| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Adiponectin is an adipose tissue-specific collagen-like factor, and was previously reported to be associated with obesity and diabetes. A genetic investigation revealed one new polymorphism which more frequently showed lower concentrations of adiponectin, but not associated with hypoadiponectinemia-related diseases. This mutant protein showed a different oligomerization state of its monomer to the wild-type as determined by SDS page. The results of composition analysis suggested the importance of post-translational modifications analysis as well as amino acid sequences to clarification of pathophysiological role of adiponectin.
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