Analysis of the effect of human living specimen on amyloid β-protein oligomerization

• Project/Area Number: 22790815
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Kanazawa University
• Principal Investigator: ONO Kenjiro 金沢大学, 大学病院, 講師 (70377381)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳神経疾患 / 認知症 / アミロイドβ蛋白 / オリゴマー

Research Abstract

Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ40 and Aβ42 usingphoto-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ40 and Aβ42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization.

Research Products

• [Journal Article] Nicotinamide riboside restores cognition through an up-regulation of PGC-1α regulated BACE1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. (2013)
  • Author(s): Gong B
  • Journal Title: Neurobiol Aging Volume: 34 Issue: 6 Pages: 1581-1588
  • DOI: 10.1016/j.neurobiolaging.2012.12.005
  • Peer Reviewed
• [Journal Article] Nicotinamide riboside restores cognition through an up-regulation of PGC-1α regulated BACE1 degradation and mitochondrial gene expression in Alzheimer's mouse models (2012)
  • Author(s): Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Pasinetti GM
  • Journal Title: Neurobiol. Aging Volume: (in press)
  • URL: http://dx.doi.org/10.1016/j.neurobiolaging.2012.12.005
  • Peer Reviewed
• [Journal Article] Cross-seeding effects of amyloid β-protein and α-synuclein (2012)
  • Author(s): Ono K,*Takahashi R,*Ikeda T, Yamada M
  • Journal Title: J Neurochem Volume: 122 Issue: 5 Pages: 883-90
  • DOI: 10.1111/j.1471-4159.2012.07847.x
  • NAID: 120005285928
  • Peer Reviewed
• [Journal Article] Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding (2012)
  • Author(s): Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki JI, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
  • Journal Title: J Biol Cbem Volume: (印刷中) Issue: 18 Pages: 14631-14643
  • DOI: 10.1074/jbc.m111.325456
  • Peer Reviewed
• [Journal Article] Effect of melatonin on α-synuclein self-assembly and cytotoxicity (2012)
  • Author(s): Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M
  • Journal Title: Neurobiol. Aging Volume: 33 Issue: 9 Pages: 2172-2185
  • DOI: 10.1016/j.neurobiolaging.2011.10.015
  • Peer Reviewed
• [Journal Article] Vitamin A and Alzheimer's disease (2012)
  • Author(s): Ono K, Yamada M
  • Journal Title: Geriatr. Gerontol. Int Volume: 12 Issue: 2 Pages: 180-188
  • DOI: 10.1111/j.1447-0594.2011.00786.x
  • NAID: 10031147981
  • Peer Reviewed
• [Journal Article] Anti-amyloidogenic effects of soybean isoflavones in vitro: fluorescence spectroscopy demonstrating direct binding to Aβ monomers,oligomers and fibrilsBiochim. (2012)
  • Author(s): Hirohata M, Ono K, Takasaki JI, Takahashi R, Ikeda T, Morinaga A, Yamada M
  • Journal Title: Biophys. Acta (Molecular Basis of Disease) Volume: 1822 Issue: 8 Pages: 1316-1324
  • DOI: 10.1016/j.bbadis.2012.05.006
  • Peer Reviewed
• [Journal Article] Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy (2012)
  • Author(s): Takahashi R, Ono K, Ikeda T, Akagi A, Noto D, Nozaki I, Sakai K, Asakura H, Iwasa K, Yamada M
  • Journal Title: Amyloid Volume: 19 Issue: 3 Pages: 129-132
  • DOI: 10.3109/13506129.2012.691918
  • NAID: 120004754690
  • Peer Reviewed
• [Journal Article] Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G (2012)
  • Author(s): Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G
  • Journal Title: J. Neurosci Volume: 11 Issue: 15 Pages: 5144-5150
