Research Project
Grant-in-Aid for Young Scientists (B)
We reported that Parkin-deficient mice have shown impaired inuslin exocytosis and neurotransmission by altered expression of proteins that are involved in the regulation of cytoskeleton polymerization. Interaction of cytoskeleton protein and syntaxin1 was increased in parkin-deficent mice brain. Parkin-deficent mice had impaired insulin exocytosis in OGTT. Parkin may play a role in cytoskeleton polymerization and neurotransmition and insulin exocytosis. Parkin may be associated with an increased risk of diabetes onset.
All 2011 2010
All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (7 results)
Rinsho Shinkeigaku
Volume: 51(11) Pages: 986-7
Neurobiol Dis
Volume: 43(3) Pages: 651-62
Volume: 51 Issue: 11 Pages: 986-987
10.5692/clinicalneurol.51.986
130004504947
FEBS Lett
Volume: 584(6) Pages: 1073-9
FEBS Lett.
Volume: 584(6) Pages: 1073-1079