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Investigation of the role of insulin signaling molecules on development of hepatocytes into hepatocytes with fatty changes

Research Project

Project/Area Number 22790847
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

FUJISHIRO Midori  東京大学, 医学部附属病院, 助教 (50420211)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsエネルギー / 糖質代謝異常 / 高グルコース刺激 / インスリン抵抗性 / インスリン受容体
Research Abstract

We have found that chronic hyperglycemia induced marked increase of insulin receptor expression in the liver cells. I investigated if the mechanism of this change involved in a vicious cycle of hepatic insulin resistance. First, I analyzed protein expression levels of transcription factors predicted to bind with insulin receptor promoter regions and their cofactors of the various insulin acting organs with chronic high glucose stimulation, but could not identify the protein that changed its expression levels during such stimulation. Now I am further analyzing the changes during chronically high glucose stimulation with hyperinsulinemia

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (1 results)

  • [Journal Article] LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.2012

    • Author(s)
      Kikuchi T, Zhang J, Sakoda H, Koketsu Y, Fujishiro M, Kushiyama A, Nakatsu Y, Kamata H, Inoki K, Takahashi S, Kurihara H, Hideki K, Oka Y, Asano T
    • Journal Title

      Obesity Research and Clinical Practice

      Volume: 6 Issue: 3 Pages: 175-262

    • DOI

      10.1016/j.orcp.2011.10.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 2 Pages: 291-298

    • DOI

      10.1161/atvbaha.111.234559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal of Physiology - Endocrinology and Metabolism

      Volume: 302 Issue: 3 Pages: 286-296

    • DOI

      10.1152/ajpendo.00324.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and athe rosclerosis development2012

    • Author(s)
      Kushiyama A, Fujishiro M, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32(2) Pages: 291-298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes2012

    • Author(s)
      Iwashita M, Fujishiro M, et al
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302(3)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 23 Pages: 20812-20822

    • DOI

      10.1074/jbc.m110.206904

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 300(5) Issue: 5 Pages: 1047-54

    • DOI

      10.1152/ajpcell.00416.2010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno H, Fujishiro M, et al
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 300(5)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LST8levelcontrolsbasalp70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8

    • Author(s)
      Kikuchi T, Fujishiro M, et al
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: (In Press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 長時間高グルコース刺激による肝細胞内インスリン受容体遺伝子発現調節機構の解明2010

    • Author(s)
      藤城緑
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山市デジタルミュージアム(岡山県)
    • Year and Date
      2010-05-28
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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