  • DOI: 10.1523/jneurosci.6437-11.2012
  • Peer Reviewed
• [Journal Article] Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease (2012)
  • Author(s): Shima K, Samuraki M, Chen WP, Yanase D, Noguchi-Shinohara M, Takeda N, Ono K, Yoshita M, Miyazaki Y, Matsuda H, Yamada M, Matsunari I
  • Journal Title: Neurobiol. Aging Volume: 33 Issue: 9 Pages: 2006-2017
  • DOI: 10.1016/j.neurobiolaging.2011.07.009
  • NAID: 10031007048
  • Peer Reviewed
• [Journal Article] Parkinson's disease showing progressive conduction aphasia (2012)
  • Author(s): Sakai K, Ono K, Harada H, Shima K, Notoya M, Yamada M
  • Journal Title: Neurol. Sci Volume: 33 Issue: 2 Pages: 399-402
  • DOI: 10.1007/s10072-011-0751-9
  • NAID: 120003386992
  • Peer Reviewed
• [Journal Article] Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment (2012)
  • Author(s): Wang. J, Ferruzzi. MG, Ho. L,Blount. J, Janle. EM, Gong. B,Pan. Y, Gowda. N, Raftery. D,Arrieta-Cruz. I, Sharma. V, Cooper. B, Lobo. J, Simon. J, Zhang. C, Cheng. A, Qian. X, Ono. K, Teplow. DB, Pavlides. C, Dixon. R, Pasinetti. G
  • Journal Title: J Neurosci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Vitamin A and Alzheimer's disease (2012)
  • Author(s): Ono. K. Yamada. M
  • Journal Title: Geriatr Gerontol Int Volume: (in press)
  • NAID: 10031147981
  • Peer Reviewed
• [Journal Article] Effect of Age and Sex mismatched Normal Database on Diagnostic Performance of 18F-FDG PET for Alzheimer's Disease: The Ishikawa Brain Imaging Study (2011)
  • Author(s): Chen WP, Samuraki M, Shima K, Yanase D, Nozomi, Takeda N, Miyazaki Y, Ono K, Yoshita M, Nishimura S, Yamada M, Matsunari I
  • Journal Title: Nucl. Med. Commun Volume: 32 Issue: 12 Pages: 1128-1133
  • DOI: 10.1097/mnm.0b013e32834b43c2
  • Peer Reviewed
• [Journal Article] Vitamin A has antioligomerization effects on amyloid β-protein in vitro (2011)
  • Author(s): Takasaki J-I, Ono K, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
  • Journal Title: J Alzheimers Dis Volume: 27 Issue: 2 Pages: 271-280
  • DOI: 10.3233/jad-2011-110455
  • Peer Reviewed
• [Journal Article] Carvedilol as a potential novel agent for the treatment of Alzheimer's disease (2011)
  • Author(s): Wang J, Ono K, Dickstein D, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Ferruzzi MG, Pavlides C, Ho L, Hof P, Teplow DB, Pasinetti GM
  • Journal Title: Neurobiol. Aging Volume: 32 Issue: 12 Pages: 2321.e1-2321.e12
  • DOI: 10.1016/j.neurobiolaging.2010.05.004
  • Peer Reviewed
• [Journal Article] (2011) Familial Parkinson disease mutations influence α-synuclein assembly (2011)
  • Author(s): Ono K, Takasaki J, Ikeda T, Yamada M
  • Journal Title: Neurobiol. Dis Volume: 43 Issue: 3 Pages: 715-724
  • DOI: 10.1016/j.nbd.2011.05.025
  • Peer Reviewed
• [Journal Article] Effects of sex hormones on Alzheimer Disease-associated β-amyloid oligomer formation in vitro (2011)
  • Author(s): Morinaga A, Ono K, Takasaki J, Ikeda T, Hirohata M, Yamada M
  • Journal Title: Exp. Neurol Volume: 228 Issue: 2 Pages: 298-302
  • DOI: 10.1016/j.expneurol.2011.01.011
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation (2011)
  • Author(s): Hirohata M, Ono K, Morinaga A, Ikeda T, Yamada M
  • Journal Title: Neurosci. Lett Volume: 491 Issue: 1 Pages: 48-52
  • DOI: 10.1016/j.neulet.2011.01.005
  • Peer Reviewed
• [Journal Article] Low-n oligomers as therapeutic targets of Alzheimer's disease (2011)
  • Author(s): Ono K, Yamada M
