Effects of a high-fat or a high-sucrose diet on ultraviolet B irradiation-induced carcinogenesis and tumor growth in hairless mice.

• Project/Area Number: 22790619
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Ehime University
• Principal Investigator: SUMIYOSHI Maho 愛媛大学, 医学部, 研究員 (60444767)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 発癌 / 紫外線B波 / 肥満 / 耐糖能異常

Research Abstract

In this study, I examined the effects of a high-fat diet or a high-sucrose diet on ultraviolet(UV) B irradiation-induced carcinogenesis and tumor growth in melanin-possessing hairless mice. UVB irradiation-induced carcinogenesis and tumor growth in high-fat diet-fed mice were accelerated compared to those in control dietor high-sucrose diet-fed mice.