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Analysis of the effect of human living specimen on amyloid β-protein oligomerization

Research Project

Project/Area Number 22790815
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionKanazawa University

Principal Investigator

ONO Kenjiro  金沢大学, 大学病院, 講師 (70377381)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳神経疾患 / 認知症 / アミロイドβ蛋白 / オリゴマー
Research Abstract

Oligomers of the amyloid β-protein (Aβ) play an important role in Alzheimer's disease (AD). We investigated the effect of cerebrospinal fluid (CSF) from 33 patients with AD and 33 age-matched, non-demented controls on oligomerization of Aβ40 and Aβ42 usingphoto-induced cross-linking of unmodified proteins. CSF inhibited oligomerization of both Aβ40 and Aβ42. This inhibitory effect was significantly weaker in AD patients than in non-demented controls. Our results indicate that AD patients have a CSF environment favorable for Aβ oligomerization.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (87 results)

All 2013 2012 2011 2010 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results) Presentation (47 results) (of which Invited: 3 results) Remarks (3 results)

  • [Journal Article] Nicotinamide riboside restores cognition through an up-regulation of PGC-1α regulated BACE1 degradation and mitochondrial gene expression in Alzheimer’s mouse models.2013

    • Author(s)
      Gong B
    • Journal Title

      Neurobiol Aging

      Volume: 34 Issue: 6 Pages: 1581-1588

    • DOI

      10.1016/j.neurobiolaging.2012.12.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicotinamide riboside restores cognition through an up-regulation of PGC-1α regulated BACE1 degradation and mitochondrial gene expression in Alzheimer's mouse models2012

    • Author(s)
      Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Pasinetti GM
    • Journal Title

      Neurobiol. Aging

      Volume: (in press)

    • URL

      http://dx.doi.org/10.1016/j.neurobiolaging.2012.12.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-seeding effects of amyloid β-protein and α-synuclein2012

    • Author(s)
      Ono K,*Takahashi R,*Ikeda T, Yamada M
    • Journal Title

      J Neurochem

      Volume: 122 Issue: 5 Pages: 883-90

    • DOI

      10.1111/j.1471-4159.2012.07847.x

    • NAID

      120005285928

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding2012

    • Author(s)
      Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki JI, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
    • Journal Title

      J Biol Cbem

      Volume: (印刷中) Issue: 18 Pages: 14631-14643

    • DOI

      10.1074/jbc.m111.325456

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of melatonin on α-synuclein self-assembly and cytotoxicity2012

    • Author(s)
      Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M
    • Journal Title

      Neurobiol. Aging

      Volume: 33 Issue: 9 Pages: 2172-2185

    • DOI

      10.1016/j.neurobiolaging.2011.10.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin A and Alzheimer's disease2012

    • Author(s)
      Ono K, Yamada M
    • Journal Title

      Geriatr. Gerontol. Int

      Volume: 12 Issue: 2 Pages: 180-188

    • DOI

      10.1111/j.1447-0594.2011.00786.x

    • NAID

      10031147981

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-amyloidogenic effects of soybean isoflavones in vitro: fluorescence spectroscopy demonstrating direct binding to Aβ monomers,oligomers and fibrilsBiochim.2012

    • Author(s)
      Hirohata M, Ono K, Takasaki JI, Takahashi R, Ikeda T, Morinaga A, Yamada M
    • Journal Title

      Biophys. Acta (Molecular Basis of Disease)

      Volume: 1822 Issue: 8 Pages: 1316-1324

    • DOI

      10.1016/j.bbadis.2012.05.006

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy2012

    • Author(s)
      Takahashi R, Ono K, Ikeda T, Akagi A, Noto D, Nozaki I, Sakai K, Asakura H, Iwasa K, Yamada M
    • Journal Title

      Amyloid

      Volume: 19 Issue: 3 Pages: 129-132

    • DOI

      10.3109/13506129.2012.691918

    • NAID

      120004754690

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G2012

    • Author(s)
      Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda N, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon J, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon R, Pasinetti G
    • Journal Title

      J. Neurosci

      Volume: 11 Issue: 15 Pages: 5144-5150

    • DOI

      10.1523/jneurosci.6437-11.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease2012

