The study of feeding and metabolism regulated by nesfatin-1-oxytocin-POMC system
Project/Area Number |
22790887
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Endocrinology
|
Research Institution | Jichi Medical University |
Principal Investigator |
MAEJIMA Yuko 自治医科大学, 医学部, 助教 (40438669)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 内分泌学 / オキシトシン / 弓状核 / プロオピオメラノコルチン / ネスファチン / POMC / 摂食 / プロオピオメラノコルチン(POMC) / 代謝 / 室傍核 / 孤束核 |
Research Abstract |
The activation of proopiomelanocortin neurons in Nucleus tractus solitarius(NTS) by oxytocin has been reported. However, the effect of oxytocin on POMC neurons in arcuate nucleus(ARC) has not been examined yet. This study clarified that oxytocin is physiological anorectic peptides, and activates ARC POMC neurons, as well as NTS POMC neurons. It is also suggested that oxytocin could activated ARC POMC neurons even in the leptin resistant animal model.
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Report
(3 results)
Research Products
(23 results)