A study of liver regeneration and new treatment of hepatocellular carcinoma based on the understanding of hepatic stem/progenitor cells for building a base and development.

• Project/Area Number: 22790634
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Niigata University
• Principal Investigator: TSUCHIYA Atsunori 新潟大学, 医歯学総合病院, 医員 (70464005)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肝再生 / 肝細胞癌 / SDF-1 / NCAM / soluble NCAM / 肝幹前駆細胞 / CXCR4 / 肝線維化 / HCC with progenitor features / Soluble NCAM / 140Kda NCAM / FGF

Research Abstract

In this study, we got the following two conclusions. One is that by using knockout mice of CXCR4, the receptor of SDF-1, we elucidated that SDF-1 that is produced by hepatic stem/progenitor cells is important during liver regeneration. The other is that we firstly detected hepatocellular carcinamo(HCC) with hepatic stem/progenitor cell marker NCAM and revealed that prognosis of these NCAM-positive HCC was very poor.

Research Products

• [Journal Article] Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence (2012)
  • Author(s): Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y.
  • Journal Title: J. Hepatol Volume: 56(2) Pages: 381-8
• [Journal Article] Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM (2011)
  • Author(s): Tsuchiya A, Kamimura H, Tamura Y, Takamura M, Yamagiwa S, Suda T, Nomoto M, Aoyagi Y.
  • Journal Title: Cancer Lett Volume: 309(1) Pages: 95-103
• [Journal Article] Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM (2011)
  • Author(s): Tsuchiya A
  • Journal Title: Cancer Lett. Volume: 309 Issue: 1 Pages: 95-103
  • DOI: 10.1016/j.canlet.2011.05.021
  • Peer Reviewed
• [Journal Article] Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice
  • Author(s): Tsuchiya A, Imai M, Kamimura H, Takamura M, Yamagiwa S, Sugiyama T, Nomoto M, Heike T, Nagasawa T, Nakahata T, Aoyagi Y
  • Journal Title: Dig Dis Sci Volume: (in print)
• [Presentation] 肝幹前駆細胞マーカーNCAMを用いたHCC with progenitor cell featuresの血清診断及び治療への応用の可能性 (2010)
  • Author(s): 土屋淳紀、野本実、青柳豊
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 肝幹前駆細胞マーカーNCAMを用いたHCC with progenitor cell featuresの血清診断および治療への応用の可能性 (2010)
  • Author(s): 土屋淳紀
  • Organizer: JDDW 2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14