Development of the new therapy for renal tubule regeneration by the acute kidney injury by regenerative medicine

• Project/Area Number: 22790793
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Kochi University
• Principal Investigator: OGATA Koji 高知大学, 医学部附属病院, 特任助教 (30527586)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 再生医療 / 尿中バイオマーカー / 尿細管細胞 / 急性腎障害 / 腎尿細管細胞 / 腎再生

Research Abstract

A possibility that HNF-1beta which is a transcription factor revealed to a kidney or liver was participating in the renal tubular cell reproduction at the time of the acute kidney injury after ischemia re-perfusion was able to be considered.Therefore, we did various researches which used the proximal tubular cell, and reported the result to American Journal of Physiology(303:F689-F699,2012) as a thesis, and announced also at the international society.

Research Products

• [Journal Article] Upregulation ofHNF-1β during experimental acutekidney injury plays a crucial role inrenal tubule regeneration (2012)
  • Author(s): Ogata K, ShimamuraY, HamadaK, HisaM, BunM, OkadaN, InoueK, TaniguchiY, Ishihara M, Kagawa T, Horino T,FujimotoS, Terada Y
  • Journal Title: AmericanJournal of Physiology Volume: 303
• [Journal Article] Aldosterone Stimulates NF-kB Activityand Transcription of ICAM-1 and CTGFin Rat Mesangial Cells via SGK(Serum and Glucocorticoid-inducible Protein Kinase)-1 (2012)
  • Author(s): Terada Y, Ueda S, Hamada K, ShimamuraY, Ogata K, Inoue K, Taniguchi Y,Kagawa T, Horino T, Takao T
  • Journal Title: Clinical and Experimental Nephrology Volume: 16 Pages: 81-88
• [Journal Article] Upregulation of HNF-1β during experimental acute kidney injury plays a crucial role in renal tubule regeneration. (2012)
  • Author(s): Ogata K,Inoue K,et al
  • Journal Title: 10.1152/ajprenal.00086 Volume: 303 Issue: 5 Pages: 689-699
  • DOI: 10.1152/ajprenal.00086.2012
  • Peer Reviewed
• [Journal Article] Possible involvement ofintracellular angiotensin IIreceptor in high-glucose-induceddamage in renal proximal tubular cells (2011)
  • Author(s): Takao T, Horino T, Kagawa T, MatsumotoR, Shimamura Y, Ogata K, Inoue K,Taniguchi Y, Taguchi T, Morita T,Terada Y
  • Journal Title: Journal of Nephrology Volume: 24(03) Pages: 218-224
• [Journal Article] 巣状糸球体硬化症-病因から治療まで- (2011)
  • Author(s): 緒方巧二, 濱田佳寿, 上田訓子, 島村芳子, 井上紘輔, 谷口義典, 香川亨, 寺田典生
  • Journal Title: 臨牀と研究 Volume: 88 Pages: 491-496
• [Journal Article] 炭酸脱水酵素阻害薬,浸透圧利尿薬,バソプレッシン拮抗薬(臨床医が知っておくべきこと,将来性を含めて) (2011)
  • Author(s): 緒方巧二, 島村芳子, 井上紘輔, 香川亨, 寺田典生
  • Journal Title: Modern Physician Volume: 31 Pages: 731-733
• [Journal Article] 多発性骨髄腫と腎障害 (2011)
  • Author(s): 緒方巧二, 上田訓子, 島村芳子, 井上紘輔, 香川亨, 寺田典生
  • Journal Title: 綜合臨牀 Volume: 60 Pages: 1421-1424
• [Journal Article] Cisplatin-induced macroautophagyoccurs prior to apoptosis in proximaltubules in vivo (2010)
  • Author(s): Inoue K,Kuwana H,Shimamura Y,OgataK,Taniguchi Y,Kagawa T,Horino T,Morita T, Mizushima N,Terada Y
  • Journal Title: Clinical andexperimental Nephrology Volume: 14 Pages: 112-122
• [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. (2010)
  • Author(s): Inoue K, Ogata K, Terada Y., et al.
  • Journal Title: Clinical and experimental Nephrology Volume: 14 Pages: 112-122
  • NAID: 10027228406
  • Peer Reviewed
• [Journal Article] AKI治療におけるstem cellの可能性 (2010)
  • Author(s): 寺田典生, 緒方巧二, 他
  • Journal Title: 腎と透析 Volume: 6 Pages: 381-381
• [Journal Article] 尿細管障害と回復のメカニズム (2010)
  • Author(s): 寺田典生, 緒方巧二, 他
  • Journal Title: 日本腎臓学会誌 Volume: 52 Pages: 558-561
  • NAID: 10026607962
• [Presentation] BNIP3は急性腎障害において誘導され近位尿細管細胞のAutophagyとMitophagyを調整する (2012)
