| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The cell type specific role of STAT3 was examined by using hepatocyte-specific STAT3 knockout mice and macrophage/neutrophil specific STAT3 knockout mice. Both knockout mice and control wild type mice were fed with methionine-choline deficient diet, which is a murine NASH model. We have shown activation of STAT3 in hepatocyte prevents steatosis by inhibiting SREBP1c activation. On the other hand, we have revealed activation of STAT3 in macrophage/neutrophil accelerates inflammation in the liver, while it prevents steatosis by STAT3 activation in hepatocytes.
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