Identification of molecular target for malignant lymphoma treatment through understanding of clinicopathological genes

• Project/Area Number: 22790909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: MIYAZAKI Kana 三重大学, 大学院・医学系研究科, 助教 (60571627)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 悪性リンパ腫 / 網羅的遺伝子解析 / びまん性大細胞型B細胞リンパ腫 / 中枢神経系 / CD5 / マイクロアレイ

Research Abstract

CD5+ DLBCL shows a poor prognosis and high incidence of central nervous system relapse. By gene expression profiling, we confirmed that most of CD5+ DLBCLs are classified as activated B cell-like DLBCL. A classifier based on gene expression at supervised analysis also correctly identified CD5 expression. The top classifier gene supervised by CD5 expression was SH3BP5. A lot of neurological component-and function-related genes were contained in the CD5 DLBCL signature genes. Immunohistochemical analysis confirmed that SH3BP5 expression was detected on the tumor cell.

Research Products

• [Journal Article] CD5-positive diffuse large B-cell lymphoma : a retrospective study in 337 patients treated by chemotherapy with or without rituximab (2011)
  • Author(s): Miyazaki K, Yamaguchi M, Suzuki R, Kobayashi Y, Maeshima AM, Niitsu N, Ennishi D, Tamaru JI, Ishizawa K, Kashimura M, Kagami Y, Sunami K, Yamane H, Nishikori M, Kosugi H, Yujiri T, Hyo R, Katayama N, Kinoshita T, Nakamura S
  • Journal Title: Ann Oncol Volume: 22 Pages: 1601-1607
  • Peer Reviewed
• [Journal Article] CD5陽性びまん性大細胞型B細胞リンパ腫はRituximab導入により予後が改善されたか? (2011)
  • Author(s): 宮崎香奈
  • Journal Title: 血液内科 Volume: 63 Pages: 34-39
• [Journal Article] CD5-positive diffuse large B-cell lymphoma : a retrospective study in 337 patients treated by chemotherapy with or without rituximab (2011)
  • Author(s): Miyazaki K, et al
  • Journal Title: Ann Oncol Volume: 22 Issue: 7 Pages: 1601-1607
  • DOI: 10.1093/annonc/mdq627
  • Peer Reviewed
• [Journal Article] CD5-positive diffuse large B-cell lymphoma : aretrospective study in 337 patients treated by chemotherapy with or without rituximab (2011)
  • Author(s): K.Miyazaki, M.Yamaguchi, R.Suzuki, Y.Kobayashi, A.M.Maeshima, N.Niitsu, D.Ennishi, J-i.Tamaru, K.Ishizawa, M.Kashimura, Y.Kagami, K.Sunami, H.Yamane, M.Nishikori, H.Kosugi, T.Yujiri, R.Hyo, N.Katayama, T.Kinoshita, S.Nakamura
  • Journal Title: Annals of Oncology Volume: (in press)
  • Peer Reviewed
• [Journal Article] トランスクリプトームを用いた悪性リンパ腫の新たなバイオマーカーの探索 (2010)
  • Author(s): 宮崎香奈
  • Journal Title: 血液フロンティア Volume: 20 Pages: 1009-1015
• [Presentation] DLBCLにおける遺伝子発現プロファイリング-CD5発現による比較 (2011)
  • Author(s): 宮崎香奈、山口素子、小林恭子、横江香里、今井裕、小林透、珠玖洋、片山直之
  • Organizer: 第73回日本血液学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] CD5陽性びまん性大細胞型B細胞リンパ腫細胞で新たに確認された特徴的抗原発現 (2011)
  • Author(s): 横江香里、山口素子、宮崎香奈、小林恭子、片山直之
  • Organizer: 第73回日本血液学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] Clinical and molecular features of CD5+ DLBCL (2011)
  • Author(s): 宮崎香奈、山口素子
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Clinical and molecular features of CD5+DLBCL (2011)
  • Author(s): 宮崎香奈、山口素子
