medical treatment. However, further studies were required to determine the LTBP-1L and LTBP-1S function.

Research Products

• [Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy (2013)
  • Author(s): Kitano A
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: 15-15
  • DOI: 10.1371/journal.pone.0055289
  • URL: http://www.kanazawa-u.ac.jp/~ganken/shuyoseigyo/
  • Peer Reviewed
• [Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy (2013)
  • Author(s): Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T.
  • Journal Title: PLoS One Volume: 8
  • NAID: 120005253831
  • Peer Reviewed
• [Journal Article] Repeated Exposure to Cruciferous Allyl Nitrile Protects against Chemically Induced Skin Inflammation in the Mouse (2012)
  • Author(s): Tanii H, Hi gashi T, Demura M, Saijoh K
  • Journal Title: Food and Nutrition Sciences Volume: 3 Issue: 08 Pages: 1037-1042
  • DOI: 10.4236/fns.2012.38137
  • Peer Reviewed
• [Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy (2012)
  • Author(s): A.Kitano, T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai, K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto
  • Journal Title: Molecular Cancer Therapeutics Volume: (in press)
  • NAID: 120005253831
  • Peer Reviewed
• [Journal Article] Effect of KOSA on chronic cough (2012)
  • Author(s): T.Higashi, Y.Kambayashi, M.Fujimura, T.Yoshizaki, K.Hayakawa, K.Saijoh, Y.Hitomi, F.Kobayashi, Y.Michigami, H.Nakamura
  • Journal Title: Jpn.J.Hyg. Volume: Vol.67 Pages: 287-287
• [Journal Article] Monthly changes in concentrations of polycyclic aromatic hydrocarbons and metals in ambient dust and characteristics of them on Asian dust day (2012)
  • Author(s): Y.Kambayashi, T.Higashi, M.Fujimura, T.Yoshizaki, K.Hayakawa, K.Saijoh, Y.Hitomi, F.Kobayashi, Y.Michigami, H.Nakamura
  • Journal Title: Jpn.J.Hyg. Volume: Vol.67 Pages: 306-306
• [Journal Article] Preconditioning with subneurotoxic allyl nitrile: Protection against allyl nitrile neurotoxicity (2010)
  • Author(s): Tanii H, Higashi T and Saijoh K
  • Journal Title: Food and Chemical Toxicology. Volume: 48 Issue: 2 Pages: 750-754
  • DOI: 10.1016/j.fct.2009.12.010
  • Peer Reviewed
• [Journal Article] Phylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region (2010)
  • Author(s): T. Maki
  • Journal Title: Suzu City, Sci. Total Environment Volume: 408 Issue: 20 Pages: 4556-4562
  • DOI: 10.1016/j.scitotenv.2010.04.002
  • Peer Reviewed
• [Journal Article] Phylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region, Suzu City (2010)
  • Author(s): T.Maki, S.Susuki, F.Kobayashi, M.Kakikawa, Y.Tobo, M.Yamada, T.Higashi, A..Matsuki, C.Hong, H.Hasegawa, Y.Iwasaka.
  • Journal Title: Science of the Total Environment Volume: 408 Pages: 4556-4562
  • Peer Reviewed
• [Journal Article] Preconditioning with subneurotoxic allyl nitrile : Protection against ally I nitrile neurotoxicity. (2010)
  • Author(s): H.Tanii, T.Higashi, K.Saijoh
  • Journal Title: Food and Chemical Toxicology Volume: 48 Pages: 750-754
  • Peer Reviewed
• [Presentation] Health Effect of Kosa Aerosol. (2012)
  • Author(s): Higashi T, Kambayashi Y, Fujimura M,Ohkura N, Yoshizaki T, Nakanishi S, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Asakura H,Yamazaki M, Mitoma J,Horii M and Nakamura H.
  • Organizer: International Symposium on Aerosols in East Asia and their Impacts on Plants and Human Health
  • Place of Presentation: Tokyo University of Agriculture and Technology, Tokyo,Japan.
