Analysis of the transcriptional control mechanism which regulates generation, development and disease of cardiovascular system

• Project/Area Number: 22790689
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: NISHIMURA Go 東京大学, 医学部・附属病院, 助教 (20422305)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 転写因子SIP1 / TGFβ / 大動脈弁 / 分子血管病態学 / TGF / BMP

Research Abstract

Mutations in transcription factor SIP1(Smad interacting protein 1) cause cardiac malformation in human. Cardiovascular specific conditional knockout mice of SIP1 have thick aortic valve leaflets. Immunohistochemical staining showed that collagen and proteoglycan accumulate in the aortic valve leaflets of SIP1 knockout mice. The study in cultured cells revealed that SIP1 regulates the expression of genes which are relevant to the proteoglycan metabolism. This finding would throw some light on figure out the mechanism causing congenital heart disease.