    • Author(s)
      Shima K, Samuraki M, Chen WP, Yanase D, Noguchi-Shinohara M, Takeda N, Ono K, Yoshita M, Miyazaki Y, Matsuda H, Yamada M, Matsunari I
    • Journal Title

      Neurobiol. Aging

      Volume: 33 Issue: 9 Pages: 2006-2017

    • DOI

      10.1016/j.neurobiolaging.2011.07.009

    • NAID

      10031007048

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinson's disease showing progressive conduction aphasia2012

    • Author(s)
      Sakai K, Ono K, Harada H, Shima K, Notoya M, Yamada M
    • Journal Title

      Neurol. Sci

      Volume: 33 Issue: 2 Pages: 399-402

    • DOI

      10.1007/s10072-011-0751-9

    • NAID

      120003386992

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment2012

    • Author(s)
      Wang. J, Ferruzzi. MG, Ho. L,Blount. J, Janle. EM, Gong. B,Pan. Y, Gowda. N, Raftery. D,Arrieta-Cruz. I, Sharma. V, Cooper. B, Lobo. J, Simon. J, Zhang. C, Cheng. A, Qian. X, Ono. K, Teplow. DB, Pavlides. C, Dixon. R, Pasinetti. G
    • Journal Title

      J Neurosci

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin A and Alzheimer's disease2012

    • Author(s)
      Ono. K. Yamada. M
    • Journal Title

      Geriatr Gerontol Int

      Volume: (in press)

    • NAID

      10031147981

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Age and Sex mismatched Normal Database on Diagnostic Performance of 18F-FDG PET for Alzheimer's Disease: The Ishikawa Brain Imaging Study2011

    • Author(s)
      Chen WP, Samuraki M, Shima K, Yanase D, Nozomi, Takeda N, Miyazaki Y, Ono K, Yoshita M, Nishimura S, Yamada M, Matsunari I
    • Journal Title

      Nucl. Med. Commun

      Volume: 32 Issue: 12 Pages: 1128-1133

    • DOI

      10.1097/mnm.0b013e32834b43c2

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin A has antioligomerization effects on amyloid β-protein in vitro2011

    • Author(s)
      Takasaki J-I, Ono K, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
    • Journal Title

      J Alzheimers Dis

      Volume: 27 Issue: 2 Pages: 271-280

    • DOI

      10.3233/jad-2011-110455

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carvedilol as a potential novel agent for the treatment of Alzheimer's disease2011

    • Author(s)
      Wang J, Ono K, Dickstein D, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Ferruzzi MG, Pavlides C, Ho L, Hof P, Teplow DB, Pasinetti GM
    • Journal Title

      Neurobiol. Aging

      Volume: 32 Issue: 12 Pages: 2321.e1-2321.e12

    • DOI

      10.1016/j.neurobiolaging.2010.05.004

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (2011) Familial Parkinson disease mutations influence α-synuclein assembly2011

    • Author(s)
      Ono K, Takasaki J, Ikeda T, Yamada M
    • Journal Title

      Neurobiol. Dis

      Volume: 43 Issue: 3 Pages: 715-724

    • DOI

      10.1016/j.nbd.2011.05.025

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sex hormones on Alzheimer Disease-associated β-amyloid oligomer formation in vitro2011

    • Author(s)
      Morinaga A, Ono K, Takasaki J, Ikeda T, Hirohata M, Yamada M
    • Journal Title

      Exp. Neurol

      Volume: 228 Issue: 2 Pages: 298-302

    • DOI

      10.1016/j.expneurol.2011.01.011

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation2011

    • Author(s)
      Hirohata M, Ono K, Morinaga A, Ikeda T, Yamada M
    • Journal Title

      Neurosci. Lett

      Volume: 491 Issue: 1 Pages: 48-52

    • DOI

      10.1016/j.neulet.2011.01.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-n oligomers as therapeutic targets of Alzheimer's disease2011