  • Journal Title: J. Neurochem Volume: 117 Issue: 1 Pages: 19-28
  • DOI: 10.1111/j.1471-4159.2011.07187.x
  • Peer Reviewed
• [Journal Article] Cervical flexion myelopathy in a patient showing apparent long tract signs: a severe form of Hirayama disease (2011)
  • Author(s): Sakai K, Ono K, Okamoto Y, Murakami H and Yamada M
  • Journal Title: Joint Bone Spine Volume: 78 Issue: 3 Pages: 316-318
  • DOI: 10.1016/j.jbspin.2010.12.008
  • NAID: 120002772028
  • Peer Reviewed
• [Journal Article] Imaging Findings of Familial Dementia with a Tau R406W Mutation (2011)
  • Author(s): Komatsu J, Ono K, Yanase D, Samuraki M, Shima K, Kuwano R, Matsunari I, Yamada M
  • Journal Title: Acta Neurol. Berg Volume: 111 Pages: 374-375
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22368988
  • Peer Reviewed
• [Journal Article] Fisher syndrome associated with immune thrombocytopenic purpura (2011)
  • Author(s): Furukawa Y, Iwasa K, Ono K and Yamada M
  • Journal Title: Intern. Med Volume: 50 Pages: 631-633
  • NAID: 130000649898
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21422692
  • Peer Reviewed
• [Journal Article] Findings of Familial Dementia with a Tau R406W Mutation (2011)
  • Author(s): Komatsu. J, Ono. K,Yanase. D, Samuraki. M, Shima. K, Kuwano. R, Matsunari. I, Yamada. M
  • Journal Title: Acta Neurol Berg Volume: 111 Pages: 374-375
  • Peer Reviewed
• [Journal Article] Cervical flexion myelopathy in a patient showing apparent long tract signs : a severe form of Hirayama disease (2011)
  • Author(s): Sakai. K, Ono. K,Okamoto. Y, Murakami. H, Yamada. M
  • Journal Title: Joint Bone Spine Volume: 78 Pages: 316-318
  • NAID: 120002772028
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation (2011)
  • Author(s): Hirohata. M, Ono. K, Morinaga. A, Ikeda. T, Yamada. M
  • Journal Title: Neurosci Lett Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A comparison of the diagnosticsensitivity of MRI, CBF-SPECT, FDG-PET, and cerebrospinal fluid biomarkers for detecting Alzheimer's disease in a memory clinic (2010)
  • Author(s): Morinaga A, Ono K, Ikeda T, Ikeda Y, Shima K, Shinohara M,Samuraki M,Yanase D, Yoshita M, Mastunari I, Yamada M
  • Journal Title: Dement. Geriatr. Cogn. Disord Volume: 30 Issue: 4 Pages: 285-292
  • DOI: 10.1159/000320265
  • Peer Reviewed
• [Journal Article] Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease (2010)
  • Author(s): Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM
  • Journal Title: J. Alzheimers. Dis Volume: 22 Issue: 2 Pages: 653-661
  • DOI: 10.3233/jad-2010-101074
  • Peer Reviewed
• [Journal Article] Ono K, Condron MM, Teplow DB (2010)
  • Author(s): Ono K, Condron MM, Teplow DB
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 30 Pages: 23186-23197
  • DOI: 10.1074/jbc.m109.086496
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid of Alzheimer patients promotes amyloid β-Protein oligomerization (2010)
  • Author(s): Ikeda T, Ono K, Elashoff D, Margaret C, Noguchi-Shinohara M, Yoshita M, Teplow DB, Yamada M
  • Journal Title: J. Alzheimers. Dis Volume: 21 Issue: 1 Pages: 81-86
  • DOI: 10.3233/jad-2010-100075
  • Peer Reviewed
• [Journal Article] Sakai K, Ono K, Ohta K, Yamada M (2010)
  • Author(s): Sakai K, Ono K, Ohta K, Yamada M
  • Journal Title: Intern. Med Volume: 49 Pages: 1261-1262
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20558962
  • Peer Reviewed
• [Journal Article] Curcumin and Alzheimer's disease (2010)
  • Author(s): Hamaguchi T, Ono K, Yamada M.