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-10-04
• [Presentation] DA-EPOCH-R療法および大量MTX療法で治療を行ったCD5陽性びまん性大細胞型B細胞リンパ腫 (2011)
  • Author(s): 宮崎香奈、山口素子、南博仁、小林恭子、片山直之
  • Organizer: 第51回日本リンパ網内系学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-07-02
• [Presentation] NK/T細胞腫瘍治療における最近の進歩 (2011)
  • Author(s): 宮崎香奈、山口素子
  • Organizer: 第51回日本リンパ網内系学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-07-01
• [Presentation] NK/T細胞腫瘍治療における最近の進歩 (2011)
  • Author(s): 宮崎香奈、山口素子
  • Organizer: 第51回日本リンパ網内系学会総会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-07-01
• [Presentation] Cytogenetic features of CD5-positive diffuse large B-cell lymphoma : updated results from a multicenter, retrospective study with 77 patients (2011)
  • Author(s): K Miyazaki, M Yamaguchi, J Tamaru, N Niitsu, T Yujiri, K Sunami, N Nakamura, T Kinoshita, M Kato, R Suzuki, S Nakamura, N Katayama, I Miura
  • Organizer: 11th International Conference on Malignant Lymphoma
  • Place of Presentation: Lugano, Switzerland
  • Year and Date: 2011-06-04
• [Presentation] Gene Expression Profiling of Diffuse Large B-Cell Lymphomas Supervised by CD5 Expression. (2010)
  • Author(s): Kana Miyazaki, Motoko Yamaguchi, Hiroshi Imai, Satoshi Tamaru, Tohru Kobayashi, Hiroshi Shiku, Naoyuki Katayama
  • Organizer: The 52nd annual meeting of American Society of Hematology
  • Place of Presentation: Orlando, USA
  • Year and Date: 2010-12-06
• [Presentation] Naoyuki Katayama Gene Expression Profiling of Diffuse Large B-Cell Lymphomas Supervised by CD5 Expression (2010)
  • Author(s): Kana Miyazaki, Motoko Yamaguchi, Hiroshi Imai, Satoshi Tamaru, Tohru Kobayashi, Hiroshi Shiku
  • Organizer: 52th Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2010-12-05
• [Presentation] A retrospective study of 31 patients with NK/T-cell lymphoma : Mie University Hospital experience (2010)
  • Author(s): Kana Miyazaki, Motoko Yamaguchi, Noriko Ii, Yoshihito Nomoto, Atsushi Yuta, Hiroshi Imai, Masahiro Masuya, Kazunori Nakase, Naoyuki Katayama
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] CD5陽性びまん性大細胞型B細胞リンパ腫の新規治療開発に向けた免疫組織化学による各種抗原発現の検討 (2010)
  • Author(s): 江間菜々恵、山口素子、宮崎香奈、片山直之
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Aretrospective study of 31 patients with NK/T-cell lymphoma : Mie University Hospital experience (2010)
  • Author(s): Kana Miyazaki, Motoko Yamaguchi, Noriko Ii, Yoshihito Nomoto, Atsushi Yuta, Hiroshi Imai, Masahiro Masuya, Kazunori Nakase, Naoyuki Katayama
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-25
• [Presentation] 三重大学における節外性NK/T細胞リンパ腫、鼻型31例の治療成績 (2010)
  • Author(s): 宮崎香奈、山口素子、伊井憲子、野本由人、湯田厚司、今井裕、中瀬一則、片山直之
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2010-06-19
• [Presentation] 三重大学における節外性NK/T細胞リンパ腫、鼻型31例の治療成績 (2010)
  • Author(s): 宮崎香奈、山口素子、伊井憲子、野本由人、湯田厚司、今井裕、中瀬一則、片山直之
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-06-19
• [Book] Castleman病その診断と治療 (2010)
  • Author(s): 宮崎香奈
  • Publisher: メディカルレビュー社
• [Book] 症例検討を通して学ぶ悪性リンパ腫診療の実際-リンフォーマ井戸端会議から学んだこと-」「Castleman病その診断と治療」症例2 (2010)
  • Author(s): 宮崎香奈
  • Publisher: メディカルレビュー社