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Research for novel regulatory mechanisms by functional analysis of novel bioactive peptide and its receptor

Research Project

Project/Area Number 22790892
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MORI Kenji  独立行政法人国立循環器病研究センター, 生化学部, 室長 (00416223)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords内分泌 / 神経ペプチド / 生理活性ペプチド / 受容体
Research Abstract

A novel bioactive peptide was identified by in silico screening. This peptide was produced from a precursor protein of known neuropeptide by differential proteolytic processing. Intracerebroventricular administration of peptide to rats induced increase in plasma concentration of specific pituitary hormone. A specific binding of radiolabeled peptide to a section of rat brain was observed. To elucidate the physiological role of a newly identified peptide, mice lacking only this peptide were generated.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 4 Pages: 872-877

    • DOI

      10.1016/j.bbrc.2011.06.081

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ニューロメジンSとその多様な機能2011

    • Author(s)
      森健二、森美和、宮里幹也、寒川賢治
    • Journal Title

      Comparative Endocrinology

      Volume: 37 Issue: 142 Pages: 124-133

    • DOI

      10.5983/nl2008jsce.37.124

    • NAID

      130004509341

    • ISSN
      1882-6636, 1882-6644
    • Related Report
      2011 Final Research Report
  • [Journal Article] ニューロメジンUノックアウトマウス2011

    • Author(s)
      森健二、児島将康
    • Journal Title

      The Lipid

      Volume: 第22巻 Pages: 4-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] 代謝制御と日内リズムをリンクするニューロメジンUとニューロメジンS2011

    • Author(s)
      森健二、宮里幹也、児島将康、寒川賢治
    • Journal Title

      実験医学増刊"代謝・内分泌ネットワークと医薬応用"

      Volume: 第29巻 Pages: 60-66

    • Related Report
      2011 Final Research Report
  • [Journal Article] Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice2011

    • Author(s)
      Sakamoto T, Nakahara K, Maruyama K, Katayama T, Mori K, Miyazato M, Kangawa K, Murakami N
    • Journal Title

      Peptides

      Volume: 32 Issue: 5 Pages: 1020-1026

    • DOI

      10.1016/j.peptides.2011.02.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ニューロメジンUとニューロメジンS2011

    • Author(s)
      森健二、寒川賢治、児島将康
    • Journal Title

      生体の科学

      Volume: 第62巻 Pages: 51-56

    • Related Report
      2011 Final Research Report
  • [Journal Article] ニューロメジンSとその多様な機能2011

    • Author(s)
      森健二, 他
    • Journal Title

      比較内分泌

      Volume: 37 Pages: 124-133

    • NAID

      10029335405

    • Related Report
      2011 Annual Research Report
  • [Journal Article] ニューロメジンUノックアウトマウス2011

    • Author(s)
      森健二, 他
    • Journal Title

      The Lipid

      Volume: 22 Pages: 4-9

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 代謝制御と日内リズムをリンクするニューロメジンUとニューロメジンS2011

    • Author(s)
      森健二, 他
    • Journal Title

      実験医学増刊"代謝・内分泌ネットワークと医薬応用"

      Volume: 29 Pages: 60-66

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice.2011

    • Author(s)
      Sakamoto T, et al.
    • Journal Title

      Peptides

      Volume: 32 Pages: 1020-1026

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ニューロメジンUとニューロメジンS2011

    • Author(s)
      森健二, 他
    • Journal Title

      生体の科学

      Volume: 62 Pages: 51-56

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats2010

    • Author(s)
      Nakahara K, Katayama T, Maruyama K, Ida T, Mori K, Miyazato M, Kangawa K, Murakami N
    • Journal Title

      J Endocrinol

      Volume: 207 Issue: 2 Pages: 185-193

    • DOI

      10.1677/joe-10-0081

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of feeding suppression by the anorexigenic hormones neuromedin U and neuromedin S in rats.2010

    • Author(s)
      Nakahara K, et al.
    • Journal Title

      Journal of Endocrinology

      Volume: 207 Pages: 185-193

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 摂食調節におけるニューロメジンSとニューロメジンU2011

    • Author(s)
      森健二、宮里幹也、中原桂子、村上昇、寒川賢治
    • Organizer
      第16回アディポサイエンス研究会
    • Place of Presentation
      大阪(千里)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Purification of a peptide from rat brain2010

    • Author(s)
      Mori K, Miyazato M, Kangawa K
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Purification of a peptide from rat brain.2010

    • Author(s)
      Mori K, et al.
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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