Analysis of type 5 adenylyl cyclase role for the production of active oxygen and its clinical application for the treatment of heart failure
Project/Area Number |
22790719
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Yokohama City University |
Principal Investigator |
BAI Yunzhe 横浜市立大学, 医学研究科, 共同研究員 (50571147)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 医歯薬学 / シグナル伝達 / 循環器高血圧 / サイクリックAMP / 心不全 / 遺伝子改変マウス / 循環器・高血圧 |
Research Abstract |
Type 5 adenylyl cyclase (AC5)is a major cardiac isoform and AC5 null mice show the resistance to oxidative stress and heart failure. Recent studies have shown that cAMP can activate Epac1, exchange protein directly activated by cAMP, as well. However, its role in the pathogenesis of heart failure remains unknown. In order to examine the role of Epac1 in the heart, we have generated the cardiac-specific type 5 adenylyl cyclase, a major cardiac AC isoform, transgenic mice (AC5TG) and Epac1-deficient AC5TG (AC5TG-EpacKO) and demonstrated that cAMP-Epac1 pathway plays an important role for the development of heart failure through the activation of cAMP-PKA pathway, suggesting that this pathway may be a new target for the treatment of heart failure.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight2012
Author(s)
Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S
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Journal Title
J Pharmacol Sci
Volume: 119:381-189
NAID
Related Report
Peer Reviewed
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[Journal Article] Pharmacological Stimulation of Type 5 Adenylyl Cyclase Satbilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight2012
Author(s)
Yunzhe Bai, Takashi Tsunematsu, Qibin Jiao, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Meihua Jin, Wenqian Cai, Hui-Ling Jin, Takayuki Fujita, Yasuhiro Ichikawa, Kenji Suita et al.
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Journal Title
J Pharamacol Sci
Volume: 119
Pages: 381-389
Related Report
Peer Reviewed
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[Journal Article] Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y2011
Author(s)
Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y
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Journal Title
J Biol Chem
Volume: 286
Pages: 17766-17776
Related Report
Peer Reviewed
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[Presentation] Disruption of Epac1 decreases phosphorylation of phospholamban and protects the heart against stress2012
Author(s)
Okumura S, Jing M, Ohnuki Y, Namekata I, Kurotani R, Fujita T, Jin H-L, Cai W, Bai Y, Suita K, Tsunematsu T et al
Organizer
merican Heart Association Scientific Scission 2012
Place of Presentation
Los Angeles, California, USA
Year and Date
2012-11-06
Related Report
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[Presentation] Disruption of Epac1 Decreases Phosphorylation of Phospholamban and Protects the Heart Against Stress
Author(s)
Satoshi Okumura, Meihua Jing, Yoshiki Ohnuki, Iyuki Namekata, Reiko Kurotani, Takayuki Fujita, Hui-Ling Jin, Wengian Cai, Yunzhe Bai, Kenji Suita, Takashi Tsunematsu et al.
Organizer
American Heart Association Scientific Scission 2012
Place of Presentation
Los Angeles, California, USA
Related Report
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