Anti-EGFR antibody conjugated gold liposome for molecular imaging and therapy on NSCLC cells

• Project/Area Number: 22790770
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tokyo Medical University
• Principal Investigator: YOKOYAMA Tomohisa 東京医科大学, 医学部, 講師 (40408240)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 非小細胞肺癌 / ナノ粒子 / DDS(drug delivery system) / オートファジー / DDS / 金ナノ粒子 / Drug Delivery System / 抗EGFR抗体 / エンドサイトーシス / DDS (Drug Delivery System)

Research Abstract

In the present study, we investigated in vitro effect of these liposomes on EGFR-expressing/-null NSCLC cells. Our findings demonstrated that EGFR-targeted liposome is a promising agent for therapy and molecular imaging of NSCLC

Research Products

• [Presentation] EGFR-targeted gold liposome for molecular imaging and therapy on NSCLC cells (2012)
  • Author(s): 横山智央
  • Organizer: 2012 AACR Annual Meeting
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2012-04-02
• [Presentation] EGFR-targeted gold liposome for molecular imaging and therapy on NSCLC cells. (2012)
  • Author(s): Yokoyama T, Osato Y, Miyazawa K, Hayabe H, Miyasato A, Nomura M, Gotoh N, Itoi T, Tauchi T, Ikeda N, Ohyashiki K
  • Organizer: AACR 103th Annual meeting 2012
  • Place of Presentation: Chicago USA
• [Presentation] Anti-EGFR antibody conjugated gold liposome for molecular imaging and therapy on NSCLC cells (2011)
  • Author(s): Yokoyama T, Miyazawa K, Nomura M, Gotoh N, Ohyashiki K
  • Organizer: 第49回日本癌学会学術集会
  • Place of Presentation: 名古屋