Analysis of the relationship between IL28B SNP and HCV genome

• Project/Area Number: 22790646
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Hiroshima University
• Principal Investigator: ABE Hiromi 広島大学, 大学院・医歯薬学総合研究科, 特任助教 (70572329)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝臓学 / ヒトゲノム / ウイルス / ヒト肝細胞キメラマウス / ゲノム / 肝炎ウイルス

Research Abstract

The current standard treatment for patients chronically infected with HCV is the combination of peg-interferon(PEG-IFN) and ribavirin(RBV). It has been reported that genetic variations within IL28B gene are associated with the effect of the PEG-IFN and RBV combination therapy. In this study, we investigated the expression levels of interferon related genes in the liver using liver biopsy from HCV patients before the treatment. We reported that the expression levels of anti-viral genes are lower, but those of negative regulator in IFN signaling are higher in favorable IL28B genotype patients.

Research Products

• [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronichepatitis 1 C patients (2012)
  • Author(s): Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
  • Journal Title: J Gastroenterol. In press
• [Journal Article] Severe Necroinflammatory Reaction Caused by Natural Killer By Fas/ FasLInteraction and Dendritic Cells in Human Hepatocyte Chimeric Mouse (2012)
  • Author(s): Okazaki A, Hiraga N, Imamura M, Hayes CN, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, TatenoC, Yoshizato K, Ohdan H, Chayama K
  • Journal Title: Hepatology. In press
• [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-α-2bplus ribavirin therapy in chronichepatitis C virus infection (2012)
  • Author(s): Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, KamataniN, Nakamura Y, Chayama K
  • Journal Title: J Viral Hepat Volume: 19 Pages: 126-133
• [Journal Article] Toward the establishment of aprediction system for the personalized treatment of chronic hepatitis C (2012)
  • Author(s): Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Infect Dis Volume: 205 Pages: 204-210
• [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis 1 C patients (2012)
  • Author(s): Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
  • Journal Title: J Gastroenterol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse (2012)
  • Author(s): Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
  • Journal Title: Hepatology Volume: (in press) Issue: 2 Pages: 25651-25651
  • DOI: 10.1002/hep.25651
  • Peer Reviewed
• [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection (2012)
  • Author(s): Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Viral Hepat Volume: 19 Issue: 2 Pages: 126-133
  • DOI: 10.1111/j.1365-2893.2011.01516.x
  • Peer Reviewed
• [Journal Article] Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C (2012)
  • Author(s): Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Infect Dis Volume: 205 Pages: 204-210
  • Peer Reviewed
• [Journal Article] Hepatitis C virus in fection suppresses the interferon response in the liver of thehuman hepatocyte chimeric mouse (2011)
  • Author(s): Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, HayesCN, Miya F, Tsunoda T, Chayama K
  • Journal Title: PLoS One Volume: 6
• [Journal Article] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population (2011)
  • Author(s): Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
  • Journal Title: Hum Mol Genet Volume: 20 Pages: 3884-3892
• [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama KMiki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: Nat Genet Volume: 43 Pages: 797-800
• [Journal Article] Effects of hepatitis B virus in fection on the interferon response in immunodeficient human hepatocyte chimeric mice (2011)
  • Author(s): Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, HayesCN, Chayama K
  • Journal Title: J Infect Dis Volume: 204 Pages: 224-228
• [Journal Article] IL28B But Not ITPA Polymorphism Is Predictive of Response to Pegylated Interferon, Ribavirin, and Telaprevir Triple Therapy in Patients With Genotype 1 Hepatitis C (2011)
  • Author(s): Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, Nakamura Y, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
  • Journal Title: J Infect Dis Volume: 204 Pages: 84-93
• [Journal Article] Rapid emergence of telaprevir resistant hepatitis C virus strain fromwild type clone in vivo (2011)
  • Author(s): Hiraga N, Imamura M, Abe H, NelsonHayes C, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, MatsuiH, Kanai A, Inaba T, Tanaka S, Chayama K
  • Journal Title: Hepatology Volume: 54 Pages: 781-788
• [Journal Article] Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis Cvirus (2011)
  • Author(s): Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
  • Journal Title: Hepatology Volume: 54 Pages: 764-771
• [Journal Article] Inverse association of IL28 Bgenotype and liver mRNA expression of genes promoting or suppressing antiviralstate (2011)
  • Author(s): Abe H, Hayes C. N, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med. Virol Volume: 83 Pages: 1597-1607
• [Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-inducedanemia and effect of peg-interferon plusribavirin therapy (2011)
  • Author(s): Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med. Virol Volume: 83 Pages: 1048-1057
• [Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infectedwith hepatitis C virus genotype 1b (2011)
  • Author(s): Hashimoto Y, Ochi H, Abe H, HayashidaY, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson HayesC, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Med. Virol Volume: 83 Pages: 981-988
• [Journal Article] IL-28B predicts response to chronichepatitis C therapy-fine-mapping andreplication study in Asian populations (2011)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, KuboM, Tsunoda T, Kumada H, Nakamura Y, Hayes CN, Chayama K
  • Journal Title: J Gen Virol Volume: 92 Pages: 1091-1081
• [Journal Article] Animal model for study of human hepatitis viruses (2011)
  • Author(s): Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 13-18
• [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome canpredict virological decrease withpegylated interferon plus ribavirin therapy (2011)
  • Author(s): Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
  • Journal Title: Antivir Ther Volume: 15 Pages: 1087-1097
• [Journal Article] ME3738 enhances the effect of interferon and inhibits hepatitis C virusreplication both in vitro and in vivo (2011)
  • Author(s): Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
  • Journal Title: J Hepatol Volume: 55 Pages: 11-18
• [Journal Article] Elimination of hepatitis C virus byshort term NS3-4A and NS5B inhibitorcombination the rapy in human hepatocyte chimeric mice (2011)
  • Author(s): Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S, Chayama K
  • Journal Title: J Hepatol Volume: 54 Pages: 872-878
• [Journal Article] IL28 variation affects expression of interferon stimulated genes andpeg-interferon and ribavirin therapy (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Pages: 1094-1101
• [Journal Article] A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients (2011)
  • Author(s): Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 54 Pages: 629-639
• [Journal Article] Predictive value of the IL28 Bpolymorphism on the effect of interferontherapy in chronic hepatitis C patientswith genotypes 2a and 2b (2011)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K
  • Journal Title: J Hepatol Volume: 54 Pages: 408-414
• [Journal Article] HCV substitutions and IL28B polymor phisms on out come of peg-interferon plus ribavirin combination the rapy (2011)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: Gut Volume: 60 Pages: 261-267
• [Journal Article] Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse (2011)
  • Author(s): Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, Hayes CN, Miya F, Tsunoda T, Chayama K
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Eisk Locus in a Japanese Population (2011)
  • Author(s): Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
  • Journal Title: Hum Mol Genet Volume: 20 Pages: 3884-3892
  • Peer Reviewed
• [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers (2011)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: Nat Genet Volume: 43 Issue: 8 Pages: 797-800
  • DOI: 10.1038/ng.876
  • Peer Reviewed
• [Journal Article] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice (2011)
  • Author(s): Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
  • Journal Title: J Infect Dis Volume: 204 Pages: 224-228
  • Peer Reviewed
• [Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo (2011)
  • Author(s): Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 781-788
  • DOI: 10.1002/hep.24460
  • Peer Reviewed
• [Journal Article] Impact of viral aminoacid substitutions and hostinterleukin-28b polymorphism on replication and susceptibility tointerferon of hepatitis C virus (2011)
  • Author(s): Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 764-711
  • DOI: 10.1002/hep.24453
  • Peer Reviewed
• [Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state (2011)
  • Author(s): Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 9 Pages: 1597-1607
  • DOI: 10.1002/jmv.22158
  • Peer Reviewed
• [Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy (2011)
  • Author(s): Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 1048-1057
  • DOI: 10.1002/jmv.22069
  • Peer Reviewed
• [Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b (2011)
  • Author(s): Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
  • Journal Title: J Med Virol Volume: 83 Issue: 6 Pages: 981-988
  • DOI: 10.1002/jmv.22028
  • Peer Reviewed
• [Journal Article] IL-28B predicts response to chronic hepatitis C therapy-fine-mapping and replication study in Asian populations (2011)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, Hayes CN, Chayama K
  • Journal Title: J Gen Virol Volume: 92 Pages: 1071-1081
  • Peer Reviewed
• [Journal Article] Animal model for study of human hepatitis viruses. (2011)
  • Author(s): Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 26(1) Pages: 13-18
  • Peer Reviewed
• [Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. (2011)
  • Author(s): Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
