Analysis of Nucleotide sugar: Association with pathogenesis of COPD in Leukocyte
| Project/Area Number |
22790755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The Institute of Physical and Chemical Research (2011-2012)
Osaka University (2010) |
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Principal Investigator |
TAKAMIYA Rina 独立行政法人理化学研究所, 糖鎖認識研究チーム, 基幹研究所研究員 (70365419)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗炎症性脂質メディエーター / 慢性閉塞性肺疾患 / マクロファージ / 活性酸素種 / 脂質メディエーター / COPD / SOD1 / 酸化ストレス / 糖鎖 / マクロフィージ / SOD-1 |
|---|
| Research Abstract |
It is well known that cigarette smoke (CS) induces disability of macrophage function by oxidative stress. We indicated that CS induced bisecting GlcNAc modification in macrophage. Furthermore, pretreatment of macrophages with a pro-resolving mediator, Resolvin E1(RvE1) restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 have new potential therapeutic applications in COPD.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma2013
Author(s)
Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, Takamiya R, Takihara T, Tomomatsu K, Suzuki Y, Oguma T, Sayama K, Arai H, Betsuyaku T, Arita M, Asano K.
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Journal Title
J Allergy Clin Immunol
Volume: 131
Issue: 2
Pages: 353-360
DOI
Related Report
Peer Reviewed
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[Journal Article] Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma2012
Author(s)
Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, Takamiya R, Takihara T, Tomomatsu K, Suzuki Y, Ogum, Sayama K, Arai H, Betsuyaku T, Arita M, Asano K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Annexin V decreases PS-1 mediated macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice2012
Author(s)
Yoshida S, Minematsu N, Chubachi S, Nakamura H, Miyazaki M, Tsuduki K, Takahashi S, Miyasho T, Iwabuchi T, Takamiya R, Tateno H, Mouded M, Shapiro SD, Asano K, Betsuyaku T
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 303
Related Report
Peer Reviewed
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[Journal Article] Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice2011
Author(s)
Kamata H, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Shinoda H, Kimizuka Y, Fujiwara H, Ishii M, Hasegawa N, Takamiya R, Fujishima S, Takano H, Ishizaka A,
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Journal Title
Exp Biol Med (Maywood)
Volume: 236
Pages: 315-324
Related Report
Peer Reviewed
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