  • Author(s): 緒方巧二,石原正行,久雅之,文勝徹,島村芳子,濱田佳寿,平野世紀,井上紘輔,香川 亨,寺田典生
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] たこつぼ型心筋症を合併した強皮症腎クリーゼの一例 (2012)
  • Author(s): 緒方巧二,江間宏樹,島村芳子,井上紘輔,高田浩史,次田誠,香川 亨,寺田典生
  • Organizer: 第42回日本腎臓学会西部学術大会
  • Place of Presentation: 宜野湾
• [Presentation] Small Heat Shock Protein beta-1 Is Up-Regulated and Regulates Autophagy and Apoptosis of Renal Tublar Cells in the Acute Kidney Injury In Vitro and In Vivo. (2012)
  • Author(s): Inoue K,Ogata K
  • Organizer: アメリカ腎臓学会
  • Place of Presentation: アメリカ サンディエゴコンベンションセンター
• [Presentation] ActivatedProrenin and (Pro)renin Receptor AreUp-Regukated in Glomeruli of DiabeticNephropathy and IgA Nephropathy UsingRenal Biopsy Specimen (2011)
  • Author(s): Ogata K, Shimamura Y, Inoue K, KagawaT, Nishiyama A, Terada Y
  • Organizer: ASN(AmericanSociety of Nephrology) Kidney week
  • Place of Presentation: PhiladelphiaUSA.
• [Presentation] HNF-1β,SOCS3,STAT3の情報伝達系は急性腎障害での尿細管再生と形成に重要な役割を果たす (2011)
  • Author(s): 緒方巧二,濱田佳寿,江間宏樹,島村芳子,井上紘輔,谷口義典,香川 亨,寺田典生
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Activated Prorenin and (Pro)renin Receptor Are Up-Regulated in Glomeruli of Diabetic Nephropathy and IgA Nephropathy Using Renal Biopsy Specimen (2011)
  • Author(s): Ogata K, Shimamura Y, Inoue K, Kagawa T, Nishiyama A, Terada Y
  • Organizer: ASN(American Society of Nephrology )Kidney week 2011
  • Place of Presentation: ペンシドニアコンベンションセンター(米国)
• [Presentation] Up-Regulated HNF-1β during Experimental Acute Kidney Injury Plays a Crucial Role in Renal Tubular Regeneration. (2010)
  • Author(s): Ogata K, Terada Y., et al.
  • Organizer: American Society of Nephrology 43nd Annual Meeting and Scientific Exposition
  • Place of Presentation: Colorado Convention Center, Denver, USA.
  • Year and Date: 2010-11-19
• [Presentation] Up-Regulated HNF-1 β duringExperimental Acute Kidney Injury Plays a Crucial Role in Renal Tubular Regeneration. (2010)
  • Author(s): Ogata K, Ueda S, Shimamura Y, Inoue K,Taniguchi Y, Ishihara M, Kagawa T,Horino T, Takao T, Terada Y
  • Organizer: American Society of Nephrology 43th Annual Meeting and Scientific Exposition.
  • Place of Presentation: Denver in USA
• [Presentation] 急性腎障害での尿細管再生・増殖におけるHNF-1β,SOCS3,STAT3系の役割 (2010)
  • Author(s): 緒方巧二,島村芳子,井上紘輔,谷口義典,香川 亨,堀野太郎,高尾俊弘,森田達仁,寺田典生
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
• [Presentation] MPO-ANCA関連血管炎による肥厚生硬膜炎の一例 (2010)
  • Author(s): 緒方巧二,堀野太郎,田口崇文,島村芳子,谷口義典,井上紘輔,香川 亨,森田達仁,寺田典生
  • Organizer: 第54回日本リウマチ学会総会学術集会
  • Place of Presentation: 神戸
• [Presentation] HNF-1β,SOCS3,and STAT3 are regulatedduring experimental acute kidneyinjury in vivo and affect renaltubular proliferation in vitro (2010)
  • Author(s): Ogata K, Shimamura Y, Inoue K,Taniguchi Y, Kagawa T, Horino T, TakaoT, Morita T, Terada Y
  • Organizer: ISNNEXUS Symposium.
  • Place of Presentation: Kyoto
• [Book] AKIの病態,管理と予後.医薬ジャーナル11月号48(11) (2012)
  • Author(s): 緒方巧二,松本竜季,濱田佳寿,谷口義典,寺田典生
• [Book] 管内増殖性糸球体腎炎.別冊 腎臓症候群 (2012)
  • Author(s): 緒方巧二,島村芳子,井上紘輔,香川 亨,寺田典生
  • Publisher: 日本臨牀社
• [Book] AKIの予後と再生療法.AKI急性腎障害のすべて 基礎から臨床までの最新知見,PartI臨床総論 (2012)
  • Author(s): 緒方巧二,寺田典生
  • Publisher: 南江堂
• [Book] AKIのすべて 基礎から臨床までの最新知見 (2012)
  • Author(s): 緒方巧二
  • Publisher: 南江堂
• [Book] 巣状糸球体硬化症 -病因から治療まで-.臨牀と研究 第88巻第4号 (2011)
  • Author(s): 緒方巧二,濱田佳寿,上田訓子,島村芳子,井上紘輔,谷口義典,香川 亨,寺田典生
• [Book] 炭酸脱水酵素阻害薬、浸透圧利尿薬、バソプレッシン拮抗薬(臨床医が知っておくべきこと、将来性を含めて) (2011)
  • Author(s): 緒方巧二,島村芳子,井上紘輔,香川 亨,寺田典生
  • Publisher: Modern Physician
• [Book] 多発性骨髄腫と腎障害.綜合臨牀vol.60(6) (2011)
  • Author(s): 緒方巧二,上田訓子,島村芳子,井上紘輔,香川 亨,寺田典生