Investigation of the role of insulin signaling molecules on development of hepatocytes into hepatocytes with fatty changes
Project/Area Number |
22790847
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | エネルギー / 糖質代謝異常 / 高グルコース刺激 / インスリン抵抗性 / インスリン受容体 |
Research Abstract |
We have found that chronic hyperglycemia induced marked increase of insulin receptor expression in the liver cells. I investigated if the mechanism of this change involved in a vicious cycle of hepatic insulin resistance. First, I analyzed protein expression levels of transcription factors predicted to bind with insulin receptor promoter regions and their cofactors of the various insulin acting organs with chronic high glucose stimulation, but could not identify the protein that changed its expression levels during such stimulation. Now I am further analyzing the changes during chronically high glucose stimulation with hyperinsulinemia
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.2012
Author(s)
Kikuchi T, Zhang J, Sakoda H, Koketsu Y, Fujishiro M, Kushiyama A, Nakatsu Y, Kamata H, Inoki K, Takahashi S, Kurihara H, Hideki K, Oka Y, Asano T
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Journal Title
Obesity Research and Clinical Practice
Volume: 6
Issue: 3
Pages: 175-262
DOI
Related Report
Peer Reviewed
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[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Issue: 2
Pages: 291-298
DOI
Related Report
Peer Reviewed
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
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Journal Title
American Journal of Physiology - Endocrinology and Metabolism
Volume: 302
Issue: 3
Pages: 286-296
DOI
Related Report
Peer Reviewed
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[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 286
Issue: 23
Pages: 20812-20822
DOI
Related Report
Peer Reviewed
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[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
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Journal Title
Am J Physiol Cell Physiol
Volume: 300(5)
Issue: 5
Pages: 1047-54
DOI
Related Report
Peer Reviewed
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