  • Year and Date: 2012-11-24
• [Presentation] The research of atmosphere bioaerosol over Antarctica (2012)
  • Author(s): F.Kobayashi, T.Maki, M.Kakikawa, M.Yamada, A.Matsuki, T.Naganuma, T.Higashi., Y. Iwasaka
  • Organizer: 5th International Symposium on the Environment of the Rim-Japan Sea Regions
  • Place of Presentation: Kanazawa University (Ishikawa)
  • Year and Date: 2012-02-04
• [Presentation] The research of atmosphere bioaerosol over Antarctica (2012)
  • Author(s): Kobayashi F, Maki T, Kakikawa M, Yamada M, Matsuki A, Naganuma T, Higashi T, Iwasaka Y
  • Organizer: 5th International Symposium on the Environment of the Rim-Japan Sea Regions
  • Place of Presentation: Kanazawa University, Kanazawa, Japan
  • Year and Date: 2012-02-03
• [Presentation] 黄砂による健康影響-慢性咳嗽の症状への影響- (2012)
  • Author(s): 東朋美、神林康弘、藤村政樹、大倉徳幸、吉崎智一、中西清香、西條清史、早川和一、人見嘉哲、小林史尚、道上義正、朝倉大貴, 山崎政美,三苫純子、岡田源作、中村裕之
  • Organizer: 東アジアにおけるエアロゾルの植物・人間系へのインパクト第2回シンポジウム
  • Place of Presentation: 京都大学百周年時計台記念館(京都府)
  • Year and Date: 2012-01-26
• [Presentation] 大気粉塵中多環芳香族炭化水素類と重金属の月変動および黄砂日の特徴 (2012)
  • Author(s): 神林康弘、東朋美、藤村政樹、大倉徳幸、吉崎智一、中西清香、西條清史、早川和一、人見嘉哲、小林史尚、道上義正、朝倉大貴,山崎政美, 三苫純子、岡田源作、中村裕之
  • Organizer: 東アジアにおけるエアロゾルの植物・人間系へのインパクト第2回シンポジウム
  • Place of Presentation: 京都大学百周年時計台記念館(京都府)
  • Year and Date: 2012-01-26
• [Presentation] 東アジアの大気研究:地理的条件と研究活動 (2011)
  • Author(s): 岩坂泰信, 松木篤, 小林史尚, 牧輝弥, 柿川真紀子,東朋美, 山田丸, 定永靖宗
  • Organizer: 北陸地域における環境の計測と保全に関する研究拠点形成第1回シンポジューム
  • Place of Presentation: 福井工業大学(福井県)
  • Year and Date: 2011-10-29
• [Presentation] 南極域の風送バイオエアロゾル実相調査 (2011)
  • Author(s): 小林史尚、岩坂泰信、牧輝弥、柿川真紀子、山田丸、東朋美、長沼毅、松木篤
  • Organizer: 第5回南極観測シンポジウム
  • Place of Presentation: 国立統計数理研究所(東京都)
  • Year and Date: 2011-10-06
• [Presentation] 黄砂とともに長距離輸送する微生物 (2011)
  • Author(s): 岩坂泰信, 山田丸, 小林史尚, 牧輝弥, 柿川眞紀子, 東朋美
  • Organizer: 日本農業工学会第27回シンポジューム・日本学術会議公開シンポジューム「地球環境・気候変動と農業環境工学」
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-09-21
• [Presentation] 黄砂バイオエアロゾルの健康影響調査 (2011)
  • Author(s): 東朋美
  • Organizer: 黄砂現象の環境・健康影響,微生物および化学物質の長距離移動,総合地球環境学研究所中国環境問題研究拠点,地球研プロジェクト
  • Place of Presentation: 総合地球環境学研究所(京都府)
  • Year and Date: 2011-04-15
• [Presentation] Pathological role for deregulated glycogen synthase kinase (GSK) 3b in pancreatic cancer proliferation and invasion (2010)
  • Author(s): A Kitano, T Shimasaki, Y Chikano, M Nakada, T Higashi, Y Ishigaki, Y Endo, Y Sai , K Miyamoto, Y Motoo, KKawakami, T Minamoto
  • Organizer: 69th Annual Meeting of the Japanease Cancer Association
  • Place of Presentation: Osaka International Convention Center, Osaka, Japan
  • Year and Date: 2010-09-24