    • Author(s)
      Ono K, Yamada M
    • Journal Title

      J. Neurochem

      Volume: 117 Issue: 1 Pages: 19-28

    • DOI

      10.1111/j.1471-4159.2011.07187.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cervical flexion myelopathy in a patient showing apparent long tract signs: a severe form of Hirayama disease2011

    • Author(s)
      Sakai K, Ono K, Okamoto Y, Murakami H and Yamada M
    • Journal Title

      Joint Bone Spine

      Volume: 78 Issue: 3 Pages: 316-318

    • DOI

      10.1016/j.jbspin.2010.12.008

    • NAID

      120002772028

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Findings of Familial Dementia with a Tau R406W Mutation2011

    • Author(s)
      Komatsu J, Ono K, Yanase D, Samuraki M, Shima K, Kuwano R, Matsunari I, Yamada M
    • Journal Title

      Acta Neurol. Berg

      Volume: 111 Pages: 374-375

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22368988

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fisher syndrome associated with immune thrombocytopenic purpura2011

    • Author(s)
      Furukawa Y, Iwasa K, Ono K and Yamada M
    • Journal Title

      Intern. Med

      Volume: 50 Pages: 631-633

    • NAID

      130000649898

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21422692

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Findings of Familial Dementia with a Tau R406W Mutation2011

    • Author(s)
      Komatsu. J, Ono. K,Yanase. D, Samuraki. M, Shima. K, Kuwano. R, Matsunari. I, Yamada. M
    • Journal Title

      Acta Neurol Berg

      Volume: 111 Pages: 374-375

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cervical flexion myelopathy in a patient showing apparent long tract signs : a severe form of Hirayama disease2011

    • Author(s)
      Sakai. K, Ono. K,Okamoto. Y, Murakami. H, Yamada. M
    • Journal Title

      Joint Bone Spine

      Volume: 78 Pages: 316-318

    • NAID

      120002772028

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation2011

    • Author(s)
      Hirohata. M, Ono. K, Morinaga. A, Ikeda. T, Yamada. M
    • Journal Title

      Neurosci Lett

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of the diagnosticsensitivity of MRI, CBF-SPECT, FDG-PET, and cerebrospinal fluid biomarkers for detecting Alzheimer's disease in a memory clinic2010

    • Author(s)
      Morinaga A, Ono K, Ikeda T, Ikeda Y, Shima K, Shinohara M,Samuraki M,Yanase D, Yoshita M, Mastunari I, Yamada M
    • Journal Title

      Dement. Geriatr. Cogn. Disord

      Volume: 30 Issue: 4 Pages: 285-292

    • DOI

      10.1159/000320265

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease2010

    • Author(s)
      Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM
    • Journal Title

      J. Alzheimers. Dis

      Volume: 22 Issue: 2 Pages: 653-661

    • DOI

      10.3233/jad-2010-101074

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ono K, Condron MM, Teplow DB2010

    • Author(s)
      Ono K, Condron MM, Teplow DB
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 30 Pages: 23186-23197

    • DOI

      10.1074/jbc.m109.086496

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid of Alzheimer patients promotes amyloid β-Protein oligomerization2010

    • Author(s)
      Ikeda T, Ono K, Elashoff D, Margaret C, Noguchi-Shinohara M, Yoshita M, Teplow DB, Yamada M
    • Journal Title

      J. Alzheimers. Dis

      Volume: 21 Issue: 1 Pages: 81-86

    • DOI

      10.3233/jad-2010-100075

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sakai K, Ono K, Ohta K, Yamada M2010

    • Author(s)
      Sakai K, Ono K, Ohta K, Yamada M
    • Journal Title

      Intern. Med

      Volume: 49 Pages: 1261-1262

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20558962

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin and Alzheimer's disease2010

    • Author(s)
      Hamaguchi T, Ono K, Yamada M.
    • Journal Title

      CNS Neurosci. Ther

      Volume: 16 Issue: 5 Pages: 285-297

    • DOI

      10.1111/j.1755-5949.2010.00147.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of the diagnostic sensitivity of MRI, CBF-SPECT, FDG-PET, and cerebrospinal fluid biomarkers for detecting Alzheimer's disease in a memory clinic2010

