| Project/Area Number |
22790827
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
ABE Takato 慶應義塾大学, 医学部, 講師(非常勤) (30365233)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳虚血 / アストロサイト / 分泌型白血球ペプチダーゼ阻害物質 / 脳梗塞 / Nrf2 / ニューロン / Pentose Phoshate Pathway |
|---|
| Research Abstract |
First, we investigated glucose metabolism in astroglia during hypoxia. Hypoxia without glucoprivation induced pentose phosphate pathway(PPP) activation in astroglia. PPP activation by hypoxia was accompanied by Nrf2 translocation to the nucleus but not by Bip expression in the ER. Next, we investigated the effects of secretory leukoprotease inhibitor(SLPI) on the cell damage during ischemic-reperfusion injury. Alamar Blue reduction increased by SLPI during oxygen glucose deprivation in neurons, while SLPI did not affect astroglial cell viability. The effects of SLPI in cerebral ischemia might be different between astrocytes and neurons.
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