| Project/Area Number |
22790552
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
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| Research Institution | National Institute for Environmental Studies |
|---|
Principal Investigator |
ITO Tomohiro 独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (60391067)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | iPS細胞 / 造血幹細胞 / フタル酸エステル / エストロゲン受容体 / ペルオキシゾーム増殖剤応答性受容体 / ディーゼル排気微粒子 |
|---|
| Research Abstract |
By using iPS cells, effects of phthalate esters on the hematopoiesis were examined. In that system, DEHP suppressed the appearance of hematopoietic progenitor from iPS cells while MEHP, a metabolite of DEHP, accelerated it. It was also suggested that their effects are caused independently of estrogen receptor and peroxisome proliferators-activated receptor.
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