Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor
| Project/Area Number |
22790892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORI Kenji 独立行政法人国立循環器病研究センター, 生化学部, 室長 (00416223)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 内分泌 / 神経ペプチド / 生理活性ペプチド / 受容体 |
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| Research Abstract |
A novel bioactive peptide was identified by in silico screening. This peptide was produced from a precursor protein of known neuropeptide by differential proteolytic processing. Intracerebroventricular administration of peptide to rats induced increase in plasma concentration of specific pituitary hormone. A specific binding of radiolabeled peptide to a section of rat brain was observed. To elucidate the physiological role of a newly identified peptide, mice lacking only this peptide were generated.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Issue: 4
Pages: 872-877
DOI
Related Report
Peer Reviewed
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[Journal Article] ニューロメジンＳとその多様な機能2011
Author(s)
森健二、森美和、宮里幹也、寒川賢治
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Journal Title
Comparative Endocrinology
Volume: 37
Issue: 142
Pages: 124-133
DOI
NAID
ISSN
1882-6636, 1882-6644
Related Report
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