    • Author(s)
      Morinaga. A, Ono. K, Ikeda. T, Ikeda. Y, Shima. K, Shinohara. M, Samuraki. M, Yanase. D, Yoshita. M, Mastunari. I, Yamada. M
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 285-292

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease2010

    • Author(s)
      Wang. J, Santa-Maria. I, Ho. L, Ksiezak-Reding. H, Ono. K, Teplow. DB, Pasinetti. GM
    • Journal Title

      J Alzheimers Dis

      Volume: 22 Pages: 653-661

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity2010

    • Author(s)
      Ono. K, Condron. MM, Teplow. DB
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23186-23197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid of Alzheimer patients promotes amyloid β-Protein oligomerization2010

    • Author(s)
      Ikeda. T, Ono. K, Elashoff. D, Condron. MM, Noguchi-Shinohara. M, Yoshita. M, Teplow. DB, Yamada. M
    • Journal Title

      J Alzheimcrs Dis

      Volume: 21 Pages: 81-86

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin and Alzheimer's disease2010

    • Author(s)
      Hamaguchi. T, Ono. K, Yamada. M
    • Journal Title

      CNS Neurosci Ther

      Volume: 16 Pages: 285-297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Vitamin A, Phenolic Compounds, and Alzheimer's Disease2013

    • Author(s)
      Ono K
    • Organizer
      Conference on Health Aging in Asia
    • Place of Presentation
      Grand Copthorne Waterfront (Singapore)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Low order-oligomers as therapeutic targets of Alzeheimer's disease2012

    • Author(s)
      Ono K
    • Organizer
      Neuroscience Seminar in University of British Columbia
    • Place of Presentation
      University of British Columbia (Canada)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] フェノール化合物は特異的結合によってAβオリゴマー形成及びシナプス毒性を抑制する2012

    • Author(s)
      小野賢二郎,Lei Li,高村雄策,吉池裕二,池田篤平,西条寿夫,高島明彦, David B Teplow, Michael G Zagorski,山田正仁
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Final Research Report
  • [Presentation] イソフラボンのβアミロイド蛋白モノマー・オリゴマー・線維への作用の検討2012

    • Author(s)
      廣畑美枝,小野賢二郎,高崎純一,高橋良一,池田篤平,森永章義,山田正仁
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin A inhibits Aβ oligomerization in vitro2012

    • Author(s)
      Ono K, Takasaki J, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
    • Organizer
      第35回日本神経科学大会 Neuroscience 2012
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin A has anti-oligomerization effects on amyloid-β in vitro2012

    • Author(s)
      Ono K, Takasaki J, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2012
    • Place of Presentation
      Vancouver Convention Center (Canada)
    • Related Report
      2012 Final Research Report
  • [Presentation] Anti-Amyloidogenic Effects of lsoflavones In Vitro: Fluorescence Spectroscopy Demonstrating Direct Interractions Between Isoflavones and Aβs2012

    • Author(s)
      Hirohata M, Ono K, Takasaki J, Yamada M
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2012
    • Place of Presentation
      Vancouver Convention Center (Canada)
    • Related Report
      2012 Final Research Report
  • [Presentation] 有機化合物に焦点をあてたアルツハイマー病の予防・治療薬の開発2012

    • Author(s)
      小野賢二郎
    • Organizer
      第54回日本老年医学会学術集会 ノバルティス老化および老年医学研究基金受賞講演
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] ビタミンAによるAβオリゴマー形成抑制効果2012

    • Author(s)
      小野賢二郎,高崎純一,吉池裕二,廣畑美枝,池田篤平,森永章義,高島明彦,山田正仁
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの凝固・線溶異常2012

    • Author(s)
      高橋良一,小野賢二郎,池田篤平,赤木明生,能登大介,野崎一朗,坂井健二,朝倉英策,岩佐和夫,山田正仁
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] NSAIDsはβアミロイド蛋白オリゴマー形成抑制作用およびシーディング抑制作用を有する2012

    • Author(s)
      廣畑美枝,小野賢二郎,高崎純一,森永章義,池田篤平,山田正仁
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin A has anti-oligomerization effects on amyloid-β in vitro2012

