The stress reaction and therapy for irritable bowel syndrome
| Project/Area Number |
22790609
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
MORISHITA Joe 東北大学, 医学(系)研究科(研究院), 教育研究支援者 (00375031)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 過敏性腸症候群 / 脳機能画像 / 脳腸相関 / 消化管運動機能 / 拡散テンソル画像 / ストレス / 消化管運動 |
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| Research Abstract |
There is no specific emotional task for patients with irritable bowel syndrome. Authors made the original task which provokes negative emotion in patients with irritable bowel syndrome. Irritable bowel syndrome-related pictures were presented to healthy controls and patients with irritable bowel syndrome. Healthy controls showed no changes in emotion, while patients with irritable bowel syndrome showed increase in negative emotion. Moreover, abdominal pain and urgency of defecation were exaggerated. This task is applicable for functional magnetic resonance imaging. In Voxel-based morphometry analysis, patients with irritable bowel syndrome showed significant increase of signal at premotor area and supplementary motor area. And in Diffusion tensor Imaging analysis, the area(38, -46, -2) represented significant increase of signal in patients with irritable bowel syndrome.
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Report
(5 results)
Research Products
(17 results)
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[Presentation] Neural Substrates of Decision Making in Irritable Bowel Syndrome2011
Author(s)
Emiko Aizawa, Takanori Kochiyama, Yasuhiro Sato, Joe Morishita, Atsushi Sekiguchi, Yuka Kotozaki, Michiko Kano, Motoyori Kanazawa, Motoaki Sugiura, Ryuta Kawashima, Hajime Mushiake, Shin Fukudo
Organizer
Digestive disease week Chicago
Place of Presentation
America
Related Report
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[Presentation] Increased Activation of ventromedial Prefrontal Cortex during Decision Making in Irritable Bowel Syndrome2011
Author(s)
Emiko Aizawa , Takanori Kochiyama, Yasuhiro Sato, Joe Morishita, Atsushi Sekiguchi, Yuka Kotozaki, Atsushi Miyazaki, Michiko Kano, Motoyori Kanazawa, Motoaki Sugiura, Ryuta Kawashima, Hajime Mushiake, and Shin Fukudo
Organizer
Neuro2011
Place of Presentation
Yokohama
Related Report
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