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Parkin dysfunction results in defective depolarization-induced exocytosis

Research Project

Project/Area Number 22790832
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

EGUCHI Hiroto  順天堂大学, 医学部, 助教 (20380868)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsパーキン / 細胞骨格蛋白 / 放出機構 / 糖尿病 / parkin / exocytosis / septin / diabetes
Research Abstract

We reported that Parkin-deficient mice have shown impaired inuslin exocytosis and neurotransmission by altered expression of proteins that are involved in the regulation of cytoskeleton polymerization. Interaction of cytoskeleton protein and syntaxin1 was increased in parkin-deficent mice brain. Parkin-deficent mice had impaired insulin exocytosis in OGTT. Parkin may play a role in cytoskeleton polymerization and neurotransmition and insulin exocytosis. Parkin may be associated with an increased risk of diabetes onset.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article]2011

    • Author(s)
      Hattori N, Eguchi H, Imaizumi M, Saiki S, Sato S, Nagamatsu S
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 51(11) Pages: 986-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article]2011

    • Author(s)
      Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 43(3) Pages: 651-62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pathomechanisms of young-onset Parkinson's disease (PD), approach to the causes of PD form the mechanisms of insulin secretion system2011

    • Author(s)
      服部信孝
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 51 Issue: 11 Pages: 986-987

    • DOI

      10.5692/clinicalneurol.51.986

    • NAID

      130004504947

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2011 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N
    • Journal Title

      FEBS Lett

      Volume: 584(6) Pages: 1073-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.2010

    • Author(s)
      Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N.
    • Journal Title

      FEBS Lett.

      Volume: 584(6) Pages: 1073-1079

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Parkinノックアウトマウスにおける分泌機構の検討2011

    • Author(s)
      江口博人
    • Organizer
      第5回パーキンソン病.運動障害疾患コングレス
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2011-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Parkinノックアウトマウスにおける分泌機構の検討2011

    • Author(s)
      江口博人
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Parkinノックアウトマウスにおける分泌機構の検討2011

    • Author(s)
      江口博人
    • Organizer
      第52回神経学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Parkin遺伝子異常による病態と放出機構の関係の検討2010

    • Author(s)
      江口博人
    • Organizer
      第4回パーキンソン病.運動障害疾患コングレス
    • Place of Presentation
      京都ホテルオークラ
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Parkin遺伝子異常による病態と放出機構の関係の検討2010

    • Author(s)
      江口博人
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] パーキン遺伝子の病態の放出機構への関与の検討2010

    • Author(s)
      江口博人
    • Organizer
      神経学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2010 Annual Research Report
  • [Presentation] パーキン遺伝子の病態の放出機構への関与の検討2010

    • Author(s)
      江口博人
    • Organizer
      第5回パーキンソン病運動障害疾患コングレス
    • Place of Presentation
      京都ホテルオークラ
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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