Parkin dysfunction results in defective depolarization-induced exocytosis

• Project/Area Number: 22790832
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: EGUCHI Hiroto 順天堂大学, 医学部, 助教 (20380868)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: パーキン / 細胞骨格蛋白 / 放出機構 / 糖尿病 / parkin / exocytosis / septin / diabetes

Research Abstract

We reported that Parkin-deficient mice have shown impaired inuslin exocytosis and neurotransmission by altered expression of proteins that are involved in the regulation of cytoskeleton polymerization. Interaction of cytoskeleton protein and syntaxin1 was increased in parkin-deficent mice brain. Parkin-deficent mice had impaired insulin exocytosis in OGTT. Parkin may play a role in cytoskeleton polymerization and neurotransmition and insulin exocytosis. Parkin may be associated with an increased risk of diabetes onset.

Research Products

• [Journal Article] (2011)
  • Author(s): Hattori N, Eguchi H, Imaizumi M, Saiki S, Sato S, Nagamatsu S
  • Journal Title: Rinsho Shinkeigaku Volume: 51(11) Pages: 986-7
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
  • Journal Title: Neurobiol Dis Volume: 43(3) Pages: 651-62
  • Peer Reviewed
• [Journal Article] The pathomechanisms of young-onset Parkinson's disease (PD), approach to the causes of PD form the mechanisms of insulin secretion system (2011)
  • Author(s): 服部信孝
  • Journal Title: Rinsho Shinkeigaku Volume: 51 Issue: 11 Pages: 986-987
  • DOI: 10.5692/clinicalneurol.51.986
  • NAID: 130004504947
  • ISSN: 0009-918X, 1882-0654
• [Journal Article] (2010)
  • Author(s): Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N
  • Journal Title: FEBS Lett Volume: 584(6) Pages: 1073-9
  • Peer Reviewed
• [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. (2010)
  • Author(s): Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N.
  • Journal Title: FEBS Lett. Volume: 584(6) Pages: 1073-1079
  • Peer Reviewed
• [Presentation] Parkinノックアウトマウスにおける分泌機構の検討 (2011)
  • Author(s): 江口博人
  • Organizer: 第5回パーキンソン病.運動障害疾患コングレス
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-10-06
• [Presentation] Parkinノックアウトマウスにおける分泌機構の検討 (2011)
  • Author(s): 江口博人
  • Organizer: 第5回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-10-06
• [Presentation] Parkinノックアウトマウスにおける分泌機構の検討 (2011)
  • Author(s): 江口博人
  • Organizer: 第52回神経学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-05-19
• [Presentation] Parkin遺伝子異常による病態と放出機構の関係の検討 (2010)
  • Author(s): 江口博人
  • Organizer: 第4回パーキンソン病.運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオークラ
  • Year and Date: 2010-10-09
• [Presentation] Parkin遺伝子異常による病態と放出機構の関係の検討 (2010)
  • Author(s): 江口博人
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-20
• [Presentation] パーキン遺伝子の病態の放出機構への関与の検討 (2010)
  • Author(s): 江口博人
  • Organizer: 神経学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] パーキン遺伝子の病態の放出機構への関与の検討 (2010)
  • Author(s): 江口博人
  • Organizer: 第5回パーキンソン病運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオークラ