Comprehensive analysis of the tyrosine metabolic enzymes included in the candidates of liver protection pathways

• Project/Area Number: 22790648
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: The University of Tokushima
• Principal Investigator: HIYOSHI Mineyoshi 徳島大学, 疾患酵素学研究センター, 学術研究員 (30363162)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝傷害 / チロシン代謝 / D-ドーパクロムトートメラーゼ / カテコール-0-メチル基転移酵素 / カテコール-O-メチルトランスフェラーゼ / プロテオミクス

Research Abstract

In the damaged rat liver, soluble catechol-0-methyltransferase(COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. To evaluate the association between COMT genotypes and liver function, we used data from the Japan Multi-Institutional Collaborative Cohort(J-MICC) Study. In this study, we revealed that a COMT polymorphism(rs4680 : Val158Met(G/ A)) affected liver function.

Research Products

• [Journal Article] Intrauterine sensitization of allergen-specific IgE analyzed by a highly sensitive new allergen microarray (2012)
  • Author(s): Kamemura, N., Tada, H., Shimojo, N., Morita, Y., Kohno, Y., Ichioka, T., Suzuki, K., Kubota, K., Hiyoshi, M., and Kido, H
  • Journal Title: The Journal of Allergy and Clinical Immunology Volume: (in press) Issue: 1 Pages: 113-121.e2
  • DOI: 10.1016/j.jaci.2012.02.023
  • Peer Reviewed
• [Journal Article] Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population (2012)
  • Author(s): Uemura, H., Hiyoshi, M., Arisawa, K., Yamaguchi, M., Naito, M., Kawai, S., Hamajima, N., Matsuo, K., Taguchi, N., Takashima, N., Suzuki, S., Hirasada, K., Mikami, H., Ohnaka, K., Yoshikawa, A., Kubo M., and Tanaka, H
  • Journal Title: Maturitas Volume: 71(4) Issue: 4 Pages: 369-375
  • DOI: 10.1016/j.maturitas.2011.12.021
  • Peer Reviewed
• [Journal Article] Association between the catechol-O-methyltransferase (rs4680 : Vall58Met) polymorphism and serum alanine amine aminotrsferase activity. (2012)
  • Author(s): Hiyoshi M, et al.
  • Journal Title: Gene Volume: 496 Issue: 2 Pages: 97-102
  • DOI: 10.1016/j.gene.2012.01.015
  • Peer Reviewed
• [Journal Article] Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/ PCDFs/ dioxin-like PCBs in blood from the Japanese population (2011)
  • Author(s): Kitayama, A., Arisawa, K., Uemura, H., Hiyoshi, M., Takami, H., Sawachika, F., Yamaguchi, M., Nakamoto, M., Hasegawa, M., Tanto, M., Shima, M., Sumiyoshi, Y., Morinaga, K., Kodama, K., Suzuki, T. I., Nagai, M., and Satoh, H
  • Journal Title: International Archives of Occupational and Environmental Health Volume: 84(8) Issue: 8 Pages: 927-935
  • DOI: 10.1007/s00420-011-0618-7
  • Peer Reviewed
• [Journal Article] Allergen diagnosis microarray with high-density immobilization capacity using diamond-like carbon-coated chips for profiling allergen-specific IgE and other immunoglobulins (2011)
  • Author(s): Suzuki, K., Hiyoshi, M., Tada, H., Bando, M., Ichioka, T., Kamemura, N., and Kido, H
  • Journal Title: Analytica chimica acta Volume: 706(2) Issue: 2 Pages: 321-327
  • DOI: 10.1016/j.aca.2011.08.034
  • Peer Reviewed
• [Journal Article] Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex (2011)
  • Author(s): Takeda S., et al
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 410 Issue: 1 Pages: 29-33
  • DOI: 10.1016/j.bbrc.2011.05.099
  • Peer Reviewed
• [Journal Article] Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2011)
  • Author(s): K. Wakai, N. Hamajima, R. Okada, M. Naito, E. Morita, A. Hishida, S. Kawai, K. Nishio, G. Yin, Y. Asai, K. Matsuo, S. Hosono, H. Ito, M. Watanabe, T. Kawase, T. Suzuki, K. Tajima, K. Tanaka, Y. Higaki, M. Hara, T. Imaizumi, N. Taguchi, K. Nakamura, H. Nanri, T. Sakamoto, M. Horita, K. Shinchi, et al(49 others)
  • Journal Title: Journal of Epidemiology Volume: 21 Issue: 3 Pages: 223-235
  • DOI: 10.2188/jea.JE20100139
  • NAID: 10030212853
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Dietary patterns and blood levels of PCDDs, PCDFs, and dioxin-like PCBs in 1656 Japanese individuals (2011)
  • Author(s): Arisawa, K., Uemura, H., Hiyoshi, M., Kitayama, A., Takami, H., Sawachika, F., Nishioka, Y., Hasegawa, M., Tanto, M., Satoh, H., Shima, M., Sumiyoshi, Y., Morinaga, K., Kodama, K., Suzuki, T. I., and Nagai, M
  • Journal Title: Chemosphere Volume: 82(5) Issue: 5 Pages: 656-662
  • DOI: 10.1016/j.chemosphere.2010.11.008
  • Peer Reviewed
• [Journal Article] Dietary patterns and blood levels of PCDDs, PCDFs, and dioxin-like PCBs in 1656 Japanese individuals. (2011)
  • Author(s): Arisawa K, et al.
  • Journal Title: Chemosphere Volume: 82 Pages: 656-662
  • Peer Reviewed
• [Journal Article] Congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers in the general Japanese population (2010)
  • Author(s): Uemura, H., Arisawa, K., Hiyoshi, M., Dakeshita, S., Kitayama, A., Takami, H., Sawachika, F., Yamaguchi, M., and Sasai S
  • Journal Title: Chemosphere Volume: 79(7) Issue: 7 Pages: 706-712
  • DOI: 10.1016/j.chemosphere.2010.02.050
  • Peer Reviewed
• [Journal Article] Congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers in the general Japanese population. (2010)
  • Author(s): Uemura H, et al.
  • Journal Title: Chemosphere Volume: 79 Pages: 706-712
  • Peer Reviewed
• [Presentation] 血管脈派伝播速度と体格指標との関係についての検討J-MICC Study徳島地区のデータより (2011)
  • Author(s): 上村浩一、日吉峰麗、山口美輪、中本真理子、武田英雄、高見栄喜、北山淳、澤近房和、十田朋也、有澤孝吉
  • Organizer: 第56回四国公衆衛生学会・研究発表会
  • Place of Presentation: アルファあなぶきホール(高松市)
  • Year and Date: 2011-02-04
• [Presentation] J-MICC Study Group. ADIPOQおよびADRB3遺伝子多型が自然閉経年齢に及ぼす影響についての検討 (2011)
  • Author(s): 上村浩一、日吉峰麗、山口美輪、中本真理子、武田英雄、嵩下賢、高見栄喜、北山淳、澤近房和、十田朋也、有澤孝吉
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道立道民活動センターかでる2. 7(札幌市)
  • Year and Date: 2011-01-22
• [Presentation] インフルエンザ感染の重症化促進因子、血管内皮細胞の細胞間接着障害に与えるウイルス感染と解熱剤の障害促進効果の解析 (2011)
  • Author(s): 日吉峰麗、矢野仁康、木戸博
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] J-MICC Study Group. COMT遺伝子多型と肝機能-動物実験と日本多施設共同コーホート研究- (2011)
  • Author(s): 日吉峰麗、上村浩一、山口美輪、中本真理子、武田英雄、高見栄喜、有澤孝吉
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学(品川区)
• [Presentation] ADIPOQおよびADRB3遺伝子多型が自然閉経年齢に及ぼす影響についての検討 (2011)
  • Author(s): 上村浩一, 他
  • Organizer: 第21回日本疫学会・学術総会
  • Place of Presentation: 北海道立道民活動センター(札幌市)
• [Presentation] COMT遺伝子多型と肝機能-動物実験と日本多施設共同コーホート研究- (2011)
  • Author(s): 日吉峰麗, 他
  • Organizer: 第81回日本衛生学会・学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス(東京都品川区)
• [Presentation] 日本の一般住民におけるポリ臭素化ジフェニルエーテルの蓄積状況についての検討 (2010)
  • Author(s): 上村浩一、日吉峰麗、北山淳、高見栄喜、澤近房和、山口美輪、嵩下賢、有澤孝吉
  • Organizer: 第80回日本衛生学会・学術総会
  • Place of Presentation: 仙台国際センター(仙台市)