  • Journal Title: CNS Neurosci. Ther Volume: 16 Issue: 5 Pages: 285-297
  • DOI: 10.1111/j.1755-5949.2010.00147.x
  • Peer Reviewed
• [Journal Article] A comparison of the diagnostic sensitivity of MRI, CBF-SPECT, FDG-PET, and cerebrospinal fluid biomarkers for detecting Alzheimer's disease in a memory clinic (2010)
  • Author(s): Morinaga. A, Ono. K, Ikeda. T, Ikeda. Y, Shima. K, Shinohara. M, Samuraki. M, Yanase. D, Yoshita. M, Mastunari. I, Yamada. M
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 285-292
  • Peer Reviewed
• [Journal Article] Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease (2010)
  • Author(s): Wang. J, Santa-Maria. I, Ho. L, Ksiezak-Reding. H, Ono. K, Teplow. DB, Pasinetti. GM
  • Journal Title: J Alzheimers Dis Volume: 22 Pages: 653-661
  • Peer Reviewed
• [Journal Article] Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity (2010)
  • Author(s): Ono. K, Condron. MM, Teplow. DB
  • Journal Title: J Biol Chem Volume: 285 Pages: 23186-23197
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid of Alzheimer patients promotes amyloid β-Protein oligomerization (2010)
  • Author(s): Ikeda. T, Ono. K, Elashoff. D, Condron. MM, Noguchi-Shinohara. M, Yoshita. M, Teplow. DB, Yamada. M
  • Journal Title: J Alzheimcrs Dis Volume: 21 Pages: 81-86
  • Peer Reviewed
• [Journal Article] Curcumin and Alzheimer's disease (2010)
  • Author(s): Hamaguchi. T, Ono. K, Yamada. M
  • Journal Title: CNS Neurosci Ther Volume: 16 Pages: 285-297
  • Peer Reviewed
• [Presentation] Vitamin A, Phenolic Compounds, and Alzheimer's Disease (2013)
  • Author(s): Ono K
  • Organizer: Conference on Health Aging in Asia
  • Place of Presentation: Grand Copthorne Waterfront (Singapore)
  • Invited
• [Presentation] Low order-oligomers as therapeutic targets of Alzeheimer's disease (2012)
  • Author(s): Ono K
  • Organizer: Neuroscience Seminar in University of British Columbia
  • Place of Presentation: University of British Columbia (Canada)
  • Year and Date: 2012-07-17
• [Presentation] フェノール化合物は特異的結合によってAβオリゴマー形成及びシナプス毒性を抑制する (2012)
  • Author(s): 小野賢二郎,Lei Li,高村雄策,吉池裕二,池田篤平,西条寿夫,高島明彦, David B Teplow, Michael G Zagorski,山田正仁
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場(茨城県)
• [Presentation] イソフラボンのβアミロイド蛋白モノマー・オリゴマー・線維への作用の検討 (2012)
  • Author(s): 廣畑美枝,小野賢二郎,高崎純一,高橋良一,池田篤平,森永章義,山田正仁
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場(茨城県)
• [Presentation] Vitamin A inhibits Aβ oligomerization in vitro (2012)
  • Author(s): Ono K, Takasaki J, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
  • Organizer: 第35回日本神経科学大会 Neuroscience 2012
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Vitamin A has anti-oligomerization effects on amyloid-β in vitro (2012)
  • Author(s): Ono K, Takasaki J, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
  • Organizer: Alzheimer's Association International Conference on Alzheimer's Disease 2012
  • Place of Presentation: Vancouver Convention Center (Canada)
• [Presentation] Anti-Amyloidogenic Effects of lsoflavones In Vitro: Fluorescence Spectroscopy Demonstrating Direct Interractions Between Isoflavones and Aβs (2012)
  • Author(s): Hirohata M, Ono K, Takasaki J, Yamada M
  • Organizer: Alzheimer's Association International Conference on Alzheimer's Disease 2012
  • Place of Presentation: Vancouver Convention Center (Canada)
• [Presentation] 有機化合物に焦点をあてたアルツハイマー病の予防・治療薬の開発 (2012)
  • Author(s): 小野賢二郎
  • Organizer: 第54回日本老年医学会学術集会 ノバルティス老化および老年医学研究基金受賞講演
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] ビタミンAによるAβオリゴマー形成抑制効果 (2012)
  • Author(s): 小野賢二郎,高崎純一,吉池裕二,廣畑美枝,池田篤平,森永章義,高島明彦,山田正仁
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] 家族性アミロイドポリニューロパチーの凝固・線溶異常 (2012)
  • Author(s): 高橋良一,小野賢二郎,池田篤平,赤木明生,能登大介,野崎一朗,坂井健二,朝倉英策,岩佐和夫,山田正仁
