Parkin dysfunction results in defective depolarization-induced exocytosis
Project/Area Number |
22790832
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Neurology
|
Research Institution | Juntendo University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | パーキン / 細胞骨格蛋白 / 放出機構 / 糖尿病 / parkin / exocytosis / septin / diabetes |
Research Abstract |
We reported that Parkin-deficient mice have shown impaired inuslin exocytosis and neurotransmission by altered expression of proteins that are involved in the regulation of cytoskeleton polymerization. Interaction of cytoskeleton protein and syntaxin1 was increased in parkin-deficent mice brain. Parkin-deficent mice had impaired insulin exocytosis in OGTT. Parkin may play a role in cytoskeleton polymerization and neurotransmition and insulin exocytosis. Parkin may be associated with an increased risk of diabetes onset.
|
Report
(3 results)
Research Products
(12 results)
-
[Journal Article]2011
Author(s)
Hattori N, Eguchi H, Imaizumi M, Saiki S, Sato S, Nagamatsu S
-
Journal Title
Rinsho Shinkeigaku
Volume: 51(11)
Pages: 986-7
Related Report
Peer Reviewed
-
[Journal Article]2011
Author(s)
Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
-
Journal Title
Neurobiol Dis
Volume: 43(3)
Pages: 651-62
Related Report
Peer Reviewed
-
-
[Journal Article]2010
Author(s)
Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N
-
Journal Title
FEBS Lett
Volume: 584(6)
Pages: 1073-9
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-