| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
It has been shown that the amount of visceral fat is related to body iron content, and body iron storage is a risk factor of the development of diabetes. We examined the effect of iron deprivation in fat tissue. Iron deprivation contributed to 1) decrease of fat weight and adipocyte size, 2) reduction of macrophage invasion in fat, 3) suppression of oxidative stress and inflammatory cytokine, 4) improvement of Akt-IRS pathway. These results suggest that iron chelation improve the development of adipocyte hypertrophy via suppression of oxidative stress, leading to the amelioration of glucose tolerance.
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