Clarification of pathophysiological role of monomer adiponectin
| Project/Area Number |
22790893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
IWASHIMA Yoshio 独立行政法人国立循環器病研究センター, 腎臓科, 医長 (80448068)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 内分泌学 / アディポネクチン / 遺伝子解析 / タンパク質の組成解析 / プロテオーム解析 / 質量分析 |
|---|
| Research Abstract |
Adiponectin is an adipose tissue-specific collagen-like factor, and was previously reported to be associated with obesity and diabetes. A genetic investigation revealed one new polymorphism which more frequently showed lower concentrations of adiponectin, but not associated with hypoadiponectinemia-related diseases. This mutant protein showed a different oligomerization state of its monomer to the wild-type as determined by SDS page. The results of composition analysis suggested the importance of post-translational modifications analysis as well as amino acid sequences to clarification of pathophysiological role of adiponectin.
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Report
(3 results)
Research Products
(47 results)
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[Journal Article] VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha.2010
Author(s)
Jesmin S, Mowa C, Sultana S, Shimojo N, Togashi H, Iwashima Y, Kato N, Sato A, Sakuma I, Hiroe M, Hattori Y, Yamaguchi N, Kobayashi H.
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Journal Title
European Journal of Pharmacology.
Volume: 641
Pages: 168-78
Related Report
Peer Reviewed
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