  • Journal Title: Gut. Volume: 60(2) Pages: 261-267
  • Peer Reviewed
• [Journal Article] ITPA polymorphism affectsribavirin-induced anemia and outcomes of the rapy-a genome-wide study ofJapanese HCV virus patients (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, HayesCN, Kumada H, Nakamura Y, Chayama K
  • Journal Title: Gastroenterology Volume: 139 Pages: 1190-1197
• [Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitisC virus patients (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K
  • Journal Title: J Hepatol Volume: 53 Pages: 439-443
• [Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovircombination therapy in patients withlamivudine-resistant chronic hepatitis (2010)
  • Author(s): B. Mitsui F, Tsuge M, Kimura T, KitamuraS, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 3205-3211
• [Journal Article] Differential effects of interferon and lamivudine on serum HBV RNAinhibition in patients with chronichepatitisB (2010)
  • Author(s): Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, HuJT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH
  • Journal Title: Antivir Ther Volume: 15 Pages: 177-184
• [Journal Article] HBx protein is in dispensable for development of viraemia in humanhepatocyte chimeric mice (2010)
  • Author(s): Tsuge M, Hiraga N, Akiyama R, TanakaS, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, TakahashiS, Hayes CN, Chayama K
  • Journal Title: J Gen Virol Volume: 91 Pages: 1854-1864
• [Journal Article] G to A hypermutation of TT virus (2010)
  • Author(s): Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K.
• [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy. (2010)
  • Author(s): Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K.
  • Journal Title: Antivir Ther. Volume: 15(8) Pages: 1087-1097
  • Peer Reviewed
• [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. (2010)
  • Author(s): Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
  • Journal Title: J Hepatol. Volume: 54(3) Pages: 408-414
  • Peer Reviewed
• [Journal Article] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients. (2010)
  • Author(s): Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K.
  • Journal Title: Gastroenterology Volume: 139(4) Pages: 1190-1197
  • Peer Reviewed
• [Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. (2010)
  • Author(s): Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K
  • Journal Title: J Hepatol. Volume: 53(3) Pages: 439-443
  • NAID: 120002577227
  • Peer Reviewed
• [Presentation] Analysis of expression levels of interferon stimulated genes by IL28B genotypes in human hepatocyte chimeric mice during interferon alpha treatment against hepatitis C virus infection (2011)
  • Author(s): Hiromi Abe, Nobuhiko Hiraga, Michio Imamura, C.Nelson Hayes, Daiki Miki, Masataka Tsuge, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama
  • Organizer: AASLD Annual Meeting
  • Place of Presentation: アメリカ(サンフランシスコ)
  • Year and Date: 2011-11-02
• [Presentation] IL28Bの遺伝子多型とその他の調節機構による抗ウイルス遺伝子と抑制性遺伝子の間の反対方向の調節 (2011)
  • Author(s): 阿部弘美, C.Nelson Hayes, 越智秀典, 三木大樹, 柘植雅貴, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-03
• [Presentation] IL28Bの遺伝子多型とその他の調節機構による抗ウイルス遺伝子と抑制性遺伝子の間の反対方向の調節 (2011)
  • Author(s): 阿部弘美
  • Organizer: 日本肝臓学会
  • Place of Presentation: 東京
• [Presentation] Pretreatment of hepatomacell lines with IL28B delaysinterferon-induced ISG expression, whereas pretreatment with neutralizingan tibodies against IL28B reduces ISG expression levels (2011)
  • Author(s): Abe H. et al
  • Organizer: 46th Annual Meeting ofEuropean Association for the Study of theLiver(EASL)
  • Place of Presentation: Berlin, Germany
• [Presentation] Reciprocal control of interferon stimulated gene mRNAs between positive anti-viral effecter and negative regulator by IL28B gene polymorphism and by another regulatory mechanism. (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, C.Nelson Hayes, 茶山一彰
  • Organizer: 2010 AASLD Annual Meeting
  • Place of Presentation: アメリカ(ボストン)
  • Year and Date: 2010-11-02
• [Presentation] Different regulation of expression levels of interferon stimulated genes (ISGs) in peripheral blood versus liver by IL28B polymorphisms and influence on biochemical data and inflammation of the liver. (2010)
  • Author(s): 阿部弘美, C.Nelson Hayes, 越智秀典, 三木大樹, 柘植雅貴, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 2010 HCV 2010 17^<th> International Meeting on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-11
• [Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] IL28の多型とC型慢性肝炎の炎症、線維化、γGTPとの関連 (2010)
  • Author(s): 阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-28
• [Presentation] Reciprocal control of interferon stimulated gene mRNAs betweenpositive anti-viral effecter and negativeregulator by IL28B gene polymorphism andby another regulatory mechanism (2010)
  • Author(s): Abe H. et al
  • Organizer: AASLDAnnual Meeting
  • Place of Presentation: Boston, USA
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/naika1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/nbard/biom/saisei.htm
• [Remarks]
  • URL: http://www.src.riken.go.jp/group/liver/index.html