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Relationship between the nucleotide substitution rate of the hepatitis C virus and the effects of interferon therapy in children.

Research Project

Project/Area Number 22790622
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNagoya City University

Principal Investigator

ITO Koichi  名古屋市立大学, 大学院・医学研究科, 助教 (00444977)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
KeywordsHCV / 遺伝子 / NS5B / IFN / 母子感染
Research Abstract

Seven children infected by hepatitis C virus were treated with PEG-IFNα-2a at a dose of 90-180μg/kg s. c., once a week for 24-48 weeks. Six patients completed the treatment. One patient discontinued the treatment at 12 weeks. RVR was achieved in 2(29%) of the 7 patients. EVR was achieved in 7(100%) of the 7 patients. SVR was achieved in 6(86%) of the 7 patients. We isolated HCV-RNA from the sera of 7 children and analyzed the NS5b region. The nucleotide sequences in the NS5b region of HCV obtained from each of the children under treatment were identical to those of before treatment.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] Efficacy of pegylated interferon-α2a monotherapy in Japanese children with chronic hepatitis C2011

    • Author(s)
      Tomoyuki Tsunoda, Ayano Inui, Yuri Etani, Yuki Kiyohara, Tokio Sugiura, Koichi Ito, Reiko Miyazawa, Ikuo Nagata, Shinobu Ida, Tomoo Fujisawa
    • Journal Title

      Hepatology Research

      Volume: 41 Pages: 393-404

    • NAID

      10031144104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of pegylated interferon-a2α monotherapy in Japanese children with chronic hepatitis C2011

    • Author(s)
      Tomoyuki Tsunoda, Ayano Inui, Yuri Etani, Yuki Kiyohara, Tokio Sugiura, Koichi Ito, Reiko Miyazawa, Ikuo Nagata, Shinobu Ida, Tomoo Fujisawa
    • Journal Title

      Hepatology Research

      Volume: 41 Pages: 399-404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児の経静脈栄養に伴う胆汁うっ滞症2010

    • Author(s)
      伊藤孝一、杉浦時雄、後藤健之
    • Journal Title

      日本臨床領域別症候群シリーズ肝・胆道系症候群I肝臓編(上)

      Pages: 406-409

    • Related Report
      2011 Final Research Report
  • [Journal Article] 新生児の経静脈栄養に伴う胆汁うっ滞症2010

    • Author(s)
      伊藤孝一, 杉浦時雄, 後藤健之
    • Journal Title

      日本臨床領域別症候群シリーズ肝・胆道系症候群I肝臓編(上)

      Pages: 406-409

    • Related Report
      2010 Annual Research Report
  • [Presentation] PEG-IFN単独療法が有効であったC型肝炎ウイルス関連糸球体腎炎の一女児例2011

    • Author(s)
      杉浦時雄、遠藤剛、伊藤孝一
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳瘤・多彩な脳形成異常を合併した羊膜索症候群の1例2011

    • Author(s)
      粟屋梨沙、上田博子、後藤盾信、伊藤孝一、垣田博樹、杉浦時雄、長崎理香、加藤稲子、齋藤伸治、戸苅創
    • Organizer
      第56回日本未熟児新生児学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 著明な胆汁うっ滞を認めたZelleweger症候群の1例2011

    • Author(s)
      青山幸平、遠藤剛、伊藤孝一、杉浦時雄
    • Organizer
      第38回日本小児栄養消化器肝臓学会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] B型肝炎ウイルスキャリアにおけるプレコア、コアプロモータ領域の変異についての検討2011

    • Author(s)
      遠藤剛、伊藤孝一、杉浦時雄
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 急激な肝腫大を契機に発見された神経芽腫の一例2011

    • Author(s)
      鈴木敦詞、伊藤孝一、亀井美智、遠藤剛、杉浦時雄、伊藤康彦、斉藤伸治、佐藤陽子、近藤知史、鈴木達也、石倉聡
    • Organizer
      第28回日本小児肝臓研究会
    • Place of Presentation
      つくば
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 血清および尿中胆汁酸分析を行ったARC症候群の1例2011

    • Author(s)
      加藤丈典、山本宗美、浅野里美、佐橋剛、伊藤孝一、杉浦時雄
    • Organizer
      第47回日本周産期・新生児医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝線維症をきたした一過性骨髄異常増殖症(TAM)の一例2011

    • Author(s)
      鈴木敦詞、伊藤孝一, 垣田博樹、杉浦時雄、加藤稲子、戸苅創
    • Organizer
      第47回日本周産期・新生児医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生児・乳児期に高度の胆汁うっ滞を呈した先天性汎下垂体機能低下症の4例2011

    • Author(s)
      伊藤孝一、芦刈友加、加藤晋
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 胎児期よりフォローされたOEIS complexの12011

    • Author(s)
      大林勇輝、伊藤孝一、石田敦士、若月準、垣田博樹、杉浦時雄、水野晴夫、加藤稲子、水野健太郎、林祐太郎、佐藤陽子、近藤知史、鈴木達也、伊藤錦哉、和田郁雄、水谷栄太、後藤志信、鈴森伸宏、片野広之
    • Organizer
      第251回日本小児科学会東海地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 壊死性腸炎の病因と予防壊死性腸炎における交換輸血前後のサイトカインプロファイリング2010

    • Author(s)
      杉浦時雄、後藤健之、伊藤孝一、遠藤剛、竹中学、幸脇正典、小山典久、加藤稲子、戸苅創
    • Organizer
      第55回日本未熟児新生児学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-06
    • Related Report
      2011 Final Research Report
  • [Presentation] エンテカビルで治療したB型急性肝炎重症型の15歳男児例2010

    • Author(s)
      遠藤剛、伊藤孝一、杉浦時雄
    • Organizer
      第37回日本小児栄養消化器肝臓学会
    • Place of Presentation
      高松
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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