Physiological roles of(pro) renin receptor in vascular smooth muscle cells
| Project/Area Number |
22790729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
MITO Asako 慶應義塾大学, 医学部, 助教 (20468474)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | (プロ)レニン受容体 / 血管平滑筋細胞 / 線維化 / V-ATPase / 繊維化 |
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| Research Abstract |
This study is performed to examine the roles of(pro) renin receptor in the development and physiology of vascular smooth muscle cells. The smooth muscle cell-specific Atp6ap2 conditional knockout(CKO) mice were generated by mating female Atp6ap2-floxed mice with male mice that expressed the Cre recombinase under the control of the myosin heavy chain(Myh-11) promoter. Histological examination revealed that the CKO mice exhibited the decreased number of vascular smooth muscle cells and increased number of fibroblasts in the aorta due to vascular muscle cell death. Our researches revealed that the(P) RR/ATP6AP2 physiologically plays an essential role in the cell survival of mouse vascular smooth muscle cells through contributing to assembly and function of vacuolar H^+-ATPase.
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Report
(3 results)
Research Products
(11 results)