    • Author(s)
      Ono K
    • Organizer
      Alzheimer’s Association International Conference on Alzheimer’s Disease 2012
    • Place of Presentation
      Vancouver Convention Center (Canada)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ビタミンAによるAβオリゴマー形成抑制効果2012

    • Author(s)
      小野賢二郎
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 有機化合物に焦点をあてたアルツハイマー病の予防・治療薬の開発2012

    • Author(s)
      小野賢二郎
    • Organizer
      第54回日本老年医学会学術集会 ノバルティス老化および老年医学研究基金受賞講演
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Vitamin A inhibits Aβ oligomerization in vitro2012

    • Author(s)
      Ono K
    • Organizer
      第35回日本神経科学大会 Neuroscience 2012
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] フェノール化合物は特異的結合によってAβオリゴマー形成及びシナプス毒性を抑制する2012

    • Author(s)
      小野賢二郎
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 家族性アミロイドポリニューロパチーの凝固・線溶異常2012

    • Author(s)
      髙橋良一
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] NSAIDsはβアミロイド蛋白オリゴマー形成抑制作用およびシーディング抑制作用を有する2012

    • Author(s)
      廣畑美枝
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] イソフラボンのβアミロイド蛋白モノマー・オリゴマー・線維への作用の検討2012

    • Author(s)
      廣畑美枝
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] English(H6R)及びTottori型(D7N)変異アミロイドβ蛋白の凝集および細胞毒性2011

    • Author(s)
      小野賢二郎、Teplow. DB、山田正仁
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] アルツハイマー病βアミロイド蛋白凝集機構解明から予防・治療薬開発へ2011

    • Author(s)
      小野賢二郎
    • Organizer
      第54回日本神経化学大会ミニランチョンセミナー
    • Place of Presentation
      瑠璃光(石川県)
    • Year and Date
      2011-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] アルツハイマー病βアミロイド蛋白凝集機構解明から予防・治療薬開発へ2011

    • Author(s)
      小野賢二郎
    • Organizer
      第54回日本神経化学大会ミニランチョンセミナー
    • Place of Presentation
      瑠璃光(石川県)(招待講演)
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] English(H6R)及びTottori(D7N)型変異がアミロイドβ蛋白の凝集および細胞毒性に与える影響2011

    • Author(s)
      小野賢二郎、Teplow. DB、山田正仁
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of melatonin on α-synuclein self-assembly and cytotoxicity2011

    • Author(s)
      Ono. K, Mochizuki. H, Ikeda. T, Nihira. T, Takasaki. J, Teplow. DB, Yamada. M
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2011
    • Place of Presentation
      Expo in Porte de Versailles (France)
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Low-n oligomers as therapeutic targets of Alzeheimer's disease2011

    • Author(s)
      Ono K
    • Organizer
      Neuroscience Seminar in University of Groningen
    • Place of Presentation
      University of Groningen(Netherlands)
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Low-n oligomers as therapeutic targets of Alzeheimer's disease2011

    • Author(s)
      Ono. K
    • Organizer
      Neuroscience Seminar in University of Groningen
    • Place of Presentation
      University of Groningen (Netherlands)(招待講演)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] English(H6R)及びTottori(D7N)変異アミロイドβ蛋白の凝集および細胞毒性2011

    • Author(s)
      小野賢二郎、Teplow. DB、山田正仁
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] English (H6R) 及び Tottori 型(D7N)変異アミロイドβ蛋白の凝集および細胞毒性2011

    • Author(s)
      小野賢二郎,David B Teplow,山田正仁
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] English (H6R) 及び Tottori (D7N) 型変異がアミロイドβ蛋白の凝集および細胞毒性に与える影響2011

    • Author(s)
      小野賢二郎,David B Teplow,山田正仁
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of melatonin on α-synuclein self-assembly and cytotoxicity2011

    • Author(s)
      Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2011
    • Place of Presentation
      Expo in Porte de Versailles(France)
    • Related Report
      2012 Final Research Report
  • [Presentation] English (H6R) 及び Tottori (D7N) 変異アミロイドβ蛋白の凝集および細胞毒性2011