• [Presentation] Pathological role for deregulated glycogen synthase kinase (GSK) 3β in pancreatic cancer proliferation and invasion (2010)
  • Author(s): A Kitano, T Shimasaki, Y Chikano, M Nakada, T Higashi, Y Ishigaki, Y Endo, Y Sai, K Miyamoto, Y Motoo, K Kawakami, T Minamoto
  • Organizer: 69^<th> Annual Meeting of the Japanease Cancer Association
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] Health Effect of Kosa Aerosol
  • Author(s): Higashi T, Kambayashi Y, Fujimura M, Ohkura N, Yoshizaki T, Nakanishi S, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Asakura H, Yamazaki M, Mitoma J,Horii M and Nakamura H
  • Organizer: International Symposium on Aerosols in East Asia and their Impacts on Plants and Human Health,
  • Place of Presentation: Tokyo University of Agriculture and Technology, Tokyo, Japan.
• [Presentation] Characteristics of polycyclic aromatic hydrocarbons and heavy metals in total suspended particulate during Asian dust period in Japan
  • Author(s): Kambayashi Y, Higashi T, et al.
  • Organizer: International Symposium on Aerosols in East Asia and their Impacts on Plants and Human Health,
  • Place of Presentation: Tokyo University of Agriculture and Technology, Tokyo, Japan.
• [Presentation] 慢性咳嗽患者における黄砂のアレルギー症状への影響
  • Author(s): 東朋美、神林康弘、大倉徳幸、藤村政樹、西條清史、早川和一、小林史尚、道上義正、人見嘉哲、中村裕之
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学、石川県
• [Presentation] 浮遊粒子状物質濃度や多環芳香族炭化水素類濃度に影響する気象因子の検討
  • Author(s): 神林康弘、道上義正、東朋美、堀井雅恵、大倉徳幸、藤村政樹、早川和一、小林史尚、人見嘉哲、中村裕之
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学、石川県
• [Book] Environmental Health and Education for Sustainable Development (Nakamura H, Suzuki K,Hayakawa K, eds) (2012)
  • Author(s): Higashi T, Saijoh K. Health Effects of Asian Dust (Kosa)
  • Publisher: Kanazawa e-Publishing Co. Ltd
• [Book] Several tips to stay healthy abroad In: Environmental Health and Education for Sustainable Development (Nakamura H, Suzuki K, Hayakawa K, eds) (2012)
  • Author(s): Saijoh K, Higashi T.
  • Publisher: Kanazawa e-Publishing Co. Ltd
• [Book] Health Effects of Asian Dust (Kosa). In: Environmental Health and Education for Sustainable Development (2012)
  • Author(s): Higashi T, Saijoh K
  • Total Pages: 76
  • Publisher: Kanazawa e-Publishing Co. Ltd., Kanazawa, Japan
• [Book] Several tips to stay healthy abroad. In: Environmental Health and Education for Sustainable Development (2012)
  • Author(s): Saijoh K, Higashi T
  • Total Pages: 76
  • Publisher: Kanazawa e-Publishing Co. Ltd., Kanazawa, Japan
• [Patent(Industrial Property Rights)] 遺伝子多型およびその用途 (2013)
  • Inventor(s): 東朋美、西條清史、京哲、井上正樹
  • Industrial Property Rights Holder: 金沢大学
  • Acquisition Date: 2013-01-11