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Development of the molecular basis of novel therapeutic strategy for heart failure by the control of cardiac remodeling

Research Project

Project/Area Number 22790693
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

YOSHIKAWA Noritada  東京大学, 医科学研究所, 助教 (70396878)

Co-Investigator(Renkei-kenkyūsha) TANAKA Hirotoshi  東京大学, 医科学研究所, 准教授 (00171794)
SHIMIZU Noriaki  東京大学, 医科学研究所, 特任研究員 (30396890)
SANO Motoaki  慶應義塾大学, 医学部, 講師 (30265798)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心肥大 / 心臓リモデリング / 心不全 / HEXIM1 / 転写伸長反応 / P-TEFb / RNAポリメラーゼII / 右心肥大 / 肺高血圧症 / 心筋リモデリング
Research Abstract

[Objectives] Because HEXIM is the only molecule to inhibit P-TEFb, which is the key molecule for development of cardiac hypertrophy, we speculate that HEXIM1 may be a candidate for preventing cardiac hypertrophy/remodeling.[ Methods and Results] Using adenovirus mediated gene delivery to the cultured cardiac myocytes and a new transgenic mouse model with conditional myocardial overexpression of HEXIM1, we confirmed that overexpression of HEXIM1 in the cardiac myocytes prevents cardiac myocyte hypertrophy both in vitro and in vivo.[ Conclusion] HEXIM1 may be a candidate for preventing cardiac hypertrophy/remodeling.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle2011

    • Author(s)
      S himizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H
    • Journal Title

      Cell Metab

      Volume: 13 Issue: 2 Pages: 170-182

    • DOI

      10.1016/j.cmet.2011.01.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺動脈性肺高血圧症PAHに対する新規分子標的薬開発へ向けた基盤研究2011

    • Author(s)
      吉川賢忠
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺動脈性肺高血圧症PAHに対する新規分子標的薬開発へ向けた基盤研究2011

    • Author(s)
      吉川賢忠
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸市(招待講演)
    • Year and Date
      2011-07-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膠原病性肺高血圧症に対する新規分子標的薬開発へ向けた基礎的検討2010

    • Author(s)
      吉川賢忠
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 膠原病性肺高血圧症に対する新規分子標的薬開発へ向けた基礎的検討2010

    • Author(s)
      吉川賢忠、森本幾夫、田中廣壽, 他
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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