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] NSAIDsはβアミロイド蛋白オリゴマー形成抑制作用およびシーディング抑制作用を有する (2012)
  • Author(s): 廣畑美枝,小野賢二郎,高崎純一,森永章義,池田篤平,山田正仁
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] Vitamin A has anti-oligomerization effects on amyloid-β in vitro (2012)
  • Author(s): Ono K
  • Organizer: Alzheimer’s Association International Conference on Alzheimer’s Disease 2012
  • Place of Presentation: Vancouver Convention Center (Canada)
• [Presentation] ビタミンAによるAβオリゴマー形成抑制効果 (2012)
  • Author(s): 小野賢二郎
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] 有機化合物に焦点をあてたアルツハイマー病の予防・治療薬の開発 (2012)
  • Author(s): 小野賢二郎
  • Organizer: 第54回日本老年医学会学術集会 ノバルティス老化および老年医学研究基金受賞講演
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] Vitamin A inhibits Aβ oligomerization in vitro (2012)
  • Author(s): Ono K
  • Organizer: 第35回日本神経科学大会 Neuroscience 2012
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] フェノール化合物は特異的結合によってAβオリゴマー形成及びシナプス毒性を抑制する (2012)
  • Author(s): 小野賢二郎
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場（茨城県）
• [Presentation] 家族性アミロイドポリニューロパチーの凝固・線溶異常 (2012)
  • Author(s): 髙橋良一
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] NSAIDsはβアミロイド蛋白オリゴマー形成抑制作用およびシーディング抑制作用を有する (2012)
  • Author(s): 廣畑美枝
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] イソフラボンのβアミロイド蛋白モノマー・オリゴマー・線維への作用の検討 (2012)
  • Author(s): 廣畑美枝
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場（茨城県）
• [Presentation] English(H6R)及びTottori型(D7N)変異アミロイドβ蛋白の凝集および細胞毒性 (2011)
  • Author(s): 小野賢二郎、Teplow. DB、山田正仁
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-11-11
• [Presentation] アルツハイマー病βアミロイド蛋白凝集機構解明から予防・治療薬開発へ (2011)
  • Author(s): 小野賢二郎
  • Organizer: 第54回日本神経化学大会ミニランチョンセミナー
  • Place of Presentation: 瑠璃光(石川県)
  • Year and Date: 2011-09-28
• [Presentation] アルツハイマー病βアミロイド蛋白凝集機構解明から予防・治療薬開発へ (2011)
  • Author(s): 小野賢二郎
  • Organizer: 第54回日本神経化学大会ミニランチョンセミナー
  • Place of Presentation: 瑠璃光(石川県)(招待講演)
  • Year and Date: 2011-09-28
• [Presentation] English(H6R)及びTottori(D7N)型変異がアミロイドβ蛋白の凝集および細胞毒性に与える影響 (2011)
  • Author(s): 小野賢二郎、Teplow. DB、山田正仁
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Effect of melatonin on α-synuclein self-assembly and cytotoxicity (2011)
  • Author(s): Ono. K, Mochizuki. H, Ikeda. T, Nihira. T, Takasaki. J, Teplow. DB, Yamada. M
  • Organizer: Alzheimer's Association International Conference on Alzheimer's Disease 2011
  • Place of Presentation: Expo in Porte de Versailles (France)
  • Year and Date: 2011-07-18
• [Presentation] Low-n oligomers as therapeutic targets of Alzeheimer's disease (2011)
  • Author(s): Ono K
  • Organizer: Neuroscience Seminar in University of Groningen
  • Place of Presentation: University of Groningen(Netherlands)
  • Year and Date: 2011-07-15
• [Presentation] Low-n oligomers as therapeutic targets of Alzeheimer's disease (2011)
  • Author(s): Ono. K
  • Organizer: Neuroscience Seminar in University of Groningen
  • Place of Presentation: University of Groningen (Netherlands)(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] English(H6R)及びTottori(D7N)変異アミロイドβ蛋白の凝集および細胞毒性 (2011)
  • Author(s): 小野賢二郎、Teplow. DB、山田正仁
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-05-19
• [Presentation] English (H6R) 及び Tottori 型(D7N)変異アミロイドβ蛋白の凝集および細胞毒性 (2011)
  • Author(s): 小野賢二郎,David B Teplow,山田正仁
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
• [Presentation] English (H6R) 及び Tottori (D7N) 型変異がアミロイドβ蛋白の凝集および細胞毒性に与える影響 (2011)
  • Author(s): 小野賢二郎,David B Teplow,山田正仁
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] Effect of melatonin on α-synuclein self-assembly and cytotoxicity (2011)
  • Author(s): Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M
  • Organizer: Alzheimer's Association International Conference on Alzheimer's Disease 2011
