The study of feeding and metabolism regulated by nesfatin-1-oxytocin-POMC system

• Project/Area Number: 22790887
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Jichi Medical University
• Principal Investigator: MAEJIMA Yuko 自治医科大学, 医学部, 助教 (40438669)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 内分泌学 / オキシトシン / 弓状核 / プロオピオメラノコルチン / ネスファチン / POMC / 摂食 / プロオピオメラノコルチン(POMC) / 代謝 / 室傍核 / 孤束核

Research Abstract

The activation of proopiomelanocortin neurons in Nucleus tractus solitarius(NTS) by oxytocin has been reported. However, the effect of oxytocin on POMC neurons in arcuate nucleus(ARC) has not been examined yet. This study clarified that oxytocin is physiological anorectic peptides, and activates ARC POMC neurons, as well as NTS POMC neurons. It is also suggested that oxytocin could activated ARC POMC neurons even in the leptin resistant animal model.

Research Products

• [Journal Article] Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y of the hypothalamic arcuate nucleus (2011)
  • Author(s): Maejima Y., Kohno D., Iwasaki Y., Yada T.
  • Journal Title: Aging(Albany NY) Volume: 3(11) Pages: 1092-1097
• [Journal Article] Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass (2011)
  • Author(s): Maejima Y., Iwasaki Y., Yamahara Y., Kodaira M., Sedbazar U., Yada T
  • Journal Title: Aging(Albany NY) Volume: 3(12) Pages: 1169-1177
• [Journal Article] Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass (2011)
  • Author(s): Yuko Maejima
  • Journal Title: Aging (Albany NY) Volume: 3 Pages: 1169-1177
  • Peer Reviewed
• [Journal Article] Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y of the hypothalamic arcuate nucleus (2011)
  • Author(s): Yuko Maejima
  • Journal Title: Aging (Albany NY) Volume: 3 Pages: 1092-1097
  • Peer Reviewed
• [Journal Article] Stressor-responsive central nesfatin-1 activates corticotrophin-releasing hormone, noradrenalin and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis (2010)
  • Author(s): Natsu Yoshida, et al.
  • Journal Title: Aging Volume: 11 Pages: 775-784
  • Peer Reviewed
• [Presentation] オキシトシンの摂食制御経路に弓状核POMCニューロンが関与する (2011)
  • Author(s): 前島裕子
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫県・淡路島
  • Year and Date: 2011-09-23
• [Presentation] 視床下部室傍核Nesfatin-1-Oxytocinによる摂食調節と病態的意義 (2011)
  • Author(s): 前島裕子
  • Organizer: 第32回日本肥満学会シンポジウム
  • Place of Presentation: 兵庫県・淡路島
  • Year and Date: 2011-09-23
• [Presentation] オキシトシンの摂食制御経路に弓状核POMCニューロンが関与する (2011)
  • Author(s): 前島裕子
  • Organizer: 第32回日本肥満学会ポスター発表
  • Place of Presentation: 兵庫県・淡路島
  • Year and Date: 2011-09-23
• [Presentation] Nesfatin-1 in hypothalamic paraventricular nucleus regulates feeding via oxytocin-melanocortin pathway (2010)
  • Author(s): Yuko Maejima
  • Organizer: The 7th Nikko International Symposium 2010
  • Place of Presentation: Jichi Medical University
  • Year and Date: 2010-10-08
• [Presentation] ネスファチン-1はオキシトシン-メラノコルチン系を介して摂食抑制する (2010)
  • Author(s): 前島裕子
  • Organizer: 第31回日本肥満学会シンポジウム
  • Place of Presentation: 群馬県・前橋市
  • Year and Date: 2010-10-02
• [Presentation] Nesfatin-1はオキシトシン・メラノコルチン系を介して摂食抑制する (2010)
  • Author(s): 前島裕子
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 群馬県前橋市
  • Year and Date: 2010-10-01
• [Presentation] Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia via melanocortin pathway (2010)
  • Author(s): Maejima Y
  • Organizer: 46^<th> annual meeting of European Association for the Study of Diabetes
  • Place of Presentation: Stockholm/Sweden
  • Year and Date: 2010-09-24
• [Presentation] Nesfatin-1-regulated oxytocinergic signalling in the paraventricular nucleus causes anorexia via melanocortin pathway (2010)
  • Author(s): Yuko Maejima
  • Organizer: 46th Annual Meeting of the EASD
  • Place of Presentation: Sweden Stockholm
  • Year and Date: 2010-09-24
• [Presentation] Feeding Regulation by Oxytocin of Hypothalamic Paraventricular Nucleus (2010)
  • Author(s): 前島裕子
  • Organizer: 第16回アディポサイエンスシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-08-21
• [Book] Medical Science Digest : Nesfatin-1による食欲と関連機能の制御 (2011)
  • Author(s): 前島裕子
  • Publisher: 北隆館/メディカルニューロサイエンス社
• [Book] 日本薬理学会誌(Folia Pharmacol. Jpn): Nesfatin-1の摂食抑制神経経路及びストレス、循環、生殖における役割 (2011)
  • Author(s): 前島裕子
  • Publisher: 日本薬理学会
• [Book] 日本薬理学会誌(Folia Pharmacol.Jpn) : Nesfatin-1の摂食抑制神経経路及びストレス、循環、生殖における役割 (2011)
  • Author(s): 前島裕子
  • Publisher: 日本薬理学会(Folia Pharmacol.Jpn)
• [Book] Medical Science Digest Vol. 37 No.1 (2011)
  • Author(s): 前島裕子
  • Total Pages: 3
  • Publisher: ニューロサイエンス社
• [Book] 肥満研究:食欲制御における視床下部・脳幹の役割 (2010)
  • Author(s): 前島裕子
  • Publisher: 肥満学会
• [Book] アディポサイエンス:視床下部・脳幹による摂食調節機構 (2010)
  • Author(s): 前島裕子
  • Publisher: フジメディカル出版
• [Book] 肥満研究Vol.16 No.3 (2010)
  • Author(s): 前島裕子
  • Total Pages: 6
  • Publisher: 日本肥満学会
• [Patent(Industrial Property Rights)] 肥満・メタボリックシンドローム治療薬、及びその動物の治療方法 (2012)
  • Inventor(s): 矢田俊彦(代表)前島裕子岩崎有作
  • Industrial Property Rights Holder: 自治医科大学
  • Filing Date: 2012-12-12
• [Patent(Industrial Property Rights)] 肥満・メタボリックシンドローム治療薬、及びその動物の治療方法 (2011)
  • Inventor(s): 矢田俊彦(代表), 前島裕子、岩崎有作
  • Industrial Property Rights Holder: 自治医科大学
  • Industrial Property Number: 2011-271652
  • Filing Date: 2011-12-12