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A study of liver regeneration and new treatment of hepatocellular carcinoma based on the understanding of hepatic stem/progenitor cells for building a base and development.

Research Project

Project/Area Number 22790634
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

TSUCHIYA Atsunori  新潟大学, 医歯学総合病院, 医員 (70464005)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肝再生 / 肝細胞癌 / SDF-1 / NCAM / soluble NCAM / 肝幹前駆細胞 / CXCR4 / 肝線維化 / HCC with progenitor features / Soluble NCAM / 140Kda NCAM / FGF
Research Abstract

In this study, we got the following two conclusions. One is that by using knockout mice of CXCR4, the receptor of SDF-1, we elucidated that SDF-1 that is produced by hepatic stem/progenitor cells is important during liver regeneration. The other is that we firstly detected hepatocellular carcinamo(HCC) with hepatic stem/progenitor cell marker NCAM and revealed that prognosis of these NCAM-positive HCC was very poor.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence2012

    • Author(s)
      Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y.
    • Journal Title

      J. Hepatol

      Volume: 56(2) Pages: 381-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM2011

    • Author(s)
      Tsuchiya A, Kamimura H, Tamura Y, Takamura M, Yamagiwa S, Suda T, Nomoto M, Aoyagi Y.
    • Journal Title

      Cancer Lett

      Volume: 309(1) Pages: 95-103

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM2011

    • Author(s)
      Tsuchiya A
    • Journal Title

      Cancer Lett.

      Volume: 309 Issue: 1 Pages: 95-103

    • DOI

      10.1016/j.canlet.2011.05.021

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice

    • Author(s)
      Tsuchiya A, Imai M, Kamimura H, Takamura M, Yamagiwa S, Sugiyama T, Nomoto M, Heike T, Nagasawa T, Nakahata T, Aoyagi Y
    • Journal Title

      Dig Dis Sci

      Volume: (in print)

    • Related Report
      2011 Final Research Report
  • [Presentation] 肝幹前駆細胞マーカーNCAMを用いたHCC with progenitor cell featuresの血清診断及び治療への応用の可能性2010

    • Author(s)
      土屋淳紀、野本実、青柳豊
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝幹前駆細胞マーカーNCAMを用いたHCC with progenitor cell featuresの血清診断および治療への応用の可能性2010

    • Author(s)
      土屋淳紀
    • Organizer
      JDDW 2010
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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