  • Place of Presentation: Expo in Porte de Versailles(France)
• [Presentation] English (H6R) 及び Tottori (D7N) 変異アミロイドβ蛋白の凝集および細胞毒性 (2011)
  • Author(s): 小野賢二郎,David B Teplow,山田正仁
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] 神経変性疾患(特にアルツハイマー病、パーキンソン病)の予防・治療薬開発 (2010)
  • Author(s): 小野賢二郎
  • Organizer: 平成22年度昭和大学医学部同窓会学術講演会
  • Place of Presentation: 昭和大学医学部(東京都)
  • Year and Date: 2010-11-28
• [Presentation] 神経変性疾患(特にアルツハイマー病、パーキンソン病)の予防・治療薬開発 (2010)
  • Author(s): 小野賢二郎
  • Organizer: 平成22年度昭和大学医学部同窓会学術講演会
  • Place of Presentation: 昭和大学医学部(東京)
  • Year and Date: 2010-11-28
• [Presentation] 有機化合物に焦点を当てたアルツハイマー病の予防・治療薬の開発 (2010)
  • Author(s): 小野賢二郎
  • Organizer: 京都大学農学研究科大学院特別講義
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2010-06-21
• [Presentation] Grape derived polyphenols attenuate tau neuropathology in the tmht mouse model of Alzheimer's disease (2010)
  • Author(s): Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM
  • Organizer: Neuroscience Nanosymposium 2010
  • Place of Presentation: San Diego Convention Center (USA)
• [Presentation] Aβ凝集機構解明から予防・治療薬開発へ (2010)
  • Author(s): 小野賢二郎
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: ウインクあいち(愛知県)
• [Presentation] Structure-neurotoxicity relationships of amyloid β-protein oligomers (2010)
  • Author(s): 小野賢二郎,David B Teplow,山田正仁
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: ウインクあいち(愛知県)
• [Presentation] アミロイドβ蛋白オリゴマーの構造及び毒性相関の解析 (2010)
  • Author(s): 小野賢二郎,David B Teplow,Margaret M Condron,山田正仁
  • Organizer: 第33回日本神経科学大会 Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
• [Presentation] Structure-neurotoxicity analysis of amyloid β-protein oligomers. (2010)
  • Author(s): Ono K, Teplow DB, Condron. MM
  • Organizer: International Conference on Alzheimer's Disease 2010
  • Place of Presentation: Hawaii Convention Center (USA)
• [Presentation] 小野賢二郎,Margaret M Condron,David B Teplow,山田正仁 (2010)
  • Author(s): 小野賢二郎,Margaret M Condron,David B Teplow,山田正仁
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] Aβ凝集機構解明から予防・治療薬開発へ (2010)
  • Author(s): 小野賢二郎
  • Organizer: 第29回日本認知症学会学術集会シンポジウム5 認知症の阻止を狙った治療薬開発研究
  • Place of Presentation: ウインクあいち(名古屋)
• [Presentation] Structure-neurotoxicity analysis of amyloid β-protein oligomers (2010)
  • Author(s): Ono. K, Teplow. DB, Condron. MM
  • Organizer: International Conference on Alzheimer's Disease 2010
  • Place of Presentation: コンベンションセンター(米国・ホノルル)
• [Presentation] Grape derived polyphenols attenuate tau neuropathology in the tmht mouse model of Alzheimer's disease (2010)
  • Author(s): Wang. J, Santa-Maria. I, Ho. L, Ksiezak-Reding. H, Ono. K, Teplow. DB, Pasinetti. GM
  • Organizer: Neuroscience Nanosymposium 2010
  • Place of Presentation: コンベンションセンター(米国・サンディエゴ)
• [Presentation] アミロイドβ蛋白オリゴマーの構造-毒性相関 (2010)
  • Author(s): 小野賢二郎, Margaret M Condron, David B Teplow, 山田正仁
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] アミロイドβ蛋白オリゴマーの構造及び毒性相関の解析 (2010)
  • Author(s): 小野賢二郎, David B Teplow, Margaret M Condron, 山田正仁
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(神戸)
• [Presentation] Structure-neurotoxicity relationships of amyloid β-protein oligomers (2010)
  • Author(s): 小野賢二郎, David B Teplow, 山田正仁
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: ウインクあいち(名古屋)
• [Presentation] Low order-oligomers as therapeutic targets of Alzeheimer’s disease
  • Author(s): Ono. K
  • Organizer: Neuroscience Seminar in University of British Columbia
  • Place of Presentation: University of British Columbia (Canada)
  • Invited
• [Remarks]
  • URL: http://neurology.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学神経内科
  • URL: http://neurology.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://neurology.w3.kanazawa-u.ac.jp/