    • Author(s)
      小野賢二郎,David B Teplow,山田正仁
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経変性疾患(特にアルツハイマー病、パーキンソン病)の予防・治療薬開発2010

    • Author(s)
      小野賢二郎
    • Organizer
      平成22年度昭和大学医学部同窓会学術講演会
    • Place of Presentation
      昭和大学医学部(東京都)
    • Year and Date
      2010-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経変性疾患(特にアルツハイマー病、パーキンソン病)の予防・治療薬開発2010

    • Author(s)
      小野賢二郎
    • Organizer
      平成22年度昭和大学医学部同窓会学術講演会
    • Place of Presentation
      昭和大学医学部(東京)
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機化合物に焦点を当てたアルツハイマー病の予防・治療薬の開発2010

    • Author(s)
      小野賢二郎
    • Organizer
      京都大学農学研究科大学院特別講義
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2010-06-21
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Grape derived polyphenols attenuate tau neuropathology in the tmht mouse model of Alzheimer's disease2010

    • Author(s)
      Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM
    • Organizer
      Neuroscience Nanosymposium 2010
    • Place of Presentation
      San Diego Convention Center (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Aβ凝集機構解明から予防・治療薬開発へ2010

    • Author(s)
      小野賢二郎
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Structure-neurotoxicity relationships of amyloid β-protein oligomers2010

    • Author(s)
      小野賢二郎,David B Teplow,山田正仁
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2012 Final Research Report
  • [Presentation] アミロイドβ蛋白オリゴマーの構造及び毒性相関の解析2010

    • Author(s)
      小野賢二郎,David B Teplow,Margaret M Condron,山田正仁
    • Organizer
      第33回日本神経科学大会 Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Structure-neurotoxicity analysis of amyloid β-protein oligomers.2010

    • Author(s)
      Ono K, Teplow DB, Condron. MM
    • Organizer
      International Conference on Alzheimer's Disease 2010
    • Place of Presentation
      Hawaii Convention Center (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] 小野賢二郎,Margaret M Condron,David B Teplow,山田正仁2010

    • Author(s)
      小野賢二郎,Margaret M Condron,David B Teplow,山田正仁
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] Aβ凝集機構解明から予防・治療薬開発へ2010

    • Author(s)
      小野賢二郎
    • Organizer
      第29回日本認知症学会学術集会シンポジウム5 認知症の阻止を狙った治療薬開発研究
    • Place of Presentation
      ウインクあいち(名古屋)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structure-neurotoxicity analysis of amyloid β-protein oligomers2010

    • Author(s)
      Ono. K, Teplow. DB, Condron. MM
    • Organizer
      International Conference on Alzheimer's Disease 2010
    • Place of Presentation
      コンベンションセンター(米国・ホノルル)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Grape derived polyphenols attenuate tau neuropathology in the tmht mouse model of Alzheimer's disease2010

    • Author(s)
      Wang. J, Santa-Maria. I, Ho. L, Ksiezak-Reding. H, Ono. K, Teplow. DB, Pasinetti. GM
    • Organizer
      Neuroscience Nanosymposium 2010
    • Place of Presentation
      コンベンションセンター(米国・サンディエゴ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アミロイドβ蛋白オリゴマーの構造-毒性相関2010

    • Author(s)
      小野賢二郎, Margaret M Condron, David B Teplow, 山田正仁
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] アミロイドβ蛋白オリゴマーの構造及び毒性相関の解析2010

    • Author(s)
      小野賢二郎, David B Teplow, Margaret M Condron, 山田正仁
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structure-neurotoxicity relationships of amyloid β-protein oligomers2010

    • Author(s)
      小野賢二郎, David B Teplow, 山田正仁
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Low order-oligomers as therapeutic targets of Alzeheimer’s disease

    • Author(s)
      Ono. K
    • Organizer
      Neuroscience Seminar in University of British Columbia
    • Place of Presentation
      University of British Columbia (Canada)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://neurology.w3.kanazawa-u.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 金沢大学神経内科

    • URL

      http://neurology.w3.kanazawa-u.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://neurology.w3.kanazawa-u.ac.jp/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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